Kahve Tüketiminin Meme Kanserine Karşı Koruyucu Etkisi

Yıl 2024, Cilt: 7 Sayı: 4, 1851 - 1859, 16.09.2024

Deniz Tazeoğlu , Fatma Bengu Kuyulu Bozdogan Aybala Tazeoğlu

https://doi.org/10.47495/okufbed.1406123

Öz

Meme kanseri gelişiminde önemli risk faktörü tanımlanmaktadır. Öte yandan koruyucu faktörler de güncel araştırmaların konusu olmaktadır. Bu nedenle, bu çalışmada kadınlardaki kahve tüketiminin meme kanserine karşı koruyucu etkisinin araştırılması amaçlanmıştır. Ocak 2022-Mayıs 2022 tarihleri arasında Onkoloji kliniğinde meme kanseri tanısıyla takip edilen (1. grup, n=72) ve meme ile ilgili herhangi bir hastalığı veya şikâyeti olmayan (2. grup, n=212) kontrol grubundaki kadın hastalar gözlemsel olarak incelenmiştir. Hastaların demografik verileri (yaş, cinsiyet), yandaş hastalık varlığı, menopoz durumu, beden kütle indeksi (BKİ), toplam vücut ve gövde yağ oranları (%) ile kahve tüketim miktarları kaydedilmiştir. Hastaların yaşları ortalama 49,68±11,43 yıl olarak bulunmuştur. Kontrol grubundaki hastaların kahve tüketimleri, 1. gruptakilere kıyasla daha fazla tespit edilmiştir (p=0,01). Günlük kahve tüketimi ile meme kanseri gelişme oranı arasında negatif ve anlamlı bir ilişki olduğu gözlenmiştir (p<0,05). Sonuç olarak; kadınlarda görülen meme kanseri ile kahve tüketimi arasında ilişki olduğu tespit edilmiştir. Kahve tüketiminin meme kanserine karşı koruyucu etkisinin olabileceğine dair bulguların epidemiyolojik çalışmalar ile desteklenmesine ihtiyaç vardır.

Anahtar Kelimeler

meme kanseri, kahve, neoplazmlar, risk

Etik Beyan

Çalışma Osmaniye Korkut Ata Üniversitesi Etik Kurulu'na sunularak çalışma onayı alındı (no: 2023/7/13).

Protective Effect of Coffee Consumption on Breast Cancer

Öz

Important risk factors for the development of breast cancer are identified. On the other hand, protective factors are also the subject of current research. Therefore, this study aimed to investigate the protective effect of coffee consumption in women against breast cancer. Female patients in the control group who were followed up with a diagnosis of breast cancer in the Oncology clinic between January 2022 and May 2022 (group 1, n=72) and did not have any breast-related disease or complaints (group 2, n=212) were examined observationally. Demographic data of the patients (age, gender), presence of comorbidities, menopausal status, Body Mass Index (BMI), total body and trunk fat percentages (%), and coffee consumption amounts were recorded. The average age of the patients was found to be 49.68±11.43 years. The coffee consumption of the patients in the control group was determined to be higher compared to those in the 1st group (p = 0.01). It was observed that there was a negative and significant relationship between daily coffee consumption and breast cancer development rate (p<0.05). In conclusion; It has been determined that there is a relationship between breast cancer in women and coffee consumption. Findings that coffee consumption may have a protective effect against breast cancer need to be supported by epidemiological studies.

Anahtar Kelimeler

breast cancer, coffee, neoplasms, risk

Etik Beyan

The study was submitted to Osmaniye Korkut Ata University Ethics Committee and study approval was received (no: 2023/7/13).

Kaynakça

• Alicandro G., Tavani A., La Vecchia C. Coffee and cancer risk: a summary overview. Eur J Cancer Prev. 2017; Sep;26(5):424-432. doi: 10.1097/CEJ.0000000000000341.
• Ellingjord-Dale M., Papadimitriou N., Katsoulis M., Yee C., Dimou N., Gill D., Aune D., Ong JS., MacGregor S., Elsworth B., Lewis SJ., Martin RM., Riboli E., Tsilidis KK. Coffee consumption and risk of breast cancer: A Mendelian randomization study. PLoS One. 2021; Jan 19;16(1):e0236904. doi: 10.1371/journal.pone.0236904.
• Feigelson HS., Caan B., Weinmann S., Leonard AC., Powers JD., Yenumula PR., Arterburn DE., Koebnick C., Altaye M., Schauer DP. Bariatric Surgery is Associated With Reduced Risk of Breast Cancer in Both Premenopausal and Postmenopausal Women. Ann Surg. 2020; Dec;272(6):1053-1059. doi: 10.1097/SLA.0000000000003331.
• Godos J., Micek A., Marranzano M., Salomone F., Rio DD., Ray S. Coffee Consumption and Risk of Biliary Tract Cancers and Liver Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies. Nutrients 2017; Aug 28;9(9):950. doi: 10.3390/nu9090950.
• Grosso G., Godos J., Lamuela-Raventos R., Ray S., Micek A., Pajak A., Sciacca S., D'Orazio N., Del Rio D., Galvano F. A comprehensive meta-analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations. Mol Nutr Food Res. 2017; Apr;61(4). doi: 10.1002/mnfr.201600930.
• Gunter MJ., Xie X., Xue X., Kabat GC., Rohan TE., Wassertheil-Smoller S., Ho GY., Wylie-Rosett J., Greco T., Yu H., Beasley J., Strickler HD. Breast cancer risk in metabolically healthy but overweight postmenopausal women. Cancer Res. 2015; Jan 15;75(2):270-4. doi: 10.1158/0008-5472.CAN-14-2317.
• Halvorsen BL., Carlsen MH., Phillips KM., Bøhn SK., Holte K., Jacobs DR Jr., Blomhoff R. Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States. Am J Clin Nutr. 2006; Jul;84(1):95-135. doi: 10.1093/ajcn/84.1.95.
• Harding JL., Shaw JE., Anstey KJ., Adams R., Balkau B., Brennan-Olsen SL., Briffa T., Davis TM., Davis WA., Dobson A., Flicker L., Giles G., Grant J., Huxley R., Knuiman M., Luszcz M., MacInnis RJ., Mitchell P., Pasco JA., Reid C., Simmons D., Simons L., Tonkin A., Woodward M., Peeters A., Magliano DJ. Comparison of anthropometric measures as predictors of cancer incidence: A pooled collaborative analysis of 11 Australian cohorts. Int J Cancer. 2015; Oct 1;137(7):1699-708. doi: 10.1002/ijc.29529.
• Jiang W., Wu Y., Jiang X. Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies. Gynecol Oncol. 2013; Jun;129(3):620-9. doi: 10.1016/j.ygyno.2013.03.014. Lafranconi A., Micek A., De Paoli P., Bimonte S., Rossi P., Quagliariello V., Berretta M. Coffee Intake Decreases Risk of Postmenopausal Breast Cancer: A Dose-Response Meta-Analysis on Prospective Cohort Studies. Nutrients. 2018; Jan 23;10(2):112. doi: 10.3390/nu10020112.
• Li XJ., Ren ZJ., Qin JW., Zhao JH., Tang JH., Ji MH., Wu JZ. Coffee consumption and risk of breast cancer: an up-to-date meta-analysis. PLoS One. 2013;8(1):e52681. doi: 10.1371/journal.pone.0052681.
• Ling CH., de Craen AJ., Slagboom PE., Gunn DA., Stokkel MP., Westendorp RG., Maier AB. Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population. Clin Nutr. 2011; Oct;30(5):610-5. doi: 10.1016/j.clnu.2011.04.001. Epub 2011 May 8. PMID: 21555168.
• Liu M., Song SS., Park S. Coffee Intake Interacted with the Bcl-2 rs1944420, rs7236090, and rs2849382 Haplotype to Influence Breast Cancer Risk in Middle-Aged Women. Nutr Cancer. 2022;74(1):131-140. doi: 10.1080/01635581.2021.1871926.
• Lowcock EC., Cotterchio M., Anderson LN., Boucher BA., El-Sohemy A. High coffee intake, but not caffeine, is associated with reduced estrogen receptor negative and postmenopausal breast cancer risk with no effect modification by CYP1A2 genotype. Nutr Cancer. 2013;65(3):398-409. doi: 10.1080/01635581.2013.768348.
• Marventano S, Salomone F, Godos J, Pluchinotta F, Del Rio D, Mistretta A, Grosso G. Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies. Clin Nutr. 2016 Dec;35(6):1269-1281. doi: 10.1016/j.clnu.2016.03.012.
• Mehta LS., Watson KE., Barac A., Beckie TM., Bittner V., Cruz-Flores S., Dent S., Kondapalli L., Ky B., Okwuosa T., Piña IL., Volgman AS. American Heart Association Cardiovascular Disease in Women and Special Populations Committee of the Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; and Council on Quality of Care and Outcomes Research. Cardiovascular Disease and Breast Cancer: Where These Entities Intersect: A Scientific Statement From the American Heart Association. Circulation. 2018; Feb 20;137(8):e30-e66. doi: 10.1161/CIR.0000000000000556.
• Moslehi JJ. Cardiovascular Toxic Effects of Targeted Cancer Therapies. N Engl J Med. 2016;Oct 13;375(15):1457-1467. doi: 10.1056/NEJMra1100265.
• Palmioli A., Ciaramelli C., Tisi R., Spinelli M., De Sanctis G., Sacco E., Airoldi C. Natural Compounds in Cancer Prevention: Effects of Coffee Extracts and Their Main Polyphenolic Component, 5-O-Caffeoylquinic Acid, on Oncogenic Ras Proteins. Chem Asian J. 2017; Sep 19;12(18):2457-2466. doi: 10.1002/asia.201700844.
• Steele CB., Thomas CC., Henley SJ., Massetti GM., Galuska DA., Agurs-Collins T., Puckett M., Richardson LC. Vital Signs: Trends in Incidence of Cancers Associated with Overweight and Obesity - United States, 2005-2014. MMWR Morb Mortal Wkly Rep. 2017; Oct 3;66(39):1052-1058. doi: 10.15585/mmwr.mm6639e1.
• Svilaas A., Sakhi AK., Andersen LF., Svilaas T., Ström EC., Jacobs DR Jr., Ose L., Blomhoff R. Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J Nutr. 2004;Mar;134(3):562-7. doi: 10.1093/jn/134.3.562.
• Tamaki K., Tamaki N., Terukina S., Kamada Y., Uehara K., Arakaki M., Miyashita M., Ishida T., McNamara KM., Ohuchi N., Sasano H. The correlation between body mass index and breast cancer risk or estrogen receptor status in Okinawan women. Tohoku J Exp Med. 2014; Nov;234(3):169-74. doi: 10.1620/tjem.234.169.
• Tian C., Wang W., Hong Z., Zhang X. Coffee consumption and risk of colorectal cancer: a dose-response analysis of observational studies. Cancer Causes Control 2013; 24(6): 1265-8
• Van’t Veer P., Kampman E. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. World Cancer Research Fund/American Institute for Cancer Research 2007.
• Yaghjyan L., Rich S., Mao L., Mai V., Egan KM. Interactions of coffee consumption and postmenopausal hormone use in relation to breast cancer risk in UK Biobank. Cancer Causes Control. 2018; Jun;29(6):519-525. doi: 10.1007/s10552-018-1028-x.
• Yu X., Bao Z., Zou J., Dong J. Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer 2011; Mar 15;11:96. doi: 10.1186/1471-2407-11-96.
• Zheng KH., Zhu K., Wactawski-Wende J., Freudenheim JL., LaMonte MJ., Hovey KM., Mu L. Caffeine intake from coffee and tea and invasive breast cancer incidence among postmenopausal women in the Women's Health Initiative. Int J Cancer. 2021; Dec 15;149(12):2032-2044. doi: 10.1002/ijc.33771.