Sağlık Çalışanlarında ve Poliklinik Hastalarında H1N1 IgG Antikor Sıklığının Karşılaştırılması

Yıl 2016, Cilt: 8 Sayı: 1, 7 - 11, 01.03.2016

Salih Cesur Hasan Irmak Aydın Çifci Sami Kınıklı Ali Pekcan Demiröz Zeynep Bıyıklı Gençtürk

Öz

Amaç: Pandemik influenza döneminde sağlık çalışanlarında H1N1 influenza virüsü IgG antikor sıklığının H1N1 döneminde üst solunum yolu semptomları ile müracat eden ve olası pandemik H1N1 enfeksiyonu olan poliklinik hastaları ile karşılaştırılması idi.Gereç ve Yöntemler: Çalışmaya 53 sağlık personeli [ 15 doktor , 16 hemşire , 22 yardımcı sağlık personeli ile 29 poliklinik hastası olmak üzere influenza A H1N1 aşısı uygulanmamış 82 kişi dahil edildi. Sağlık çalışanlarında ve poliklinik hastalarında influenzaya yönelik semptomların varlığı sorgulandı. Sağlık personeli ve hasta grubunda H1N1 IgG antikor düzeyleri ELISA yöntemiyle belirlendi. İstatistiksel analizler SPSS programında yapıldı. p

Anahtar Kelimeler

Sağlık çalışanları, poliklinik hastaları, H1N1, seroprevalans, IgG, ELISA

Evaluation of The Seroprevalence of H1N1 IgG Antibodies Between Healthcare Workers and Outpatients

Öz

Aim: The aim of the present study was to compare the seroprevalence of pandemic H1N1 IgG antibodies between health care workers and patients presenting with upper airway symptoms suggestive of H1N1 influenza infection who are admitted to the outpatient clinics during pandemic H1N1 influenza infection.Material and Methods: The present study comprised 82 subjects unvaccinated with influenza A H1N1 vaccination, including 53 health care workers 33 females, 20 males, 15 doctors; median age: 38 years , 16 nurses median age: 26.5 years , 22 auxiliary health care workers median age: 32 years , and 29 outpatients 14 females, 15 males; median age: 38 years . The presence of symptoms suggestive of pandemic influenza infection was questioned in the health care providers and outpatients. Serum H1N1 IgG antibody levels were determined in the health care workers and outpatients using the ELISA method. The statistical analyses were performed using the SPSS software package. ANOVA analysis of variance was used to evaluate the significance of difference between the groups, and the Kruskal-Wallis test was used to evaluate the significance of difference in terms of median values. The nominal variables were analyzed using Pearson’s chi-square test or Fisher’s exact test. A p value of < 0.05 was considered statistically significant. Results: The seroprevalence of H1N1 IgG antibody positivity for health care workers and outpatients were %43.3 and %6.9, respectively. H1N1 IgG antibody seropositivity did not show a significant relation with gender and mean age p=0.87 and p=0.657, respectively . There was a statistically significant difference between health care workers and outpatients in terms of H1N1 IgG antibody seropositivity p

Anahtar Kelimeler

Healht care workers, outpatients, H1N1, seroprevalance, IgG, ELISA

Kaynakça

• Aktas F. H1N1 Vaccine: To vaccinate or not? ANKEM Journal 2010; 24: 201 - 205.
• Tasova Y, Balkan II. H1N1: clinical presentation. ANKEM Journal 2010;24(Ek 2):196-200.
• Peiris JS, Poon LL, Guan Y. Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans, J Clin Virol 2009;45(3):169-73.
• Budak S, Acar A, Karacaer Z, Diktas H, Turhan V, Oncul O, Gorenek L.GATA Pandemic influenza A / H1N1 vaccination and vaccine-related side effects of Haydarpasa Training Hospital healthcare workers. Turkish Hygiene and Experimental Biology Journal 2011; 68(4): 185 – 190.
• Ormen B, Turker N, Vardar I, et al. Opinions About Immunization and Observed Side Effects After Pandemic Influenza A (H1N1) Vaccine Application on Hospital Staff. Microbiol Finding. 2012 ;46(1):57-64.
• Gurbuz Y, Tutuncu ED, Sencan I, Sendag E, Callak F, Sevinc G, Tekin A. Investigation on approach of the hospital staff to Influenza A (H1N1) vaccine in the 2009 pandemic. Pamukkale Medical Journal 2013;6(1):12-17.
• General Directorate of Health Services 2009 Data ) http://www. saglik.gov.tr/TR/belge/1-2952/istatistik-yilliklari.html Directorate of Health Services 2009 Data 8. Company catalog http: // www.sekisuivirotech.com. (Turkish) General