GENOTOXIC EFFECTS OF SOME FOOD ADDITIVES ON MAMMALS

Yıl 2018, Cilt: 13 Sayı: 1, 43 - 50, 21.01.2018

Pinar Aksu Kılıçle , Özlem Önen

Öz

Food
additives are substances that are added to foods for many purposes such as
prevention of microbiological deterioration and increase of durability,
nutritive value preservation, assisting technological operations, correction of
sensory characteristics such as color, appearance, taste, smell. In this
review, it is aimed to summarize the data on the genotoxic effects of the
various food additives on the mammals and to provide a source for further work
to be done thereafter. It has been reported that food additives cause
genotoxicity compared to the results obtained from studies using various
genotoxicity tests. In vivo and in vitro studies, it has been determined that
additives increase genotoxicity and cytotoxicity depending on the applied dose.
As a result; in this review, various in vivo and in vitro studies have shown
that exposure to food additives is both genotoxic and cytotoxic on mammals,
where findings are generally parallel to each other as a result of assessed
studies.

Anahtar Kelimeler

Food Preservatives, Mammals, Genotoxic Effect, Microbiological Deterioration, Cytotoxicity

Kaynakça

• • Abe, S. and Sasaki, M., (1977). Chromosome Aberrations and Sister Chromatid Exchanges in Chinese Hamster Cells Exposed to Various Chemicals. J. Natl. Cancer I., 58, 1635-1643.
• • Altuğ T., (2001). Food Additives. Meta Press. Izmir, p. 1-137.
• • Altuğ, T., (2009). Food Additives. Kan Yılmaz Press, Izmir, Turkey, p:268.
• • Arslan, M., (2004). Effects of Boric acid on Invitro Chromosome Aberration and Sister Chromatid Exchange in Human Peripheral Lymphocytes. Master Thesis. Çukurova University, Institute of Science, Adana, p:1-62.
• • Bağcı, T., (1997). Effects on Food Additives and Health. Acta Medica, 28(1), 18-23.
• • Barlow, S., Pascal, G., Larsen, J.C., and Richold, M., (1999). (Eds.). Internatioal Life Sciences Institute (ILSI), Europe, Workshop on the Significance of Excursions of Intake Above the Accepted Daily Intake (ADI). Regul. Toxicol. Pharm., 30(No:2, Part2), 1-31 . ISBN: 1-57881-188-0.
• • Breiteneder, H., (2004). Thaumatin-Like Proteins-a New Family of Pollen and Fruit Allergens. Allergy, 59, 479-481.
• • Briggs, D.R., 1997, Food Additives. In: Food and Nutrition. M.L. Wahlgvist (Ed.). Allen & Unwin Pty Ltd. Australia.
• • Çelik, M., (2003). Cytogenetic Effects of Dinocap Fungicide on Allium cepa L. Root Cells and Human Peripheral Lymphocytes. PhD Thesis. Gazi University, Institute of Science, Ankara, pp. 1-102.
• • Güneşli, A., (2000). Piyasada Bulunan Toz İçeceklerde Bazı Boyalar (Tartrazin, Sunset Yellow, Allura Red) ve Koruyucuların (Sitrik Asit, Kalsiyum Fosfat) Analizi. Master Thesis. Ankara University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology.
• • Hasegawa, M., Nishi, Y., Ohkawa, Y., and Inui, N., (1984). Effects of Sorbic Acid and its Salts on Chromosome Aberrations, Sister Chromatid Exchanges and Gene Mutations in Cultured Chinese Hamster Cells. Food Chem. Toxicol., 22(7), 501-507.
• • Hedge, V.L. and Venkatesh, Y.P., 2004. Anaphylaxis to Excipient Mannitol: Evidence for an Immunoglobulin E-Mediated Mechanism. Clin. Exp. Allergy, 34, 1602-1609.
• • Hill, A.M. and Belsito, D.V., 2003. Systemic Contact Dermatitis of the Eyelids Caused by Formaldehyde Derived from Aspartame? Contact Dermatitis, 49, 258-259.
• • Ishidate, M.Jr., and Odashima, S., (1977). Chromosome Tests with 134 Compounds on Chinese Hamster Cells in Vitro-a Screening for Chemical Carcinogens. Mutat. Res., 48(3-4), 337-353.
• • Kaya, F.F., and Topaktaş, M., (2007). Genotoxic Effects of Potassium Bromate on Human Peripheral Lymphocytes in Vitro, Mutat. Res., 626, 48-52.
• • Luca, D., Luca, V., Cotor, F.l., and Răileanu, L., (1987). Invivo and Invitro Cytogenetic Damage Induced by Sodium Nitrite, Mutat. Res., 189(3), 333-339.
• • Mamur, S., (2009). Genotoxic Effects of Sodium Sorbate and Potassium Sorbate Used as Food Additives in Human Peripheral Lymphocytes. Master Thesis. Gazi Univesity, Institute of Science Ankara, p. 1-100.
• • Mamur, S., Yüzbaşioğlu, D., Unal, F., and YIlmaz, S., (2010). Does Potassium Sorbate Induce Genotoxic or Mutagenic Effects in Lympho¬cytes? Toxicol In Vitro, 24(3), 790-4.
• • Meng, Z., and Zhang, L., (1994). Chromosomal Aberrations, Sister Chromatid Exchanges and Micronuclei Induced Human Lymphocytes by Sodium Bisulfite (Sulfur dioxide), Acta. Genet. Sin., 21(1), 1-6.
• • Mpountoukas, P., Vantarakis, A., Sivridis, E., and Lialiaris, T., (2008). Cytogenetic study in Cultured Human Lymphocytes Treated with three Commonly used Preservatives. Food Chem. Toxicol., 46(7), 2390-2393.
• • Mukherjee, A., Giri, A.K., Talukder, G., and Sharma, A., (1988). Sister Chromatid Exchanges and Micronuclei Formations Induced by Sorbic acid and Sorbic Acid-Nitrite in Vivo in Mice. Toxicol. Let., 42(1), 47-53.
• • Özdemir, H., Turhan, A.B., and Arıkoğlu, H., (2012). Investigation of Genotoxic Effects of Potassium Sorbate, Sodium Benzoate and Sodium Nitrite. Eur. J. Basic Med. Sci., 2(2), 34-40.
• • Özkaya, İ., (2004). Food Additives and Toxins. In: Sağlıkta ve Hastalıkta Beslenme. Oşar, Z., and Erkan, T., (Eds.). Deomed Medical Press, Istanbul, pp. 39-44.
• • Parlak, Ş., (2007). Effects of Biphenyl, a Food Preservative, on Sister Chromatid Exchange, Chromosome Abnormality and Micronucleus Formation in Human Lymphocytes. Master Thesis, Çukurova University, Institute of Science, Department of Biology, Adana.
• • Prival, J.M., Simmon, F.V., and Mortelmans, E.K., (1991). Bacterial Mutage Nicity Testing of 49 Food Ingredients Gives Very Few Positive Results. Mutat. Res., 260, 321-329.
• • Saad, B., Bari, M.F., Saleh, M.I., Ahmad, K., and Talib, M.K.M., (2005). Simultaneous Determination of Preservatives (Benzoic acid, Sorbic acid, Methylparaben and Propylparaben) in Foodstuffs using High-Performance Liquid Choromatogra¬phy. J. Chromatogr. A, 1073, 393-7.
• • Sarıkaya, R. and Solak, K., (2003). Investigation of Genotoxicity of Somatic Mutation and Recombination Test of Benzoic Acid in Drosophila melanogaster, Journal of Gazi University-Education Faculty, 23(3), 19-32.
• • Sasaki, Y.F., Kawaguchi, S., Kamaya, A., Ohshita, M., Kabasawa, K., Iwama, K., Taniguchi, K., and Tsuda, S., (2002). “The Comet Assay with 8 Mouse Organs: Results With 39 Currently used Food Additives”, Mutat. Res., 519(1-2), 103–119.
• • Yaman, M., (1996). Investigation of the Amounts of Synthetic Paint Participating in Some Foodstuffs. PhD Thesis, Gazi University, Institute of Health Sciences, Department of Food Analysis and Nutrition Science, Ankara.
• • Yılmaz, E., (1999). Etiketlerde “E”leri Görmeye Alıştık, Bilim Teknik, pp:94-97.
• • Yılmaz, S., (2008). Genotoxic Effects of Some Food Additives. PhD Thesis, Gazi University, Institute of Science, Ankara, pp. 36-76.
• • Yurttagül M, and Ayaz A., (2008). Katkı Maddeleri: Yanlışlar ve Doğrular. Klasmat Press, Ankara, Türkiye, p. 32.
• • Yüzbaşıoğlu, D., Çelik, M., Yılmaz, S., Ünal, F., and Aksoy, H., (2006). Clastogenicity of the Fungicide Afugan in Cultured Human Lymphocytes. Mutat. Res., 604 (1-2), 53-59.
• • Zengin N., Yüzbaşıoğlu D., Ünal F., Yılmaz S., and Aksoy H., 2011. The Evaluation of the Genotoxicity of Two Food Preservatives: Sodium Benzoate and Potassium Benzoate Food and Chemical Toxicology, 49, 763–769.