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The effects of topiramate applied to the nucleus accumbens region on morphine withdrawal syndrome

Yıl 2020, Cilt: 8 Sayı: 2, 240 - 248, 23.08.2020
https://doi.org/10.37696/nkmj.714162

Öz

Abstract:
Objective: Nucleus accumbens, one of the nuclei of the basal ganglia, and dopamine, the neurotransmitter play a critical role in opioid dependence and withdrawal. In opioid withdrawal, the importance of neurotransmitters such as glutamate and GABA, as well as dopamine, is known. In this study, we aimed to investigate the effects of local injections of topiramate, an antiepileptic agent affecting GABAergic and glutamatergic pathways, into the nucleus accumbens on withdrawal signs and locomotor activity during naloxone-induced withdrawal in morphine-dependent rats.
Material and Method: Twenty male Sprague-Dawley rats were divided in topiramete treatment and control groups. All animals received morphine pellets and guide cannulas were placed bilaterally in the nucleus accumbens regions by stereotaxic surgery. On the last day of the experiment, following the bilateral topiramate or saline (control group) microinjections, morphine withdrawal was triggered by naloxone.
Results: Topiramate microinjections into the nucleus accumbens region significantly suppressed the signs of naloxone-induced morphine withdrawal such as number of jumpings and weight loss. No significant difference was observed in wet dog shakes, one of the withdrawal signs, after local topiramate treatment. Although topiramate microinjections increased stereotypical activity it did not change locomotor activity behavior such as vertical and ambulatory activity, and total covered distance.
Conclusion: These findings show that local microinjection of topiramate into the nucleus accumbens is effective in preventing opioid deprivation symptoms without significant leffect on locomotor activity.

Kaynakça

  • Referans1 Mahluga Jafarova Demirkapu and Hasan Raci Yananli (February 27th 2020). Opium Alkaloids [Online First], IntechOpen, doi:10.5772/intechopen.91326. Available from: https://www.intechopen.com/online-first/opium-alkaloids. Referans2 Koob GF. Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci. 1992;13(5):177-184. Referans3 Gysling K, Wang RY. Morphine-induced activation of A10 dopamine neurons in the rat. Brain Res. 1983; 277(1):119-127. Referans4 Diana M, Pistis M, Muntoni A, Gessa G. Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats. J Pharmacol Exp Ther. 1995;272(2):781-785. Referans5 Yananli H, Gören MZ, Berkman K, Aricioğlu F. Effect of agmatine on brain L-citrulline production during morphine withdrawal in rats: A microdialysis study in nucleus accumbens. Brain Research. 2007;1132:51-58. doi:10.1016/j.brainres.2006.11.028 Referans6 Topkara B, Yananli HR, Sakallı E, Demirkapu MJ. Effects of injection of gamma-aminobutyric acid agonists into the nucleus accumbens on naloxone induced morphine withdrawal. Pharmacology. 2017;100:131-138. doi:10.1159/000477548 Referans7 Demirkapu MJ, Yananlı HR, Kaleli M, Sakalli HE, Gören MZ, Topkara B. The role of adenosine A1 receptors in the nucleus accumbens during morphine withdrawal. Clinical nad Experimental Pharmacology and Physiology 2020 Apr;47(4):553-560. doi:10.1111/1440-1681.13224 Referans8 Maryanoff BE. Sugar sulfamates for seizure control: discovery and development of topiramate, a structurally unique antiepileptic drug. Curr Top Med Chem. 2009;9(11):1049-1062. doi:10.2174/156802609789630938. Referans9 Shank RP, Gardocki JF, Streeter AJ, Maryanoff BE. An overview of the preclinical aspects of topiramate: pharmacology, pharmacokinetics, and mechanism of action. Epilepsia. 2000;41 Suppl 1:S3-9. Referans10 Wenzel RG, Schwarz K, Padiyara RS. Topiramate for migraine prevention. Pharmacotherapy. 2006 Mar;26(3):375-387. doi:10.1592/phco.26.3.375. Referans11 Verrotti A, Scaparrotta A, Agostinelli S, Di Pillo S, Chiarelli F, Grosso S. Topiramate-induced weight loss: a review. Epilepsy Res. 2011;95(3):189-199. doi:10.1016/j.eplepsyres.2011.05.014. Referans12 Arnone D. Review of the use of Topiramate for treatment of psychiatric disorders. Ann Gen Psychiatry. 2005;4(1):5. doi:10.1186/1744-859X-4-5. Referans13 Garnett WR. Clinical pharmacology of topiramate: a review. Epilepsia. 2000;41 Suppl 1:S61-65. Referans14 Chung JY, Kim MW, Kim M. Efficacy of zonisamide in migraineurs with nonresponse to topiramate. Biomed Res Int. 2014;2014:891348. doi:10.1155/2014/891348. Referans15 Walker MC, Sander JW. Topiramate: a new antiepileptic drug for refractory epilepsy. Seizure. 1996;5(3):199-203. Referans16 Zhang X, Velumian AA, Jones OT, Carlen PL. Modulation of high-voltage-activated calcium channels in dentate granule cells by topiramate. Epilepsia. 2000;41 Suppl 1:S52-60. Referans17 Mula M, Cavanna AE, Monaco F: Psychopharmacology of topiramate: from epilepsy to bipolar disorder. Neuropsychiatr Dis Treat. 2006;2(4):475-488. doi:10.2147/nedt.2006.2.4.475. Referans18 Maryanoff BE, McComsey DF, Costanzo MJ, Hochman C, Smith-Swintosky V, Shank RP. Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. J Med Chem. 2005;48(6):1941-1947. Referans19 Dodgson SJ, Shank RP, Maryanoff BE. Topiramate as an inhibitor of carbonic anhydrase isoenzymes. Epilepsia. 2000;41 Suppl 1:S35-39. doi:10.1111/j.1528-1157.2000.tb06047.x. Referans20 Nishimori I, Minakuchi T, Onishi S, Vullo D, Cecchi A, Scozzafava A, Supuran CT. Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides. Bioorg Med Chem. 2007;15(23):7229-7236. Referans21 Hargreaves GA, McGregor IS. Topiramate moderately reduces the motivation to consume alcohol and has a marked antidepressant effect in rats. Alcohol Clin Exp Res. 2007;31(11):1900-1907. Referans22 Zalewska-Kaszubska J, Bajer B, Gorska D, Andrzejczak D, Dyr W, Bieńkowski P. Effect of repeated treatment with topiramate on voluntary alcohol intake and beta-endorphin plasma level in Warsaw alcohol high-preferring rats. Psychopharmacology (Berl). 2013;225(2):275-281. doi:10.1007/s00213-012-2812-z. Referans23 Cagetti E, Baicy KJ, Olsen RW. Topiramate attenuates withdrawal signs after chronic intermittent ethanol in rats. Neuroreport. 2004;15(1):207-210. Referans24 Likhitsathian S, Uttawichai K, Booncharoen H, Wittayanookulluk A, Angkurawaranon C, Srisurapanont M. Topiramate treatment for alcoholic outpatients recently receiving residential treatment programs: a 12-week, randomized, placebo-controlled trial. Drug Alcohol Depend. 2013;133(2):440-446. doi:10.1016/j.drugalcdep.2013.06.032. Referans25 Johnson BA, Rosenthal N, Capece JA, Wiegand F, Mao L, Beyers K, McKay A, Ait-Daoud N, Anton RF, Ciraulo DA, Kranzler HR, Mann K, O'Malley SS, Swift RM. Topiramate for Alcoholism Advisory Board; Topiramate for Alcoholism Study Group. Topiramate for treating alcohol dependence: a randomized controlled trial. JAMA. 2007;298(14):1641-1651. Referans26 Baltieri DA, Daró FR, Ribeiro PL, Andrade AG. Effects of topiramate or naltrexone on tobacco use among male alcohol-dependent outpatients. Drug Alcohol Depend. 2009;105(1-2):33-41. doi: 10.1016/j.drugalcdep.2009.05.025. Referans27 Ma JZ, Johnson BA, Yu E, Weiss D, McSherry F, Saadvandi J, Iturriaga E, Ait-Daoud N, Rawson RA, Hrymoc M, Campbell J, Gorodetzky C, Haning W, Carlton B, Mawhinney J, Weis D, McCann M, Pham T, Stock C, Dickinson R, Elkashef A, Li MD. Fine-grain analysis of the treatment effect of topiramate on methamphetamine addiction with latent variable analysis. Drug Alcohol Depend. 2013;130(1-3):45-51. doi:10.1016/j.drugalcdep.2012.10.009. Referans28 Kampman KM, Pettinati H, Lynch KG, Dackis C, Sparkman T, Weigley C, O'Brien CP. A pilot trial of topiramate for the treatment of cocaine dependence. Drug Alcohol Depend. 2004;75(3):233-240. Referans29 Nuijten M, Blanken P, van den Brink W, Hendriks V. Treatment of crack-cocaine dependence with topiramate: a randomized controlled feasibility trial in The Netherlands. Drug Alcohol Depend. 2014;138:177-184. doi:10.1016/j.drugalcdep.2014.02.024. Referans30 Echeverry-Alzate V, Giné E, Bühler KM, Calleja-Conde J, Olmos P, Gorriti MA, Nadal R, Rodríguez de Fonseca F, López-Moreno JA. Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex. Br J Pharmacol. 2014;171(12):3023-3036. doi:10.1111/bph.12636. Referans31 Kampman KM, Pettinati HM, Lynch KG, Spratt K, Wierzbicki MR, O'Brien CP. A double-blind, placebo-controlled trial of topiramate for the treatment of comorbid cocaine and alcohol dependence. Drug Alcohol Depend. 2013;133(1):94-99.doi:10.1016/j.drugalcdep.2013.05.026. Referans32 Umbricht A, DeFulio A, Winstanley EL, Tompkins DA, Peirce J, Mintzer MZ, Strain EC, Bigelow GE. Topiramate for cocaine dependence during methadone maintenance treatment: a randomized controlled trial. Drug Alcohol Depend. 2014;140:92-100. doi:10.1016/j.drugalcdep.2014.03.033. Referans33 Levin FR, Mariani JJ, Pavlicova M, Choi CJ, Mahony AL, Brooks DJ, Bisaga A, Dakwar E, Carpenter KM, Naqvi N, Nunes EV, Kampman K. Extended release mixed amphetamine salts and topiramate for cocaine dependence: A randomized clinical replication trial with frequent users. Drug Alcohol Depend. 2020;206:107700. doi:10.1016/j.drugalcdep.2019.107700. Referans34 Medrano MC, Mendiguren A, Pineda J. Effect of ceftriaxone and topiramate treatments on naltrexone-precipitated morphine withdrawal and glutamate receptor desensitization in the rat locus coeruleus. Psychopharmacology (Berl). 2015;232(15):2795-2809. doi:10.1007/s00213-015-3913-2. Referans35 Hajhashemi V, Abed-Natanzi M. Effect of five common anticonvulsant drugs on naloxone-precipitated morphine withdrawal in mice. Res Pharm Sci. 2011;6(1):57-62. Referans36 Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates (fourth edition).Academic press, San Diego, California, 1998. Referans37 Bhargava I IN. Rapid induction and quantitation of morphine dependence in the rat by pellet implantation. Psychopharmacology 1977;52:55-62. Referans38 Zarrindast MR, Habibi M, Borzabadi S, Fazli-Tabaei S, Hossein Yahyavi S, Rostamin P. The effects of dopamine receptor agents on naloxone-induced jumping behaviour in morphine-dependent mice. Eur J Pharmacol. 2002;451(3):287-293. Referans39 Junqueira-Ayres DD, Asth L, Ayres AS, Lobão-Soares B, Soares-Rachetti VP, Gavioli EC. Topiramate reduces basal anxiety and relieves ethanol withdrawal-induced anxious behaviors in male rats. Exp Clin Psychopharmacol. 2017;25(2):105-113. doi:10.1037/pha0000118. Referans40 Sepúlveda J, Astorga JG, Contreras E. Riluzole decreases the abstinence syndrome and physical dependence in morphine-dependent mice. Eur J Pharmacol. 1999;379(1):59-62. Referans41 Zullino DF, Cottier AC, Besson J. Topiramate in opiate withdrawal. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Oct;26(6):1221-1223. Referans42 Gracy KN, Pickel VM Ultrastructural immunocytochemical localization of the N-methyl-D-aspartate receptor and tyrosine hydroxylase in the shell of the rat nucleus accumbens. Brain Res. 1996 Nov 01, 739(1-2):169-181. Referans43 Tarazi FI, Campbell A, Yeghiayan SK, Baldessarini RJ. Localization of ionotropic glutamate receptors in caudate-putamen and nucleus accumbenssepti of rat brain: comparison of NMDA, AMPA, and kainate receptors. Synapse. 1998; 30(2): 227-235. Referans44 Conrad KL, Tseng KY, Uejima JL, et al. Formation of accumbens GluR2- lacking AMPA receptors mediates incubation of cocaine craving. Nature. 2008;454(7200):118–121. Referans45 McCutcheon JE, Wang X, Tseng KY, Wolf ME, Marinelli M. Calciumpermeable AMPA receptors are present in nucleus accumbens synapses after prolonged withdrawal from cocaine self-administration but not experimenter-administered cocaine. J Neurosci. 2011;31(15): 5737–5743. Referans46 McLemore GL, Kest B, Inturrisi CE. The effects of LY293558, an AMPA receptor antagonist, on acute and chronic morphine dependence. Brain Res. 1997;778(1):120-126. Referans47 Ostadhadi S, Khan MI, Norouzi-Javidan A, Chamanara M, Jazaeri F, Zolfaghari S, Dehpour AR. Involvement of NMDA receptors and L-arginine/nitric oxide/cyclic guanosine monophosphate pathway in the antidepressant-like effects of topiramate in mice forced swimming test. Brain Res Bull. 2016 Apr;122:62-70. doi:10.1016/j.brainresbull.2016.03.004. Referans48 Jasinski DR, Johnson RE, Kocher TR. Clonidine in morphine withdrawal. Differential effects on signs and symptoms. Arch Gen Psychiatry. 1985;42(11):1063-1066. Referans49 Pappagallo M. Incidence, prevalence, and management of opioid bowel dysfunction. Am J Surg. 2001;182(5A Suppl):11S-18S. doi:10.1016/s0002-9610(01)00782-6. Referans50 Meissner W, Schmidt U, Hartmann M, et al. Oral naloxone reverses opioid-associated constipation. Pain 2000;84:105–109. Referans51 Fisher D, Grap MJ, Younger JB, Ameringer S, Elswick RK. Opioid withdrawal signs and symptoms in children: frequency and determinants. Heart Lung. 2013;42(6):407-13. doi:10.1016/j.hrtlng.2013.07.008. Referans52 Adams RE, Wooten GF. Dependence and withdrawal following intracerebroventricular and systemic morphine administration: functional anatomy and behavior. Brain Res. 1990;518(1-2):6-10. Referans53 Garner JP, Mason GJ. Evidence for a relationship between cage stereotypies and behavioural disinhibition in laboratory rodents. Behav Brain Res. 2002 17;136(1):83-92. doi:10.1016/s0166-4328(02)00111-0. Referans54 Pappas SS, Leventhal DK, Albin RL, Dauer WT. Mouse models of neurodevelopmental disease of the basal ganglia and associated circuits. Curr Top Dev Biol. 2014;109:97-169. doi:10.1016/B978-0-12-397920-9.00001-9. Referans55 Druhan JP, Walters CL, Aston-Jones G. Behavioral activation induced by D(2)-like receptor stimulation during opiate withdrawal. J Pharmacol Exp Ther. 2000;294(2):531-538. Referans56 Lee JM, DeLeon-Jones F, Fields JZ, Ritzmann RF. Cyclo (Leu-Gly) attenuates the striatal dopaminergic supersensitivity induced by chronic morphine. Alcohol Drug Res. 1987;7(1):1-10. Referans57 Hamlin AS, McNally GP, Westbrook RF, Osborne PB. Induction of Fos proteins in regions of the nucleus accumbens and ventrolateral striatum correlates with catalepsy and stereotypic behaviours induced by morphine. Neuropharmacology. 2009 Mar;56(4):798-807.

Nukleus akumbens bölgesine uygulanan topiramatın morfin yoksunluk sendromu üzerine etkileri

Yıl 2020, Cilt: 8 Sayı: 2, 240 - 248, 23.08.2020
https://doi.org/10.37696/nkmj.714162

Öz

Amaç: Bazal gangliyon çekirdeklerinden biri olan nukleus akumbens ve nörotransmitter olan dopamin opioid bağımlılığı ve yoksunluğunda kritik rol oynamaktadır. Opioid yoksunluğunda dopaminin yanı sıra glutamat ve GABA gibi nörotransmitterlerin de önemi bilinmektedir. Biz bu çalışmada morfin bağımlısı hayvanlarda GABAerjik ve glutamaterjik yolakları etkileyen antiepileptik ajan olan topiramatın nukleus akumbens bölgesine lokal uygulamasının naloksonla tetiklenen yoksunluk sendromunda yoksunluk bulguları ve lokomotor aktivite üzerine etkilerini araştırmayı amaçladık.
Materyal ve Metot: Yirmi adet erkek Sprague-Dawley sıçanları topiramat tedavi grubu ve kontrol grubuna ayrıldı. Hayvanların hepsine morfin peletleri uygulandı, stereotaksik cerrahi işlemle nukleus akumbens bölgelerine kılavuz kanüller bilaretal yerleştirildi. Deneyin son gününde bilateral topiramat veya serum fizyolojik (kontrol grubu) mikroenjeksiyonlarını takiben nalokson uygulanarak morfin yoksunluğu tetiklendi.
Bulgular: Nukleus akumbens bölgesine lokal uygulanan topiramat naloksonla tetiklenen morfin yoksunluk bulgularından sıçrama sayısını ve ağırlık kaybını anlamlı düzeyde baskıladı. Lokal topiramat uygulaması yoksunluk bulgularından ıslak köpek silkinmesinde ise anlamlı değişiklik yapmadı. Topiramat mikroenjeksiyonları stereotipik hareketleri artırdığı halde vertikal hareketler, ambulatuvar hareketler ve toplam kat edilen mesafe gibi lokomotor aktivite davranışlarını değiştirmedi.
Sonuç: Bu bulgular antikonvülzan ilaç olan topiramatın nukleus akumbens bölgesine lokal enjeksiyonunun opioid yoksunluğunda etkili olduğunu, lokomotor aktivitede anlamı baskılanma yapmadan santral etkilerin yanı sıra periferik etkiler oluşturduğunu göstermektedir.
Keywords: antikonvülzan; morfin; nukleus akumbens; sıçrama; ağırlık kaybı; lokomotor aktivite

Kaynakça

  • Referans1 Mahluga Jafarova Demirkapu and Hasan Raci Yananli (February 27th 2020). Opium Alkaloids [Online First], IntechOpen, doi:10.5772/intechopen.91326. Available from: https://www.intechopen.com/online-first/opium-alkaloids. Referans2 Koob GF. Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci. 1992;13(5):177-184. Referans3 Gysling K, Wang RY. Morphine-induced activation of A10 dopamine neurons in the rat. Brain Res. 1983; 277(1):119-127. Referans4 Diana M, Pistis M, Muntoni A, Gessa G. Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats. J Pharmacol Exp Ther. 1995;272(2):781-785. Referans5 Yananli H, Gören MZ, Berkman K, Aricioğlu F. Effect of agmatine on brain L-citrulline production during morphine withdrawal in rats: A microdialysis study in nucleus accumbens. Brain Research. 2007;1132:51-58. doi:10.1016/j.brainres.2006.11.028 Referans6 Topkara B, Yananli HR, Sakallı E, Demirkapu MJ. Effects of injection of gamma-aminobutyric acid agonists into the nucleus accumbens on naloxone induced morphine withdrawal. Pharmacology. 2017;100:131-138. doi:10.1159/000477548 Referans7 Demirkapu MJ, Yananlı HR, Kaleli M, Sakalli HE, Gören MZ, Topkara B. The role of adenosine A1 receptors in the nucleus accumbens during morphine withdrawal. Clinical nad Experimental Pharmacology and Physiology 2020 Apr;47(4):553-560. doi:10.1111/1440-1681.13224 Referans8 Maryanoff BE. Sugar sulfamates for seizure control: discovery and development of topiramate, a structurally unique antiepileptic drug. Curr Top Med Chem. 2009;9(11):1049-1062. doi:10.2174/156802609789630938. Referans9 Shank RP, Gardocki JF, Streeter AJ, Maryanoff BE. An overview of the preclinical aspects of topiramate: pharmacology, pharmacokinetics, and mechanism of action. Epilepsia. 2000;41 Suppl 1:S3-9. Referans10 Wenzel RG, Schwarz K, Padiyara RS. Topiramate for migraine prevention. Pharmacotherapy. 2006 Mar;26(3):375-387. doi:10.1592/phco.26.3.375. Referans11 Verrotti A, Scaparrotta A, Agostinelli S, Di Pillo S, Chiarelli F, Grosso S. Topiramate-induced weight loss: a review. Epilepsy Res. 2011;95(3):189-199. doi:10.1016/j.eplepsyres.2011.05.014. Referans12 Arnone D. Review of the use of Topiramate for treatment of psychiatric disorders. Ann Gen Psychiatry. 2005;4(1):5. doi:10.1186/1744-859X-4-5. Referans13 Garnett WR. Clinical pharmacology of topiramate: a review. Epilepsia. 2000;41 Suppl 1:S61-65. Referans14 Chung JY, Kim MW, Kim M. Efficacy of zonisamide in migraineurs with nonresponse to topiramate. Biomed Res Int. 2014;2014:891348. doi:10.1155/2014/891348. Referans15 Walker MC, Sander JW. Topiramate: a new antiepileptic drug for refractory epilepsy. Seizure. 1996;5(3):199-203. Referans16 Zhang X, Velumian AA, Jones OT, Carlen PL. Modulation of high-voltage-activated calcium channels in dentate granule cells by topiramate. Epilepsia. 2000;41 Suppl 1:S52-60. Referans17 Mula M, Cavanna AE, Monaco F: Psychopharmacology of topiramate: from epilepsy to bipolar disorder. Neuropsychiatr Dis Treat. 2006;2(4):475-488. doi:10.2147/nedt.2006.2.4.475. Referans18 Maryanoff BE, McComsey DF, Costanzo MJ, Hochman C, Smith-Swintosky V, Shank RP. Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. J Med Chem. 2005;48(6):1941-1947. Referans19 Dodgson SJ, Shank RP, Maryanoff BE. Topiramate as an inhibitor of carbonic anhydrase isoenzymes. Epilepsia. 2000;41 Suppl 1:S35-39. doi:10.1111/j.1528-1157.2000.tb06047.x. Referans20 Nishimori I, Minakuchi T, Onishi S, Vullo D, Cecchi A, Scozzafava A, Supuran CT. Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides. Bioorg Med Chem. 2007;15(23):7229-7236. Referans21 Hargreaves GA, McGregor IS. Topiramate moderately reduces the motivation to consume alcohol and has a marked antidepressant effect in rats. Alcohol Clin Exp Res. 2007;31(11):1900-1907. Referans22 Zalewska-Kaszubska J, Bajer B, Gorska D, Andrzejczak D, Dyr W, Bieńkowski P. Effect of repeated treatment with topiramate on voluntary alcohol intake and beta-endorphin plasma level in Warsaw alcohol high-preferring rats. Psychopharmacology (Berl). 2013;225(2):275-281. doi:10.1007/s00213-012-2812-z. Referans23 Cagetti E, Baicy KJ, Olsen RW. Topiramate attenuates withdrawal signs after chronic intermittent ethanol in rats. Neuroreport. 2004;15(1):207-210. Referans24 Likhitsathian S, Uttawichai K, Booncharoen H, Wittayanookulluk A, Angkurawaranon C, Srisurapanont M. Topiramate treatment for alcoholic outpatients recently receiving residential treatment programs: a 12-week, randomized, placebo-controlled trial. Drug Alcohol Depend. 2013;133(2):440-446. doi:10.1016/j.drugalcdep.2013.06.032. Referans25 Johnson BA, Rosenthal N, Capece JA, Wiegand F, Mao L, Beyers K, McKay A, Ait-Daoud N, Anton RF, Ciraulo DA, Kranzler HR, Mann K, O'Malley SS, Swift RM. Topiramate for Alcoholism Advisory Board; Topiramate for Alcoholism Study Group. Topiramate for treating alcohol dependence: a randomized controlled trial. JAMA. 2007;298(14):1641-1651. Referans26 Baltieri DA, Daró FR, Ribeiro PL, Andrade AG. Effects of topiramate or naltrexone on tobacco use among male alcohol-dependent outpatients. Drug Alcohol Depend. 2009;105(1-2):33-41. doi: 10.1016/j.drugalcdep.2009.05.025. Referans27 Ma JZ, Johnson BA, Yu E, Weiss D, McSherry F, Saadvandi J, Iturriaga E, Ait-Daoud N, Rawson RA, Hrymoc M, Campbell J, Gorodetzky C, Haning W, Carlton B, Mawhinney J, Weis D, McCann M, Pham T, Stock C, Dickinson R, Elkashef A, Li MD. Fine-grain analysis of the treatment effect of topiramate on methamphetamine addiction with latent variable analysis. Drug Alcohol Depend. 2013;130(1-3):45-51. doi:10.1016/j.drugalcdep.2012.10.009. Referans28 Kampman KM, Pettinati H, Lynch KG, Dackis C, Sparkman T, Weigley C, O'Brien CP. A pilot trial of topiramate for the treatment of cocaine dependence. Drug Alcohol Depend. 2004;75(3):233-240. Referans29 Nuijten M, Blanken P, van den Brink W, Hendriks V. Treatment of crack-cocaine dependence with topiramate: a randomized controlled feasibility trial in The Netherlands. Drug Alcohol Depend. 2014;138:177-184. doi:10.1016/j.drugalcdep.2014.02.024. Referans30 Echeverry-Alzate V, Giné E, Bühler KM, Calleja-Conde J, Olmos P, Gorriti MA, Nadal R, Rodríguez de Fonseca F, López-Moreno JA. Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex. Br J Pharmacol. 2014;171(12):3023-3036. doi:10.1111/bph.12636. Referans31 Kampman KM, Pettinati HM, Lynch KG, Spratt K, Wierzbicki MR, O'Brien CP. A double-blind, placebo-controlled trial of topiramate for the treatment of comorbid cocaine and alcohol dependence. Drug Alcohol Depend. 2013;133(1):94-99.doi:10.1016/j.drugalcdep.2013.05.026. Referans32 Umbricht A, DeFulio A, Winstanley EL, Tompkins DA, Peirce J, Mintzer MZ, Strain EC, Bigelow GE. Topiramate for cocaine dependence during methadone maintenance treatment: a randomized controlled trial. Drug Alcohol Depend. 2014;140:92-100. doi:10.1016/j.drugalcdep.2014.03.033. Referans33 Levin FR, Mariani JJ, Pavlicova M, Choi CJ, Mahony AL, Brooks DJ, Bisaga A, Dakwar E, Carpenter KM, Naqvi N, Nunes EV, Kampman K. Extended release mixed amphetamine salts and topiramate for cocaine dependence: A randomized clinical replication trial with frequent users. Drug Alcohol Depend. 2020;206:107700. doi:10.1016/j.drugalcdep.2019.107700. Referans34 Medrano MC, Mendiguren A, Pineda J. Effect of ceftriaxone and topiramate treatments on naltrexone-precipitated morphine withdrawal and glutamate receptor desensitization in the rat locus coeruleus. Psychopharmacology (Berl). 2015;232(15):2795-2809. doi:10.1007/s00213-015-3913-2. Referans35 Hajhashemi V, Abed-Natanzi M. Effect of five common anticonvulsant drugs on naloxone-precipitated morphine withdrawal in mice. Res Pharm Sci. 2011;6(1):57-62. Referans36 Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates (fourth edition).Academic press, San Diego, California, 1998. Referans37 Bhargava I IN. Rapid induction and quantitation of morphine dependence in the rat by pellet implantation. Psychopharmacology 1977;52:55-62. Referans38 Zarrindast MR, Habibi M, Borzabadi S, Fazli-Tabaei S, Hossein Yahyavi S, Rostamin P. The effects of dopamine receptor agents on naloxone-induced jumping behaviour in morphine-dependent mice. Eur J Pharmacol. 2002;451(3):287-293. Referans39 Junqueira-Ayres DD, Asth L, Ayres AS, Lobão-Soares B, Soares-Rachetti VP, Gavioli EC. Topiramate reduces basal anxiety and relieves ethanol withdrawal-induced anxious behaviors in male rats. Exp Clin Psychopharmacol. 2017;25(2):105-113. doi:10.1037/pha0000118. Referans40 Sepúlveda J, Astorga JG, Contreras E. Riluzole decreases the abstinence syndrome and physical dependence in morphine-dependent mice. Eur J Pharmacol. 1999;379(1):59-62. Referans41 Zullino DF, Cottier AC, Besson J. Topiramate in opiate withdrawal. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Oct;26(6):1221-1223. Referans42 Gracy KN, Pickel VM Ultrastructural immunocytochemical localization of the N-methyl-D-aspartate receptor and tyrosine hydroxylase in the shell of the rat nucleus accumbens. Brain Res. 1996 Nov 01, 739(1-2):169-181. Referans43 Tarazi FI, Campbell A, Yeghiayan SK, Baldessarini RJ. Localization of ionotropic glutamate receptors in caudate-putamen and nucleus accumbenssepti of rat brain: comparison of NMDA, AMPA, and kainate receptors. Synapse. 1998; 30(2): 227-235. Referans44 Conrad KL, Tseng KY, Uejima JL, et al. Formation of accumbens GluR2- lacking AMPA receptors mediates incubation of cocaine craving. Nature. 2008;454(7200):118–121. Referans45 McCutcheon JE, Wang X, Tseng KY, Wolf ME, Marinelli M. Calciumpermeable AMPA receptors are present in nucleus accumbens synapses after prolonged withdrawal from cocaine self-administration but not experimenter-administered cocaine. J Neurosci. 2011;31(15): 5737–5743. Referans46 McLemore GL, Kest B, Inturrisi CE. The effects of LY293558, an AMPA receptor antagonist, on acute and chronic morphine dependence. Brain Res. 1997;778(1):120-126. Referans47 Ostadhadi S, Khan MI, Norouzi-Javidan A, Chamanara M, Jazaeri F, Zolfaghari S, Dehpour AR. Involvement of NMDA receptors and L-arginine/nitric oxide/cyclic guanosine monophosphate pathway in the antidepressant-like effects of topiramate in mice forced swimming test. Brain Res Bull. 2016 Apr;122:62-70. doi:10.1016/j.brainresbull.2016.03.004. Referans48 Jasinski DR, Johnson RE, Kocher TR. Clonidine in morphine withdrawal. Differential effects on signs and symptoms. Arch Gen Psychiatry. 1985;42(11):1063-1066. Referans49 Pappagallo M. Incidence, prevalence, and management of opioid bowel dysfunction. Am J Surg. 2001;182(5A Suppl):11S-18S. doi:10.1016/s0002-9610(01)00782-6. Referans50 Meissner W, Schmidt U, Hartmann M, et al. Oral naloxone reverses opioid-associated constipation. Pain 2000;84:105–109. Referans51 Fisher D, Grap MJ, Younger JB, Ameringer S, Elswick RK. Opioid withdrawal signs and symptoms in children: frequency and determinants. Heart Lung. 2013;42(6):407-13. doi:10.1016/j.hrtlng.2013.07.008. Referans52 Adams RE, Wooten GF. Dependence and withdrawal following intracerebroventricular and systemic morphine administration: functional anatomy and behavior. Brain Res. 1990;518(1-2):6-10. Referans53 Garner JP, Mason GJ. Evidence for a relationship between cage stereotypies and behavioural disinhibition in laboratory rodents. Behav Brain Res. 2002 17;136(1):83-92. doi:10.1016/s0166-4328(02)00111-0. Referans54 Pappas SS, Leventhal DK, Albin RL, Dauer WT. Mouse models of neurodevelopmental disease of the basal ganglia and associated circuits. Curr Top Dev Biol. 2014;109:97-169. doi:10.1016/B978-0-12-397920-9.00001-9. Referans55 Druhan JP, Walters CL, Aston-Jones G. Behavioral activation induced by D(2)-like receptor stimulation during opiate withdrawal. J Pharmacol Exp Ther. 2000;294(2):531-538. Referans56 Lee JM, DeLeon-Jones F, Fields JZ, Ritzmann RF. Cyclo (Leu-Gly) attenuates the striatal dopaminergic supersensitivity induced by chronic morphine. Alcohol Drug Res. 1987;7(1):1-10. Referans57 Hamlin AS, McNally GP, Westbrook RF, Osborne PB. Induction of Fos proteins in regions of the nucleus accumbens and ventrolateral striatum correlates with catalepsy and stereotypic behaviours induced by morphine. Neuropharmacology. 2009 Mar;56(4):798-807.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Songül Özkula

Oya Helin Dundar Bu kişi benim

Selcuk Erol Bu kişi benim

Ramazan Bakar Bu kişi benim

Heja Gecit Bu kişi benim

N. Eymen Turan Bu kişi benim

M. Fırat Balık Bu kişi benim

Hasan Yananlı 0000-0003-4649-3632

Rezzan Gülhan

Mahluga Jafarova Demirkapu

Yayımlanma Tarihi 23 Ağustos 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 8 Sayı: 2

Kaynak Göster

APA Özkula, S., Dundar, O. H., Erol, S., Bakar, R., vd. (2020). The effects of topiramate applied to the nucleus accumbens region on morphine withdrawal syndrome. Namık Kemal Tıp Dergisi, 8(2), 240-248. https://doi.org/10.37696/nkmj.714162
AMA Özkula S, Dundar OH, Erol S, Bakar R, Gecit H, Turan NE, Balık MF, Yananlı H, Gülhan R, Jafarova Demirkapu M. The effects of topiramate applied to the nucleus accumbens region on morphine withdrawal syndrome. NKMJ. Ağustos 2020;8(2):240-248. doi:10.37696/nkmj.714162
Chicago Özkula, Songül, Oya Helin Dundar, Selcuk Erol, Ramazan Bakar, Heja Gecit, N. Eymen Turan, M. Fırat Balık, Hasan Yananlı, Rezzan Gülhan, ve Mahluga Jafarova Demirkapu. “The Effects of Topiramate Applied to the Nucleus Accumbens Region on Morphine Withdrawal Syndrome”. Namık Kemal Tıp Dergisi 8, sy. 2 (Ağustos 2020): 240-48. https://doi.org/10.37696/nkmj.714162.
EndNote Özkula S, Dundar OH, Erol S, Bakar R, Gecit H, Turan NE, Balık MF, Yananlı H, Gülhan R, Jafarova Demirkapu M (01 Ağustos 2020) The effects of topiramate applied to the nucleus accumbens region on morphine withdrawal syndrome. Namık Kemal Tıp Dergisi 8 2 240–248.
IEEE S. Özkula, “The effects of topiramate applied to the nucleus accumbens region on morphine withdrawal syndrome”, NKMJ, c. 8, sy. 2, ss. 240–248, 2020, doi: 10.37696/nkmj.714162.
ISNAD Özkula, Songül vd. “The Effects of Topiramate Applied to the Nucleus Accumbens Region on Morphine Withdrawal Syndrome”. Namık Kemal Tıp Dergisi 8/2 (Ağustos 2020), 240-248. https://doi.org/10.37696/nkmj.714162.
JAMA Özkula S, Dundar OH, Erol S, Bakar R, Gecit H, Turan NE, Balık MF, Yananlı H, Gülhan R, Jafarova Demirkapu M. The effects of topiramate applied to the nucleus accumbens region on morphine withdrawal syndrome. NKMJ. 2020;8:240–248.
MLA Özkula, Songül vd. “The Effects of Topiramate Applied to the Nucleus Accumbens Region on Morphine Withdrawal Syndrome”. Namık Kemal Tıp Dergisi, c. 8, sy. 2, 2020, ss. 240-8, doi:10.37696/nkmj.714162.
Vancouver Özkula S, Dundar OH, Erol S, Bakar R, Gecit H, Turan NE, Balık MF, Yananlı H, Gülhan R, Jafarova Demirkapu M. The effects of topiramate applied to the nucleus accumbens region on morphine withdrawal syndrome. NKMJ. 2020;8(2):240-8.