Treatment results of chronic delta hepatitis patients

Yıl 2019, Cilt: 11 Sayı: 1, 73 - 77, 31.03.2019

Celal Ayaz , Tuğba Sarı

https://doi.org/10.21601/ortadogutipdergisi.494395

Öz

Aim: Chronic
delta hepatitis has been reported in 2,3-2,7% of studies in our country.
Chronic delta hepatitis cases progress rapidly and show poor prognosis and the
rate of developing cirrhosis are 70% in 5-10 years. The success of interferon
(IFN) based treatment regimens for the treatment of delta hepatitis is about
30%. However, there is frequent relapse at the end of therapy, unless HBsAg
seroconversion is developed.

Material and Methods:
In this study, patients with chronic Delta hepatitis were evaluated
retrospectively and the patients who were treated successfully were reviewed by
reviewing the literature. Anti-HDV was positive in 243 (4.44%) of 5471 HBsAg
positive patients who applied between 2012-2017. Peg-IFN alpha 2a was given if
dominated by HDV and Peg-IFN alpha 2a and tenofovir
disoproksil were given if dominant by HBV.

Results:
The patients who were treated were evaluated and at the end of the treatment 10
of the patients had HBs Ag seroconversion and anti-HBs were positive.

Conclusion: Effective
and timely treatment of chronic hepatic hepatitis cases will prevent the
complications related to liver failure and prevent death.

Anahtar Kelimeler

delta hepatitis, hepatitis B, treatment

Kronik delta hepatitli hastalarımızın tedavi sonuçları

Öz

Amaç: Kronik
delta hepatiti ülkemizde yapılan çalışmalarda %2,3-2,7 oranında
bildirilmektedir. Kronik Delta hepatitli olgular hızlı ilerleyerek ve kötü prognoz
gösterir ve 5-10 yıl içinde %70 oranında siroz gelişir. Delta hepatiti
tedavisinde interferon (IFN) temelli tedavi rejimlerinin başarısı %30 civarındadır.
Ancak tedaviyi sonlandırdıktan sonra HBsAg serokonversiyonu gelişmediği sürece
sık relaps görülmektedir. Bu çalışmada kronik Delta hepatitli olgular
retrospektif olarak incelenmiş ve tedavi başarısı sağlanan hastalar
tartışılmıştır.

Gereç ve Yöntemler:
2012-2017 tarihleri arasında başvuran 5471 HBsAg pozitif hastanın 243’ünde (%4,44)
Anti-HDV pozitifliği saptandı. Hastalara HDV dominant virüs ise Peg-IFN alfa
2a, HBV enfeksiyonu dominant ise Peg-IFN alfa 2a ve tenofovir
disoproksil kombinasyonu verildi.

Bulgular:
Tedavi verilen hastalar değerlendirildiğinde, tedavi sonrası 10’unda (%4,11)
HBs Ag serokonversiyonu geliştiği ve Anti-HBs’nin pozitifleştiği görüldü.

Sonuç:
kronik Delta hepatit olgularında etkili ve zamanında tedavi sağlanması ile
karaciğer yetmezliğine bağlı komplikasyonları önleyebilir.

Anahtar Kelimeler

delta hepatit, hepatit B, tedavi

Kaynakça

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