The relationship between vitamin D levels and 24-hour ambulatory blood pressure in renal transplantation patients

Yıl 2018, Cilt: 10 Sayı: 3, 302 - 306, 30.09.2018

Fatih Karaahmet , Mustafa Arıcı

https://doi.org/10.21601/ortadogutipdergisi.449335

Öz

Aim: Renal transplantation is the most prominent treatment of renal insufficiency. Vitamin D deficiency found to be common in renal transplant patients. Through renin-angiotensin-aldosterone system inhibition, it protects from hypertension and cardiovascular diseases. In this study, we investigated the relation between vitamin D levels and 24-hour ambulatory blood pressure monitoring and parameters (body mass index, fasting plasma glucose, lipid profile) that may affect graft function.

Material and Method: Association of clinical parameters with vitamin D levels and blood pressure were prospectively compared in renal transplant patients. All patients blood pressure levels were evaluated by 24-hour ambulatory blood pressure monitoring.

Results: A total of 115 renal transplant recipients were enrolled in the study. Mean level of vitamin D was 16.28±5.2ng/ml, 10.4 % of the patients had severe vitamin D insufficiency (<10ng/ml), 70.4 % with a level between 10-20ng/ml. The vitamin D deficiency (10-20ng/ml) was seen more frequently in women than man. Patients has been divided into two groups, the first with levels of less than 20 ng/ml, the second one with levels of equal or higher than 20 ng/ml. There were no statistically significant difference in age, body mass index and donor features between two groups. Systolic, diastolic, and mean artery 24-hour ambulatory blood pressures in two groups were similar.

 Conclusion: Vitamin D deficiency was found to be common in renal transplant patients. Vitamin D status was not found to be associated with blood pressure in renal transplant patient.

Anahtar Kelimeler

Hypertension, vitamin D levels, renal transplantation, 24-hour ambulatory blood pressure, graft function

Böbrek nakli hastalarında vitamin D düzeyi ve 24 saatlik ambulatuar kan basıncı ilişkisi

Öz

Amaç:
Böbrek transplantasyonu böbrek yetmezliğinin en önde tedavisidir. Renal
transplant hastalarında D vitamini eksikliği yaygın görülmektedir. Vitamin D
Renin-anjiyotensin-aldosteron sistemi inhibisyonu ile hipertansiyon  ve kardiyovasküler hastalıklardan
korumaktadır. Bu çalışmadaki amaç, vitamin D düzeyleri ile 24 saatlik
ambulatuar kan basıncı ve greft fonksiyonunu etkileyebilecek parametreler
(vücut kitle indeksi, açlık plazma glikozu, lipit profili) arasındaki ilişkiyi
belirlemektir.

Yöntem
ve Gereç: Renal transplant hastalarında klinik
parametreler, D vitamini düzeyleri ve kan basıncı arasındaki ilişki
karşılaştırıldı. Tüm hastaların kan basıncı seviyeleri 24 saatlik ambulatuar
kan basıncı takibi ile değerlendirildi.

Bulgular:
Çalışmaya toplam 115 renal transplant hastası alındı. Ortalama D vitamini
düzeyi 16,28 ± 5,2ng/ml olup hastaların % 10,4'ünde ciddi vitamin D yetmezliği
(<10ng / ml), ve % 70,4'ünde vitamin D eksikliği (10-20ng/ml) saptandı. D
vitamini eksikliği (10-20ng/ml) kadınlarda erkeklerden daha sık olduğu bulundu.
Çalışmada hastalar iki gruba ayrıldı, birinci gurup vitamin D düzeyi 20
ng/ml'den az olanlar, ikinci gurup vitamin D düzeyi 20 ng/ml'ye eşit ya da daha
yüksek olanlar. İki grup arasında yaş, vücut kitle indeksi ve donör
özelliklerinde istatistiksel olarak anlamlı fark yoktu. Sistolik, diyastolik ve
ortalama 24 saatlik ambulatuar kan basıncı her iki grupta benzerdi.

Sonuç:
D vitamini eksikliği renal transplant hastalarında yaygın olduğu saptandı.
Renal transplant hastalarında vitamin D düzeyinin kan basıncı ile ilişkili
olmadığı bulundu.

Anahtar Kelimeler

Hipertansiyon, vitamin D, böbrek nakli, 24 saatlik ambulatuvar kan basıncı, greft fonksiyonu

Kaynakça

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