İzopropil-Tiyosemikarbazon Bazlı Yeni İzatin Türevleri: Sentez, Spektroskopik Karakterizasyon ve Teorik Çalışmalar

Yıl 2025, Cilt: 15 Sayı: 2, 339 - 351, 27.12.2025

Hasan Yakan

https://doi.org/10.54370/ordubtd.1771474

Öz

İzopropil-tiyosemikarbazon (1–8) bazlı bir dizi izatin türevi, çeşitli izatin türevlerinin N-izopropilhidrazinkarbotiyoamid ile reaksiyonu yoluyla sentezlendi. Tiyosemikarbazit ara ürünü, izopropil izotiyosiyanatın hidrazin monohidrat ile reaksiyona sokulmasıyla elde edildi. Sentezlenen bileşiklerin yapısal karakterizasyonu ve saflık değerlendirmesi, 1H ve 13C NMR, FT-IR spektroskopisi ve elementel analiz kullanılarak gerçekleştirildi. Ayrıca, bileşiklerin kararlılığı ve reaktivitesini aydınlatmak için DFT hesaplamaları yapıldı ve sonuçlar, bileşiklerin yapısal ve elektronik karakterizasyonunu karşılaştırmalı olarak analiz etmek için kullanıldı.

Anahtar Kelimeler

izatin , tiyosemikarbazon , spektroskopik teknikler , DFT hesaplamaları

Proje Numarası

No, there is no project support.

New Isatin Derivatives Based Isopropyl-Thiosemicarbazone: Synthesis, Spectroscopic Characterization, and Theoretical Studies

Öz

A series of isatin derivatives based isopropyl-thiosemicarbazone (4–11) were synthesized through the reaction of various isatin derivatives with N-isopropylhydrazinecarbothioamide. The thiosemicarbazide intermediate was obtained by reacting isopropyl isothiocyanate with hydrazine monohydrate. Structural characterization and purity assessment of the synthesized compounds were performed using 1H and 13C NMR, FT-IR spectroscopy, and elemental analysis. Furthermore, to shed light on the stability and reactivity of the compounds, DFT calculations were performed, and the results were used to comparatively analyse the structural and electronic characterization of the compounds.

Anahtar Kelimeler

isatin , thiosemicarbazone , spectroscopic techniques , DFT calculations

Etik Beyan

There are no ethical issues with the publication of this article.

Destekleyen Kurum

This study was not supported by any organization.

Proje Numarası

No, there is no project support.

Teşekkür

I would like to thank Prof. Dr. M. Serdar Çavuş for theoretical study.

Kaynakça

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