Evaluation of hematological parameters in cases with premature adrenarche

Yıl 2018, Cilt: 10 Sayı: 3, 268 - 273, 30.09.2018

Nurullah Çelik , Emine Çamtosun , İsmail Dündar

https://doi.org/10.21601/ortadogutipdergisi.429250

Öz

Aim: To investigate hematological parameters in cases with non-obese
premature adrenarche (PA) and to evaluate the correlations between this
parameters and androgen levels

Material and Method: The study was a case-control study and the files of
the patients was analysed retrospectively. Forty-four children with PA aged 6-9
years and their age and sex matched healthy controls (n=45) were included for
the study. Hematological parameters between groups were compared and the
correlations between this parameters and androgen levels were evaluated.

Results: The mean ages of the case (7.61±1) and control (7.42±0.9) groups were
similar (p>0.05). When we compared between case and control groups, mean
erythrocyte count (5.07±0.22, 4.87±0.31; p<0.05), hemoglobin (Hgb) levels
(13.77±0.79, 12.89±0.84; p<0.05), mean corpuscular volume (81.83±3.73,
79.99±3.74; p<0.05) and red cell distribution wide (12.71±1.80, 13.56±0.66;
p<0.05) were different. On the other hand, dehydroepiandrosterone sulfate
level was positively correlated with Hgb levels (r=0.27; p=0.03).

Conclusion: Higher Hgb and erythrocyte levels in cases
with PA may be partially
explained with increased early and accelerated function in the androgen
biosynthetic steps in this patients. Larger comprehensive studies with an increased
number of cases in each group are needed to explore the alterations. early and
accelerated function in the androgen biosynthetic steps.

Anahtar Kelimeler

Premature adrenarche, erythrocyte, hemoglobin, dehydroepiandrosterone sulfate

Prematür adrenarşli olgularda hematolojik parametrelerin değerlendirilmesi

Öz

Amaç: Obez olmayan prematür adrenarşlı olgularda hematolojik parametreleri
değerlendirmek ve bu parametrelerin androjenlerle olan korelasyonlarını
göstermektir.

Gereç ve Yöntem: Bu çalışma bir vaka kontrol çalışması olup hasta
dosyaları retrospektif olarak araştırıldı. PA tanılı 6-9 yaş arası prepubertal
44 çocuk ile herhangi
bir sistemik hastalığı olmayan yaş ve
cinsiyetleri benzer 45 çocuk çalışmaya dahil edildi. Gruplar arası hemogram
parametreleri karşılaştırıldı, androjen düzeyleri ile olan korelasyonları
değerlendirildi.

Bulgular:  Vaka grubunda yaş ortalaması
7,61±1 yıl iken kontrol grubunda 7,42±0,9 idi, (p>0,05). Vaka ve kontrol
grubu karşılaştırıldığında eritrosit sayıları (5,07±0,22, 4,87±0,31;
p<0,05), Hemoglobin düzeyleri (Hgb) (13,77±0,79, 12,89±0,84; p<0,05),
ortalama eritrosit hacmi (81,83±3,73, 79,99±3,74; p<0,05) ve eritrosit
dağılım aralığı (12,71±1,80, 13,56±0,66; p<0,05) farklı idi. Ayrıca
dehidroepiandrosteron-sülfat düzeyi ile Hgb düzeyi arasında pozitif bir
korelasyon vardı (r=0,27; p=0,03).

Sonuç: Prematür
adrenarşlı olgularda
daha yüksek Hgb ve eritrosit düzeyleri bu olgularda görülen androjen biyosentez basamaklarında erken hızlanmış fonksiyonel aktivite
ile ilişkili olabilir. Bu konuda daha geniş vaka serili çalışmalara ihtiyaç
vardır. 

Anahtar Kelimeler

Prematür adrenarş, hemoglobin, eritrosit, dehidroepiandrosteron sülfat

Kaynakça

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