Endemic Equilibrium of Feline Leukemia Virus

Yıl 2022, Cilt: 5 Sayı: 2, 850 - 860, 18.07.2022

Ayse Peker-dobie

https://doi.org/10.47495/okufbed.1064514

Öz

Feline Leukemia Virus impairs the immune system of cats, and as a result of the immunosuppression characteristic of the virus, infected cats are under a greater risk for developing serious diseases like lymphomas, leukemia, severe erythroid hypoplasia and anemia. The compartmental model denoted by SI_1 I_2 based on the epidemiological model Susceptible-Infected (SI) is used to investigate the endemic equilibrium of the disease for stray cats without vaccination and treatment. The conditions for parameters are obtained such that the final value of infected cats' population is higher than the final value of susceptible cats.

Anahtar Kelimeler

Epidemic models, Susceptible-Infected model, Feline Leukemia Virus, Endemic equilibrium

Kedi Lösemi Virüsünde Endemik Denge

Öz

Felin Lösemi Virüsü kedilerin bağışıklık sistemini zayıflatan bir virüstür ve virüsün bağışıklık sistemini baskılayan yapısı nedeniyle, virüsle enfekte olmuş kediler lenfoma, lösemi, ağır eritroid hipoplazi ve anemi gibi ciddi hastalıkların ortaya çıkması riskini daha fazla taşırlar. Duyarlı-Enfekte (SI) epidemik modeline dayalı SI_1 I_2 kompartıman modeli, aşılama ve tedavinin olmadığı durumlarda, sokak kedileri için hastalığın endemik dengesini incelemek üzere kullanılmıştır. Hastalıklı kedi popülasyonunun duyarlı kedilerin final değerinden daha büyük olduğu parametre koşulları elde edilmiştir.

Anahtar Kelimeler

Epidemik modeller, Duyarlı-Enfekte modeli, Felin Lösemi Virüsü, Endemik denge

Kaynakça

• Addie, D.D., Toth, S., Reid, S., Jarrett, O., Dennis, J.M. and Callanan, J.J. Long-term impact on a closed household of pet cats of natural infection with feline coronavirus, feline leukaemia virus and feline immunodeficiency virus. Veterinary Record 2000; 146(15):419-424.
• Ahmetolan, S., Bilge, A.H., Demirci, A. and Dobie, A.P. A Susceptible-Infectious (SI) model with two infective stages and an endemic equilibrium. Mathematics and Computers in Simulation 2022;194 :19-35.
• Bande, F., Arshad, S.S., Hassan, L., Zakaria, Z., Sapian, N.A., Rahman, N.A. and Alazawy, A. Prevalence and risk factors of feline leukaemia virus and feline immunodeficiency virus in peninsular Malaysia. BMC Veterinary Research 2012; 8(1):1-6.
• Dunham, S.P. and Graham, E. Retroviral infections of small animals. Veterinary Clinics of North America: Small Animal Practice 2008; 38(4):879-901.
• Hal, S. The geographical distribution of animal viral diseases. Elsevier 2012.
• Hardy, W.D., Hess, P.W., MacEwen, E.G., McClelland, A.J., Zuckerman, E.E., Essex, M., Cotter, S.M. and Jarrett, O. Biology of feline leukemia virus in the natural environment. Cancer Research 1976; 36(2 Part 2):582-588.
• Helfer-Hungerbuehler, A.K., Widmer, S., Kessler, Y., Riond, B., Boretti, F.S., Grest, P., Lutz, H. and Hofmann-Lehmann, R. Long-term follow up of feline leukemia virus infection and characterization of viral RNA loads using molecular methods in tissues of cats with different infection outcomes. Virus research 2015; 197:137-150.
• James, N. FENNER'S VETERINARY VIROLOGY. Elsevier Academic Press 2017.
• Jarrett, O., Laird, H.M. and Hay, D. Determinants of the host range of feline leukaemia viruses. Journal of General Virology 1973; 20(2):169-175.
• Jarrett, O. Pathogenicity of feline leukemia virus is commonly associated with variant viruses. Leukemia 1992; 6:153S-154S.
• Kipar, A., Kremendahl, J., Jackson, M.L. and Reinacher, M. Comparative examination of cats with feline leukemia virus-associated enteritis and other relevant forms of feline enteritis. Veterinary pathology 2001; 38(4):359-371.
• Lee, I.T., Levy, J.K., Gorman, S.P., Crawford, P.C. and Slater, M.R. Prevalence of feline leukemia virus infection and serum antibodies against feline immunodeficiency virus in unowned free-roaming cats. Journal of the American Veterinary Medical Association 2002; 220(5):620-622.
• Levy, J., Crawford, C., Hartmann, K., Hofmann-Lehmann, R., Little, S., Sundahl, E. and Thayer, V. 2008 American Association of Feline Practitioners' feline retrovirus management guidelines. Journal of Feline Medicine and Surgery 2008; 10(3):300-316.
• Macy, D.W. and Henry, C.I. I SECTION c Cancer-Causing Viruses. Withrow and MacEwen's Small Animal Clinical Oncology 2012;20.
• Neil, J.C. Feline leukemia and sarcoma viruses. Desk Encyclopedia of 2008; 283.
• Sarma, P.S. and Log, T. Subgroup classification of feline leukemia and sarcoma viruses by viral interference and neutralization tests. Virology 1973; 54(1):160-169.
• Ueland, K., and Lutz, H. Prevalence of feline leukemia virus and antibodies to feline immunodeficiency virus in cats in Norway. Journal of Veterinary Medicine Series B 1992; 39.1-10:53-58.