Primer hiperparatiroidide adenom hacmi ile laboratuvar parametreleri ve kardiyo-metabolik risk faktörlerinin ilişkisi

Yıl 2018, Cilt: 10 Sayı: 1, 13 - 19, 01.12.2018

Muhammed Kizilgul , Mustafa Caliskan , Bekır Ucan , Erkam Sencar Davut Sakiz Erman Cakal Mustafa Ozbek

https://doi.org/10.21601/ortadogutipdergisi.344895

Öz

Amaç: Primer hiperparatiroidili hastalarda, paratiroid adenom ağırlığı
veya hacminin hiperparatiroidinin biyokimyasal parametreleri ile
ilişkisini araştıran çalışmaların sonuçları çelişkilidir. Bu çalışmada, primer hiperparatiroidili
hastalarda preoperatif adenom hacmi ile labaratuvar parametreleri ve kardiyo-metabolik
risk faktörleri arasındaki ilişkinin değerlendirilmesini amaçladık.

 

Gereç ve Yöntemler: Çalışmaya primer hiperparatiroidisi olan 75 hasta ve 96 kontrol olgusu alındı.
Demografik, antropometrik ve biyokimyasal veriler kaydedildi. Adenom hacmi ile
labaratuvar ve kardiyo-metabolik risk faktörleri arasındaki ilişki korrelasyon
analizi ile değerlendirildi. Preoperatif adenoma hacmi ellipsoid model formülü
ile hesaplandı.

 

Sonuçlar: Ortalama yaş her iki grupta
benzerdi (52.69 ± 10.91 to 53.33 ± 7.70, p:0.667). Ortalama adenom hacmi 1.42 ± 2.62 cm³ idi. Paratiroid adenom
hacmi, parathormon ve kalsiyum düzeyleri ile pozitif korrele iken, vitamin D
düzeyleri ile negatif korrele idi (p<0.05). Paratiroid adenom hacmi, kardiyo-metabolik
risk faktörleri olan sistolik ve diyastolik kan basıncı, yaş, açlık plazma
glukozu, lipid profili, vücut kitle indeksi, karotis intima media kalınlığı,
CRP ve HOMA-IR ile ilişkili değildi (p>0.05).
Parathormon, kalsiyum,
fosfor veya vitamin D düzeyleri ile kardiyo-metabolik risk faktörleri arasında
ilişki saptanmadı (p>0.05).

 

Sonuç: Paratiroid adenoma hacmi ile parathormon, kalsiyum ve
vitamin D düzeyleri arasında korrelasyon olmasına rağmen paratiroid adenoma hacmi
ile kardiyo-metabolik
risk faktörleri arasında ilişki saptanmadı.

Anahtar Kelimeler

Primer hiperparatiroidi, adenoma hacmi, kardiyometabolik risk faktörleri

The association of adenoma size with the biochemical parameters and cardio-metabolic risk factors in primary hyperparathyroidism

Öz

Aim: The
studies conducted to investigate the association between biochemical
manifestations of hyperparathyroidism such as serum parathyroid hormone, serum
calcium, and serum phosphate levels, and parathyroid adenoma weight and volume
have conflicting results. We aimed to investigate whether there is an association
of preoperative size of adenoma with laboratory parameters and cardio-metabolic
risk factors in patients with primary hyperparathyroidism.

Material and Method: Seventy-five patients with PHPT and 96 control
subjects were enrolled in the study. Demographic, anthropometric and
biochemistry data were recorded. Correlation analysis was used for determining
the relation between adenoma volume and cardio-metabolic parameters.
Preoperative adenoma volume was calculated by
the ellipsoid model formula.

Results: Mean age
was similar between groups (52.69 ± 10.91 to 53.33 ± 7.70, p:0.667). Mean size
of adenoma was 1.42 ± 2.62
cm³. Size of adenoma was positively correlated with calcium and
parathormone levels and negatively correlated with vitamin D level (p<0.05).
Size of adenoma was not correlated with cardio-metabolic risk factors including
systolic
blood pressure, diastolic blood pressure, age, fasting plasma glucose, lipid
profile, body mass index, carotis intima media thickness, CRP and HOMA-IR
(p>0.05). PTH, calcium, phosphorus or vitamin D levels were also not
correlated cardio-metabolic risk factors.

Conclusions: Adenoma
volume has a correlation with parathormone, calcium, phosphorus and vitamin D
levels, however, it is not associated with cardio-metabolic risk factors.

Anahtar Kelimeler

Primary hyperparathyroidism, adenoma volume, cardio-metabolic risk factors

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