Persistent rubella IgM antibody during pregnancy: a case report

Yıl 2018, Cilt: 10 Sayı: 3, 391 - 393, 30.09.2018

Hatice Kansu Çelik , Sinem Eldem Esra Yaşar Çelik Burcu Kısa Karakaya Serpil Ünlü Yasemin Taşcı Yaprak Engin Üstün

https://doi.org/10.21601/ortadogutipdergisi.333714

Öz

A 28 years old, 19 weeks pregnant
woman ( gravida 3, parity 2, alive 2) admitted to our hospital from outpatient
clinic with positive antirubella IgM and IgG results. In our hospital Rubella
IgG avidity test was high (88%). Two years ago at her previous pregnancy,
antirubella IgM and IgG antibodies had been found to be positive. Fetal anomaly
screening ultrasound at 21th week of pregnancy had no classical finding of
congenital rubella syndrome. Pregnancy termination was not recommended and
she delivered a healthy baby.

Anahtar Kelimeler

Rubella virus, pregnancy, rubella IgM antibody, persistant

Gebelik sırasında persiste rubella IgM antikorları: olgu sunumu

Öz

28 yaşında, gravida 3, parite 2,
yaşayan 2, 19 hafta gebe olan hasta dış merkez tarafından kliniğimize pozitif antirubella
IgM ve IgG sonuçları nedeniyle yönlendilirdi. Hastanemizde Rubella IgG avidite
testi yüksek (%88 ) saptandı. 2 sene önceki gebelik döneminde yapılan Rubella
IgM ve IgG antikorları da pozitif gelen hastanın sonuçları  eski enfeksiyon lehine yorumlandı.  21. hafta fetal anomali ultrason taramasında
konjenital rubella sendromuyla ilgili bulgu saptanmadı. Hastaya gebelik
terminasyonu önerilmedi ve hasta sağlıklı bir bebek doğurdu.

Anahtar Kelimeler

Rubella virüsü, gebelik, rubella IgM antikor, persiste

Kaynakça

• 1-Gilbert GL, Rubella. In: Gilbert GL, editor. Infectious disease in pregnancy and the newborn infant. 2nd ed. Switzerland: Harwood Academic Publishers; 1997. p. 23-62.
• 2-Best JM, O’Shea S, Tipples G, et al. Interpretation of rubella serology in pregnancy-pitfalls and problems. BMJ 2002; 325:147-8.
• 3- -Control and prevention of rubella: evaluation and management of suspected outbreaks, rubella in pregnant women, and surveillance for congenital rubella syndrome. MMWR Recomm Rep 2001; 50: 1-23.
• 4-Vauloup-Fellous C, Grangeot-Keros L. Humoral immune response after primary rubella virus infection and after vaccination.lin Vaccine Immunol 2007; 14: 644-7. 5- Laboratory diagnosis of rubella infections. Available from: Congenital infections slide set: http://virology-online.com/viruses/Rubella 5.htm
• 6-Morgan-Capner P, Miller E, Vurdien JE, Ramsay ME. Outcome of pregnancy after maternal re-infection with rubella. Commun Dis Rep CDR Rev 1991; 1: 57-9 7- Best JM, Enders GM.2007. Laboratory diagnosis of rubella and congenital rubella. In: Banatvala JE, Peckham C. (Eds.). Rubella viruses. Perspectives in Medical Virology, 15, first ed. Elsevier Life Sciences. London. Pp. 39-77 5- Hudson P, Morgan-Capner P. Evaluation of 15 commercial enzyme immunoassays for the detection of rubella-specific IgM. Clin Diagn Virol. 1996;5:21-6 8-Morgan-Capner P. Measles, mumps and rubella viruses. Infectious Diseases 2nd ed. 2004. p.1986-88 9- Wandinger KP, Saschenbrecker S, Steinhagen K, Scheper T, Meyer W, Bartelt U, et al. Diagnosis of recent primary rubella virus infections: significance of glycoprotein-based IgM serology, IgG avidity and immunoblot analysis. J Virol Methods. 2011;174(1-2):85-93