Sodium-glucose co-transporter-2 inhibitors in Type 2 diabetes treatment

Yıl 2018, Cilt: 10 Sayı: 3, 381 - 385, 30.09.2018

İrfan Karahan , Çağar Alp , Aşkın Güngüneş

https://doi.org/10.21601/ortadogutipdergisi.333690

Öz

Sodium-glucose
co-transporter 2 (SGLT-2) inhibitors are new agents which are used in diabetes
treatment. Mechanism of action is inhibiting of glucose reabsorbation and
increasing of urinary glucose excretion from renal proximal tubules. These
agents could improve blood pressure and weight gain disorders. Many studies
showed some of these agents’ benefits on cardiovascular system. Main adverse
effects are infections. Drug management and adverse effects were reviewed in
this text.

Anahtar Kelimeler

SGLT-2 inhibitors, type 2 diabetes

Tip 2 diyabet tedavisinde sodyum-glukoz ko-transporter 2 inhibitörleri

Öz

Sodyum-glukoz
ko-transporter 2 (SGLT-2)
inhibitörleri, diyabet tedavisinde yeni kullanmaya başlanılan ajanlardır. Temel
etki mekanizması proksimal renal tübülden glukoz reabsorbsiyonunu engelleyerek
üriner glukoz ekskresyonunu arttırmaktır. Kan basıncı ve vücut ağırlığı üzerine
olumlu etkileri gösterilmiştir. Bunun dışında bazı çalışmalarda kardiyovasküler
faydaları da olabileceği gösterilmiştir. Başlıca yan etkileri enfeksiyonlar
olup diğer yan etkiler ve ilaç yönetimi bu yazıda tartışılmıştır. 

Anahtar Kelimeler

SGLT-2 inhibitörleri, tip 2 diyabet

Kaynakça

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