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COVID -19 Pnömonisinin Atipik Toraks BT Bulguları ve Klinik Korelasyonu

Yıl 2020, , 489 - 498, 20.12.2020
https://doi.org/10.37696/nkmj.790186

Öz

Amaç: Çalışmamızın amacı COVİD-19 pnömonisinin atipik BT bulgularını, eşlik eden ek patolojileri klinik ve laboratuvar bulgularıyla birlikte değerlendirmek ve tipik BT bulguları ile karşılaştırmaktır.
Materyal ve Metot: Çalışmamıza 14’ü atipik (%20,2), 55’i tipik (%79) toraks BT bulguları olan COVID-19 tanısı almış toplam 69 hasta dahil edildi. Toraks BT görüntüleri, atipik bulguları olan hastaların klinik ve laboratuvar verileri retrospektif incelendi. Tipik ve atipik grubun lezyonları ve BT şiddet skoru karşılaştırıldı.
Bulgular: Atipik BT bulguları sentrilobüler nodül, tomurcuklanmış ağaç, plevral efüzyon, lober/segmenter konsolidasyon, bronşiektazi, pulmoner emboli ve mozaik atenüasyon olup, periferik dağılım gösteren buzlu cam opasitesi (BCO) ve/veya konsolidasyon gibi tipik lezyonlara eşlik etmekteydi. BT şiddet skoru atipik grupta belirgin yüksekti (p<0,001). BT şiddet skoru yüksek olguların CRP, prokalsitonin, nötrofil oranı artmış, lenfosit sayısı azalmıştı. Atipik grupta komorbidite daha sık görüldü (%50).
Sonuç: Atipik BT bulguları olan hasta grubunun yüksek BT şiddet skoru ve yaygın akciğer tutulumu hastalığın progresyonu ya da eşlik eden diğer hastalıklara bağlı olabilir. Tipik lezyonlara atipik lezyonların eşlik etmesi raporlamada yanlış negatifliğe neden olabilir. Radyologların COVID-19 pnömonisi ile deneyimi arttıkça bu görüntüleri tipik veya atipik olarak katagorize etmeleri gelişebilir.

Kaynakça

  • 1- Jin YH, Cai L, Cheng ZS, et al. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Mil Med Res. 2020;7(1):4. Published 2020 Feb 6. doi:10.1186/s40779-020-0233-6.
  • 2- “WHO Director-General's opening remarks at the media briefing on COVID-19”. World Health Organization (WHO) (Press release). 2020 Mar 11. Retrieved 2020 March 12. Available from: URL: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid19---27-march-2020.
  • 3- “ACR Recommendations for the use of Chest Radiography and Computed Tomography (CT) for Suspected COVID-19 Infection”. American College of Radiology. 2020 March 22. Available from: URL: https://www.acr.org/Advocacy-and-Economics/ ACR-Position-Statements/Recommendations-for-Chest-Radiography-and-CT-for-Suspected-COVID19-Infection.
  • 4- Chung M, Bernheim A, Mei X, et al. CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV). Radiology. 2020; 295(1): 202‐207. doi: 10.1148/radiol. 2020200230.
  • 5- Bernheim A, Mei X, Huang M, et al. Chest CT Findings in Coronavirus Disease-19 (COVID-19): Relationship to Duration of Infection. Radiology 2020; 295:3. doi: 10.1148/radiol. 2020200463
  • 6- Salehi S, Abedi A, Balakrishnan S, et al. Coronavirus Disease-19 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients. American Journal of Roentgenology. 2020; 1-7. Doi: 10. 2214/AJR.20.23034.
  • 7- Ng M, Lee N, Yang J, et al. Imaging profile of the COVID-19 infection: radiologic findings and literature review. Radiology Cardiothoracic Imaging 2020 February 13 (Epub ahead of print). Doi: 10. 1148/ryct. 2020200034.
  • 8- Simpson S, Kay FU, Abbara S, et al. Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of radiology , and RSNA. Radiology: Cardiothoracic Imaging. 2020; 2:2. doi.org/10.1148/ryct.2020200152.
  • 9- Kim D, Quinn J, Pinsky B, et al. Rates of co-infection between SARS-CoV-2 and other respiratory pathogens. JAMA. Published online April 15, 2020. doi:10.1001/jama.2020.6266.
  • 10- Li K, Fang Y, Li W, et al. CT image visual quantitative evaluation and clinical classification of coronavirus disease (COVID-19). Eur Radiol 30, 4407–4416 (2020). https://doi.org/10. 1007/s00330-020-06817-6.
  • 11- Li K, Wu J, Wu F, et al. The Clinical and Chest CT Features Associated With Severe and Critical COVID-19 Pneumonia. Invest Radiol. 2020;55(6):327-331. doi:10.1097/RLI.0000000000000672.
  • 12- Ai T, Yang Z, Hou H, et al. Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases [published online ahead of print, 2020 Feb 26]. Radiology. 2020;200642. doi:10.1148/radiol.2020200642.
  • 13- Lei J, Li J, Li X, et al. CT Imaging of the 2019 Novel Coronavirus (2019-nCoV) Pneumonia. Radiology. 2020; 295 (1): 18 doi: 10.1148/radiol. 2020200236.
  • 14- Xiong Y, Sun D, Liu Y, et al. Clinical and High-Resolution CT Features of the COVID-19 Infection: Comparison of the Initial and Follow-up Changes. Invest Radiol. 2020;55(6):332-339. doi:10.1097/RLI.0000000000000674.
  • 15- Pan Y, Guan H, Zhou S, et al. Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China. Eur Radiol. 2020;30(6):3306-3309. doi:10.1007/s00330-020-06731-x.
  • 17- Zhao W, Zhong Z, Xie X, Yu Q, Liu J. Relation between chest CT findings and clinical conditions of coronavirus disease (COVID-19) pneumonia: a multicenter study. AJR American Journal of Roentgenology 2020; 214(5): 1072-1077.
  • 18- Guan CS, Wei LG, Xie RM, et al. CT findings of COVID-19 in follow-up: comparison between progression and recovery [published online ahead of print, 2020 May 21]. Diagn Interv Radiol. 2020;10.5152/dir.2019.20176. doi:10.5152/dir.2019.20176.
  • 19- Leonard-Lorant I, Delabranche X, Severac F, et al. Acute Pulmonary Embolism in COVID-19 Patients on CT Angiography and Relationship to D-Dimer Levels. Radiology. 2020 Apr:201561. DOI: 10.1148/radiol.2020201561.
  • 20- Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020; 8(4): 420-422. doi: 10.1016/S2213-2600(20)30076-X.
  • 21- Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-513. doi:10.1016/S0140-6736(20)30211-7.
  • Wu J, Wu X, Zeng W, Guo D, Fang Z et al. Chest CT findings in patients with corona virus disease 2019 and its relationship with clinical features. Investigative Radiology 2020; 55(5): 257261. doi: 10.1097/RLI.0000000000000670.

Atypical Chest CT Findings and Clinical Correlation of COVID-19 Pneumonia

Yıl 2020, , 489 - 498, 20.12.2020
https://doi.org/10.37696/nkmj.790186

Öz

Abstract
Aim: The aim of our study was to evaluate the atypical CT findings and concomitant pathologies of COVID-19 pneumonia together with clinical and laboratory findings and to compare them with typical CT findings.
Materials and Methods: A total of 69 patients were diagnosed with COVID-19, 14 of which were atypical (20.2%) and 55 of which were typical (79%) chest CT findings. CT images and clinical and laboratory data of patients with atypical findings were retrospectively analyzed. Lesions of the typical and atypical group and CT severity score were compared.
Results: Atypical CT findings were centrilobular nodule, tree in bud, pleural effusion, lobar / segmental consolidation, bronchiectasis, pulmonary embolism, and mosaic attenuation, accompanied by typical lesions with ground glass opacity (GGO) with/without consolidation. CT severity score was significantly higher in the atypical group (p <0.001). CRP, procalcitonin, neutrophil rate increased and lymphocyte count decreased in patients with high CT severity score. Comorbidity was more common in the atypical group (50%).
Conclusion: High CT severity score and widespread lung involvement of the patient group with atypical CT findings may be due to disease progression or other concomitant diseases. Atypical lesions accompanying typical lesions may cause false negativity in reporting. As the experience of radiologists with COVID-19 pneumonia increases, it may improve that they categorize these images as typical or atypical.

Kaynakça

  • 1- Jin YH, Cai L, Cheng ZS, et al. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Mil Med Res. 2020;7(1):4. Published 2020 Feb 6. doi:10.1186/s40779-020-0233-6.
  • 2- “WHO Director-General's opening remarks at the media briefing on COVID-19”. World Health Organization (WHO) (Press release). 2020 Mar 11. Retrieved 2020 March 12. Available from: URL: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid19---27-march-2020.
  • 3- “ACR Recommendations for the use of Chest Radiography and Computed Tomography (CT) for Suspected COVID-19 Infection”. American College of Radiology. 2020 March 22. Available from: URL: https://www.acr.org/Advocacy-and-Economics/ ACR-Position-Statements/Recommendations-for-Chest-Radiography-and-CT-for-Suspected-COVID19-Infection.
  • 4- Chung M, Bernheim A, Mei X, et al. CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV). Radiology. 2020; 295(1): 202‐207. doi: 10.1148/radiol. 2020200230.
  • 5- Bernheim A, Mei X, Huang M, et al. Chest CT Findings in Coronavirus Disease-19 (COVID-19): Relationship to Duration of Infection. Radiology 2020; 295:3. doi: 10.1148/radiol. 2020200463
  • 6- Salehi S, Abedi A, Balakrishnan S, et al. Coronavirus Disease-19 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients. American Journal of Roentgenology. 2020; 1-7. Doi: 10. 2214/AJR.20.23034.
  • 7- Ng M, Lee N, Yang J, et al. Imaging profile of the COVID-19 infection: radiologic findings and literature review. Radiology Cardiothoracic Imaging 2020 February 13 (Epub ahead of print). Doi: 10. 1148/ryct. 2020200034.
  • 8- Simpson S, Kay FU, Abbara S, et al. Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of radiology , and RSNA. Radiology: Cardiothoracic Imaging. 2020; 2:2. doi.org/10.1148/ryct.2020200152.
  • 9- Kim D, Quinn J, Pinsky B, et al. Rates of co-infection between SARS-CoV-2 and other respiratory pathogens. JAMA. Published online April 15, 2020. doi:10.1001/jama.2020.6266.
  • 10- Li K, Fang Y, Li W, et al. CT image visual quantitative evaluation and clinical classification of coronavirus disease (COVID-19). Eur Radiol 30, 4407–4416 (2020). https://doi.org/10. 1007/s00330-020-06817-6.
  • 11- Li K, Wu J, Wu F, et al. The Clinical and Chest CT Features Associated With Severe and Critical COVID-19 Pneumonia. Invest Radiol. 2020;55(6):327-331. doi:10.1097/RLI.0000000000000672.
  • 12- Ai T, Yang Z, Hou H, et al. Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases [published online ahead of print, 2020 Feb 26]. Radiology. 2020;200642. doi:10.1148/radiol.2020200642.
  • 13- Lei J, Li J, Li X, et al. CT Imaging of the 2019 Novel Coronavirus (2019-nCoV) Pneumonia. Radiology. 2020; 295 (1): 18 doi: 10.1148/radiol. 2020200236.
  • 14- Xiong Y, Sun D, Liu Y, et al. Clinical and High-Resolution CT Features of the COVID-19 Infection: Comparison of the Initial and Follow-up Changes. Invest Radiol. 2020;55(6):332-339. doi:10.1097/RLI.0000000000000674.
  • 15- Pan Y, Guan H, Zhou S, et al. Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China. Eur Radiol. 2020;30(6):3306-3309. doi:10.1007/s00330-020-06731-x.
  • 17- Zhao W, Zhong Z, Xie X, Yu Q, Liu J. Relation between chest CT findings and clinical conditions of coronavirus disease (COVID-19) pneumonia: a multicenter study. AJR American Journal of Roentgenology 2020; 214(5): 1072-1077.
  • 18- Guan CS, Wei LG, Xie RM, et al. CT findings of COVID-19 in follow-up: comparison between progression and recovery [published online ahead of print, 2020 May 21]. Diagn Interv Radiol. 2020;10.5152/dir.2019.20176. doi:10.5152/dir.2019.20176.
  • 19- Leonard-Lorant I, Delabranche X, Severac F, et al. Acute Pulmonary Embolism in COVID-19 Patients on CT Angiography and Relationship to D-Dimer Levels. Radiology. 2020 Apr:201561. DOI: 10.1148/radiol.2020201561.
  • 20- Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020; 8(4): 420-422. doi: 10.1016/S2213-2600(20)30076-X.
  • 21- Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-513. doi:10.1016/S0140-6736(20)30211-7.
  • Wu J, Wu X, Zeng W, Guo D, Fang Z et al. Chest CT findings in patients with corona virus disease 2019 and its relationship with clinical features. Investigative Radiology 2020; 55(5): 257261. doi: 10.1097/RLI.0000000000000670.
Toplam 21 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Gülcan Gücer Şahin 0000-0002-6587-867X

Tuğba İlkem Kurtoğlu Özçağlayan 0000-0003-3849-1194

Ayhan Şahin 0000-0002-3539-2353

Ömer Özçağlayan 0000-0001-5036-4919

Hadi Sasani 0000-0001-6236-4123

Yayımlanma Tarihi 20 Aralık 2020
Yayımlandığı Sayı Yıl 2020

Kaynak Göster

APA Gücer Şahin, G., Kurtoğlu Özçağlayan, T. İ., Şahin, A., Özçağlayan, Ö., vd. (2020). Atypical Chest CT Findings and Clinical Correlation of COVID-19 Pneumonia. Namık Kemal Tıp Dergisi, 8(3), 489-498. https://doi.org/10.37696/nkmj.790186
AMA Gücer Şahin G, Kurtoğlu Özçağlayan Tİ, Şahin A, Özçağlayan Ö, Sasani H. Atypical Chest CT Findings and Clinical Correlation of COVID-19 Pneumonia. NKMJ. Aralık 2020;8(3):489-498. doi:10.37696/nkmj.790186
Chicago Gücer Şahin, Gülcan, Tuğba İlkem Kurtoğlu Özçağlayan, Ayhan Şahin, Ömer Özçağlayan, ve Hadi Sasani. “Atypical Chest CT Findings and Clinical Correlation of COVID-19 Pneumonia”. Namık Kemal Tıp Dergisi 8, sy. 3 (Aralık 2020): 489-98. https://doi.org/10.37696/nkmj.790186.
EndNote Gücer Şahin G, Kurtoğlu Özçağlayan Tİ, Şahin A, Özçağlayan Ö, Sasani H (01 Aralık 2020) Atypical Chest CT Findings and Clinical Correlation of COVID-19 Pneumonia. Namık Kemal Tıp Dergisi 8 3 489–498.
IEEE G. Gücer Şahin, T. İ. Kurtoğlu Özçağlayan, A. Şahin, Ö. Özçağlayan, ve H. Sasani, “Atypical Chest CT Findings and Clinical Correlation of COVID-19 Pneumonia”, NKMJ, c. 8, sy. 3, ss. 489–498, 2020, doi: 10.37696/nkmj.790186.
ISNAD Gücer Şahin, Gülcan vd. “Atypical Chest CT Findings and Clinical Correlation of COVID-19 Pneumonia”. Namık Kemal Tıp Dergisi 8/3 (Aralık 2020), 489-498. https://doi.org/10.37696/nkmj.790186.
JAMA Gücer Şahin G, Kurtoğlu Özçağlayan Tİ, Şahin A, Özçağlayan Ö, Sasani H. Atypical Chest CT Findings and Clinical Correlation of COVID-19 Pneumonia. NKMJ. 2020;8:489–498.
MLA Gücer Şahin, Gülcan vd. “Atypical Chest CT Findings and Clinical Correlation of COVID-19 Pneumonia”. Namık Kemal Tıp Dergisi, c. 8, sy. 3, 2020, ss. 489-98, doi:10.37696/nkmj.790186.
Vancouver Gücer Şahin G, Kurtoğlu Özçağlayan Tİ, Şahin A, Özçağlayan Ö, Sasani H. Atypical Chest CT Findings and Clinical Correlation of COVID-19 Pneumonia. NKMJ. 2020;8(3):489-98.