Determination of Swelling Kinetics and Diffusion Mechanisms of Chemically Crosslinked Porous Chitosan Hydrogels

Yıl 2024, Cilt: 9 Sayı: 2, 106 - 118

Hanife Songül Kaçoğlu , Özgür Ceylan , Mithat Çelebi

https://doi.org/10.56171/ojn.1488770

Öz

Chitosan hydrogels have gained popularity in a variety of industrial applications due to their biocompatibility, biodegradability, and varied physicochemical features. Understanding these hydrogels' swelling dynamics and diffusion processes is crucial for improving their efficacy in drug delivery, tissue engineering, and wound healing. This work aims to examine the processes of swelling and diffusion in chemically crosslinked porous chitosan hydrogels. The swelling kinetics of the hydrogels were investigated using Fick's diffusion mathematical model to determine the effects of different molecular weights of chitosan on the swelling behavior at pH: 2.0, pH: 5.6 and pH: 7.4. Chitosan hydrogels cross-linked with glutaraldeyhde showed Super Case II Diffusion according to Fick's laws of diffusion.

Anahtar Kelimeler

hydrogel, freeze-drying, Fick’s law, swelling kinetic, diffusion coefficient

Destekleyen Kurum

This study was supported with Yalova University BAPKO Graduate Thesis Project (2020/YL/0025).

Proje Numarası

Yalova University BAPKO Graduate Thesis Project (2020/YL/0025).

Kimyasal Olarak Çapraz Bağlı Gözenekli Kitosan Hidrojellerin Şişme Kinetiği ve Difüzyon Mekanizmalarının Belirlenmesi

Öz

Kitosan hidrojelleri biyouyumlulukları, biyobozunurlukları ve çeşitli fizikokimyasal özelliklerinden dolayı çeşitli endüstriyel uygulamalarda popülerlik kazanmıştır. Bu hidrojellerin şişme dinamiklerini ve difüzyon süreçlerini anlamak, ilaç dağıtımı, doku mühendisliği ve yara iyileşmesindeki etkinliklerinin arttırılması açısından çok önemlidir. Bu çalışma kimyasal olarak çapraz bağlı gözenekli kitosan hidrojellerde şişme ve difüzyon süreçlerini incelemeyi amaçlamaktadır. Hidrojellerin şişme kinetiği, pH: 2.0, pH: 5.6 ve pH: 7.4’ te kitosanın farklı moleküler ağırlıklarının şişme davranışı üzerindeki etkilerini belirlemek için Fick Kanunu difüzyon matematiksel modeli kullanılarak araştırıldı. Glutaraldehid ile çapraz bağlanan kitosan hidrojelleri, Fick'in difüzyon yasalarına göre Süper Durum II Difüzyonu gösterdi.

Anahtar Kelimeler

hidrojel, dondurarak kurutma, Fick Yasası, şişme kinetiği, diffüzyon katsayısı

Proje Numarası

Yalova University BAPKO Graduate Thesis Project (2020/YL/0025).

Kaynakça

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