Effect of H1 and H2 receptor antagonists on blood gas

Yıl 2018, Cilt: 10 Sayı: 3, 279 - 283, 30.09.2018

Selma Karaahmetoğlu , Yavuz Erkoçak

https://doi.org/10.21601/ortadogutipdergisi.441553

Öz

Aim: Histamine is a common anhydrous
substance in the organism. Histamine responses of the cells were found in the
cytoplasm of H1 and it is provided by H2 receptors. In the IBU study, it was
aimed to investigate the effect of drug-blocking of histamine receptors
commonly found in organism on blood gas, which is maintained in a very narrow
range with kidney lung and hemoglobin.

Material and
Method: Between
1988-1989, 25 female and 20 male patients who were hospitalized in Ankara
Numune Hospital 1st Internal Medicine Clinic were included in this study. H1
and peptic ulcer patients received H2 receptor antagonists intravenously at the
usual treatment dose and blood gas samples were taken before and 1 hour after
administration. Blood gas evaluation was performed in the control group at 1
hour interval without drug administration.

Result: The change of pH, pO₂,
HCO₃, BEB, BEcf of H1 receptor antagonists was statistically
insignificant (p>0.05) while pCO₂ value was statistically
significant (36.01+4.023 before treatment, 34.42+3.72 p<0.05 after
treatment). H2 receptor antagonist administration showed statistically
insignificant change in pCO₂ and pO₂ levels but
statistically significant increase in pH (<0.05), HCO₃ (p<0.001),
BEB (p<0.01) and BEcf (p<0.01).

Conclusion: Histamine receptor antagonist
drugs may cause changes to the blood gas parameters that are not pathological
depending on the receptors to which they are antagonized. However, there is a
need for more extensive work to comment on whether or not they will cause
serious problems in clinical situations that cause change in blood gas.

 

Anahtar Kelimeler

H1 and H2 receptor antagonist, blood gas, effect

H1 ve H2 reseptör antagonistlerinin kan gazı üzerine etkisi

Öz

Amaç: Histamin organizmada yaygın
olarak bulunan bir amindir. Hücrelerin histamine yanıtları sitoplazmada bulunan
H1 ve H2 reseptörleri ile sağlanır. Bu çalışmada organizmada yaygın
olarak bulunan histamin reseptörlerinin ilaçlarla bloke edilmesinin böbrek
akciğer ve hemoglobin aracılığı ile çok dar aralıkta dengede tutulan kan gazı
üzerine etkisinin araştırılması amaçlanmıştır.

Gereç ve Yöntem: Çalışma 1988-1989 yılları
arasında Ankara Numune Hastanesi 1. Dahiliye Kliniği’ne yatarak tedavi gören 25
peptik ülser, 10 alerji, 10 kan gazını etkilemeyen farklı hastalık nedeniyle
yatan 25 kadın 20 erkek olgu alındı. Alerji nedeniyle yatan hastalara H1 ve
peptik ülser hastalarına H2 reseptör antagonistleri olağan tedavi dozunda intravenöz
uygulandı. Uygulamadan önce ve uygulamadan 1 saat sonra kan gazı örnekleri
alınarak değerlendirme yapıldı. Kontrol grubuna ilaç verilmeksizin 1 saat ara
ile kan gazı değerlendirmesi yapıldı.

Bulgular: H1 reseptör antagonistlerinin pH,
pO₂,  HCO₃, BEB,
BEcf değişimi istatistiksel olarak anlamsız bulunurken (p>0.05), pCO₂
değerinde ise istatisksel olarak anlamlı düşme (ilaç öncesi 36,01+4,023; ilaç
sonrası ortalama pCO₂ 34,42+3,72 p<0.05) saptandı. H2 reseptör
antagonisti uygulamasında ise pCO₂ ve pO₂ değişiminde
istatistiksel olarak anlamlı değişiklik bulunmazken, pH (<0.05), HCO₃
(p<0.001), BEB (p<0.01) ve BEecf  (p<0.01)
değerlerinde istatistiksel olarak anlamlı artma bulundu

Sonuç: Histamin reseptör antagonisti
ilaçlar kan gazı parametrelerinde antagonize ettikleri  reseptörlere bağlı olarak patolojik
sınırlarda olmayan değişimlere neden olabilirler. Ancak kan gazında değişime
neden olan klinik durumlarda ciddi problem yaratıp yaratmayacakları hakkında
yorum yapabilmek için daha kapsamlı çalışmalara gereksinim vardır.

Anahtar Kelimeler

H1 ve H2 reseptör antagonisti, kan gazı, etki

Kaynakça

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