ANKİLOZAN SPONDİLİT HASTALARINDA İRRİTABL BARSAK SENDROMU SIKLIĞI

Okan Avcı; Rafet Mete; Dilek Solmaz

doi:10.37696/nkmj.678114

ANKİLOZAN SPONDİLİT HASTALARINDA İRRİTABL BARSAK SENDROMU SIKLIĞI

Öz

ÖZ SUMMARY THE PREVALENCE OF IRRITABLE BOWEL SYNDROME IN PATIENTS WITH ANKYLOSING SPONDYLITIS Objective: Irritable bowel syndrome (IBS) is a functional bowel disease, characterized by altered bowel habits and chronic abdominal pain. IBS has an increased association with inflammatory pathologies such as rheumatoid arthritis (RA), but the role of inflammation in the pathophysiology of IBS hasn’t been clarified yet. Ankylosing spondylitis (AS) is a chronic inflammatory disease of the axial skeleton. The aim of our study is to determine the frequency of IBS in AS, and to reveal its relationship with other factors, primarily with disease activity. Material and Method: 145 patients with AS in the rheumatology clinic of Namık Kemal University were included. Along with demographic, clinical and laboratory data of the patients, disease activity and biologic drug use were recorded. The diagnosis and type of IBS were examined according to ROME III criteria. Results: The prevalence of IBS in patients with AS was 31.7%. Frequency of IBS was significantly higher in higher disease activity group (BASDAI>4) and in patients treated with biological agents (p values <0.001, 0.010, respectively). IBS was significantly higher in female patients by gender and young patients (<50) by age (p: 0.012 and p: 0.01 respectively). Conclusion: IBS, when compared to the normal population, was found to be higher (%31,7) in patients with AS. The relationship between AS disease activity score and IBS suggests the effect of inflammation in pathogenesis. As a result, in patients with AS, especially with high disease activity, gastroenterological complaints should be questioned; and IBS as frequent comorbidity, shouldn’t be ignored in the follow-up. ÖZET ANKİLOZAN SPONDİLİT HASTALARINDA İRRİTABL BARSAK SENDROMU SIKLIĞI Amaç: İrritabl barsak sendromu (İBS), barsak alışkanlıklarında değişim ve kronik karın ağrısı ile karakterize bağırsağın fonksiyonel bir hastalığıdır. İBS’ nin Romatoid artrit (RA) gibi inflamatuar patolojilerle artmış birlikteliğine rağmen, patofizyolojisinde inflamasyonun rolü netleştirilebilmiş değildir. Ankilozan Spondilit (AS) başlıca aksiyel iskelet sistemini tutan, kronik inflamatuvar bir hastalıkdır. Çalışmamızın amacı AS’ de İBS sıklığını tespit etmek ve bunun başta hastalık aktivitesi olmak üzere diğer faktörlerle ilişkisini ortaya koymaktır. Materyal ve Metod: Çalışmaya Namık Kemal Üniversitesi romatoloji kliniğindeki 145 AS tanılı hasta dahil edildi. Hastaların demografik, klinik ve laboratuvar verileri ile birlikte hastalık aktivitesi ve biyolojik ilaç kullanımı kaydedildi. ROMA III kriterlerine göre İBS tanısı ve tipi incelendi. Bulgular: AS hastalarındaki İBS sıklığı %31.7 idi. İBS sıklığı hastalık aktivitesi yüksek olan (BASDAI>4) ve biyolojik ajan tedavisi alanlarda anlamlı şekilde yüksekti (p<0.001 ve p: 0.01 sırasıyla). Cinsiyetler arasında İBS kadın hastalarda, yaşa göre ise genç hastalarda (<50 yaş) anlamlı şekilde yüksekti (p: 0.012 ve p<0.01 sırasıyla). Sonuç: İBS; AS hastalarında normal popülasyona kıyasla daha yüksek (%31.7) tespit edildi. AS hastalık aktivite skoru ile İBS arasındaki ilişki patogenezde inflamasyonun etkisini düşündürdü. Sonuç olarak özellikle hastalık aktivitesi yüksek olan AS hastalarında gastroenterolojik şikayetler sorgulanmalı, sık bir komorbidite olan İBS takip sürecinde göz ardı edilmemelidir.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Okan Avcı ^*
0000-0003-3773-6620
Türkiye

Rafet Mete
0000-0001-6812-6759
Türkiye

Dilek Solmaz
0000-0002-9035-689X
Türkiye

Yayımlanma Tarihi

23 Ağustos 2020

Gönderilme Tarihi

21 Ocak 2020

Kabul Tarihi

10 Nisan 2020

Yayımlandığı Sayı

Yıl 2020 Cilt: 8 Sayı: 2

DOI

https://doi.org/10.37696/nkmj.678114

IZ

https://izlik.org/JA42DD57NW

Kaynak Göster

RIS / Bibtex

APA

Avcı, O., Mete, R., & Solmaz, D. (2020). ANKİLOZAN SPONDİLİT HASTALARINDA İRRİTABL BARSAK SENDROMU SIKLIĞI. Namık Kemal Tıp Dergisi, 8(2), 117-123. https://doi.org/10.37696/nkmj.678114

AMA

1.Avcı O, Mete R, Solmaz D. ANKİLOZAN SPONDİLİT HASTALARINDA İRRİTABL BARSAK SENDROMU SIKLIĞI. NKMJ. 2020;8(2):117-123. doi:10.37696/nkmj.678114

Chicago

Avcı, Okan, Rafet Mete, ve Dilek Solmaz. 2020. “ANKİLOZAN SPONDİLİT HASTALARINDA İRRİTABL BARSAK SENDROMU SIKLIĞI”. Namık Kemal Tıp Dergisi 8 (2): 117-23. https://doi.org/10.37696/nkmj.678114.

EndNote

Avcı O, Mete R, Solmaz D (01 Ağustos 2020) ANKİLOZAN SPONDİLİT HASTALARINDA İRRİTABL BARSAK SENDROMU SIKLIĞI. Namık Kemal Tıp Dergisi 8 2 117–123.

IEEE

[1]O. Avcı, R. Mete, ve D. Solmaz, “ANKİLOZAN SPONDİLİT HASTALARINDA İRRİTABL BARSAK SENDROMU SIKLIĞI”, NKMJ, c. 8, sy 2, ss. 117–123, Ağu. 2020, doi: 10.37696/nkmj.678114.

ISNAD

Avcı, Okan - Mete, Rafet - Solmaz, Dilek. “ANKİLOZAN SPONDİLİT HASTALARINDA İRRİTABL BARSAK SENDROMU SIKLIĞI”. Namık Kemal Tıp Dergisi 8/2 (01 Ağustos 2020): 117-123. https://doi.org/10.37696/nkmj.678114.

JAMA

1.Avcı O, Mete R, Solmaz D. ANKİLOZAN SPONDİLİT HASTALARINDA İRRİTABL BARSAK SENDROMU SIKLIĞI. NKMJ. 2020;8:117–123.

MLA

Avcı, Okan, vd. “ANKİLOZAN SPONDİLİT HASTALARINDA İRRİTABL BARSAK SENDROMU SIKLIĞI”. Namık Kemal Tıp Dergisi, c. 8, sy 2, Ağustos 2020, ss. 117-23, doi:10.37696/nkmj.678114.

Vancouver

1.Okan Avcı, Rafet Mete, Dilek Solmaz. ANKİLOZAN SPONDİLİT HASTALARINDA İRRİTABL BARSAK SENDROMU SIKLIĞI. NKMJ. 01 Ağustos 2020;8(2):117-23. doi:10.37696/nkmj.678114