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Histolojik değişiklikler Klorprifos Kurkumin Rat Seminifer tübül
In this study, effect
of commonly used pesticide
chlorpyrifos’s (CPF) on mammalian testicular tissue damage and antioxidant
curcumin’s effects on damage reducing were investigated. For this purpose, 90
days old 48 male rats (Wistar albino) primarily divided into two groups;
treated for 15 days and treated for 30 days. These groups divided into four
groups within themselves, included; a control, only CPF, CPF + curcumin and
only curcumin groups, respectively. On the 15th and 30th
days 6 animals’ testicular tissue from each group were taken and placed in 10%
neutral buffered formalin for histological procedures and evaluated by light
microscopy. It was determined that the CPF group had histopathological changes
such as seminiferous tubule degeneration, reduction of germ cells in
seminiferous tubules, oedema in connective tissue in inter seminiferous tubules
region and necrosis compared to control group. Also, it was observed that CPF
and curcumin group had minor histopathological changes on these tissues
according to only CPF group. There were statistically significant differences
between control group and CPF and CPF + CUR groups as well as between CPF group
and CPF + KUR group (p<0.05). The findings revealed that CPF caused damage in
testicular tissues and curcumin had significant antioxidant effects on this
damage.
Histological changes Chlorpyrifos Curcumin Rat Seminiferous tubules Testicular tissue
Bölüm | Zootekni |
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Yazarlar | |
Yayımlanma Tarihi | 14 Şubat 2017 |
Kabul Tarihi | 11 Kasım 2016 |
Yayımlandığı Sayı | Yıl 2017 Cilt: 32 Sayı: 1 |