Elit Atletlerde SOD2 Rs4880 Polimorfizminin Yarışma Performansı ile İlişkisi

Öz

SOD2 rs4880 polimorfizmi, farklı popülasyonlarda, atletlerin atletik performanslarıyla sıkça ilişkilendirilen varyantlardandır. Ancak, Türk elit atletlerde, bu varyantın atletik performans üzerine etkisine yönelik herhangi bir çalışma yoktur. Bu nedenle, sunulan çalışmanın amacı, elit atletlerde, SOD2 rs4880 polimorfizminin yarışma performansı üzerindeki olası etkilerini açığa çıkartmayı amaçlamaktadır. Çalışmaya 18-35 yaşları arasında 31 sprint/güç ve 29 dayanıklılık olmak üzere toplam 60 elit atlet ve 20 sedanter birey dahil edilmiştir. Atletlerin yarışma performansları/bireysel en iyi dereceleri (PB), Dünya Atletizm (WA) birliğinin performans puanlama sistemine göre belirlenmiştir. Katılımcıların kanlarından izole edilen genomik DNA ile tüm ekzom dizileme (WES) gerçekleştirilmiştir. Spor branşı, cinsiyet ve yarışma performansı, doğrusal regresyon modeli ile grup içi ve gruplar arası kıyaslanan parametreler olarak seçilmiştir. Grup içinde ve gruplar arasında, alel ve genotip frekansları arasında bir farklılık görülmemiştir. Sprint/güç grubu atletlerde, yarışma performansı ile genotip frekansı arasında anlamlı bir ilişki görülmezken dayanıklılık grubu atletlerde, rs4880 polimorfizminin yarışma performansı ile istatistiksel olarak anlamlı bir şekilde (p=0.049) ilişkili olduğu görülmüştür. Bu çalışma ile SOD2 rs4880 polimorfizminin dayanıklılık branşı ile ilişkili olabileceği söylenebilir. Yine de çok katılımlı bir grupla diğer genetik varyasyonların dahiliyle ileri çalışmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler

• Sporcular
• Atletik Performans
• Atletizm
• rs4880 Polimorfizm
• SOD2

Association of SOD2 Polymorphism (Rs4880) and Competitive Performance in Track and Field Athletes

Öz

The rs4880 polymorphism in the SOD2 gene has frequently been associated with the athletic performance of the athletes in different populations. However, there were not any studies in the Turkish elite athletes. Thus, the aim of the study is to evaluate the impacts of SOD2 rs4880 polymorphism on competitive performance of Turkish elite athletes. A total of 60 elite athletes (31 sprint/power and 29 endurance) and 20 controls with the ages of 18-35 voluntarily participated in the study. World Athletics (WA) score table was used to determine the performance levels of the competitive performance/personal best (PB) of the athletes. Whole exome sequencing (WES) was performed by the genomic DNA isolated from peripheral blood of the participants. Sport type, sex and competitive performance were chosen as the parameters to compare within and between the groups by linear regression models. There were not any significances between the genotype and allele frequencies. Finally, there were not any associations between competitive performance and genotype frequencies within the sprint/power athletes while competitive performance was significantly (p=0.049) correlated with rs4880 polymorphism according to the over-dominant model within the endurance athletes. The rs4880 polymorphism in the SOD2 gene may be linked to the competitive performance of the endurance athletes. Still, further studies with more participants and analyzing multiple factors are needed.

Anahtar Kelimeler

• Athlete
• Athletic Performance
• Athletics
• rs4880 Polymorphism
• SOD2

Kaynakça

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