Bone-minerale metabolism disorders (renal osteodystrophy) in chronic kidney disease and treatment approach

Yıl 2016, Cilt: 8 Sayı: 4, 214 - 217, 01.12.2016

Turgut Kültür , Aydın Çifci , Ahmet İnanır

https://doi.org/10.21601/ortadogutipdergisi.272239

Öz

When renal functions decrease with
the ongoing parenchymal loss in chronic renal disease impairement of bone-
mineral metabolism occurs. Secondary hyperparathyroidism is there all cause
of  this situation, and this case is
called renal osteodystrophia. In this disease there are vitamin D deficiency,
phosphate retension, hypocalcemia, 
mineral  metabolism impairement
due to secondary hyperparathyroidism, disturbance in the bone structure and
vascular and/or  soft tissue
calcification, metastatic calcifications. Renal osteodystrophia is important in
chronic kidney disease  patients as it
not only disturbs the quality of  life
of  the patients  but also decreases  the survey of 
the patients. 

Anahtar Kelimeler

Chronic kidney disease, bone mineral metabolism disorders

Kronik böbrek hastalığında kemik-mineral metabolizması bozuklukları (renal osteodistrofi) ve tedavi yaklaşımı

Öz

Kronik böbrek hastalığında devam
eden parankim kaybı nedeniyle böbrek fonksiyonları azaldıkça kemik-mineral
metabolizmasında bozulmalar olmaktadır. Bu durumu oluşturan temel neden sekonder
hiperparatiroididir ve bu tabloya da renal osteodistrofi denilmektedir. Bu
tabloda vitamin D eksikliği, fosfat retansiyonu, hipokalsemi, sekonder
hiperparatiroidinin oluşturduğu mineral metabolizması bozukluğu, kemik
yapısında bozulma ile beraber vasküler ve/veya yumuşak doku kalsifikasyonları,
metastatik kalsifikasyonlar söz konusudur. Renal osteodistrofi kronik böbrek
hastalarında hem yaşam kalitesini düşürmesi 
hem de yaşam süresini kısaltıyor olması nedeniyle önem arz etmektedir.

Anahtar Kelimeler

Kronik böbrek hastalığı, kemik mineral metobolizması bozuklukları

Kaynakça

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