Comparison of Clinical Features and Treatment Outcomes of Young and Older Adult Patients with Primary İmmune Thrombocytopenia

Öz

In this study, we aimed to investigate the discrepancies regarding the clinical characteristics and the treatment outcomes between immune thrombocytopenic purpura patients ≤ 60 y and > 60 y, which is the cut-off age for the definition of old age by the WHO. We retrospectively analyzed the data of 67 immune thrombocytopenic purpura patients diagnosed and treated in the Hematology clinic between December 2014 and February 2019. The median age of the patients was 44 years (range, 17-86); 48 (71.6%) patients were female and 19 (28.4%) were male. There were 50 (74.6%) patients aged ≤ 60 y and 17 (25.4%) patients > 60 y. When two groups were compared with respect to treatment features, they were similar in responding to the therapies, the loss of response to therapies and in duration of response to the therapies (p>0.05). When the cutoff point for age was 50 and 65 years again the groups were similar in terms of disease and treatment characteristics (p>0.05). Despite the clinical complexicity and heterogeneity of older adults, the treatment outcomes of olderimmune thrombocytopenic purpura patients seem to be similar to the young ones.

Anahtar Kelimeler

• ITP
• fragility
• treatment outcomes
• older adults

Primer İmmün Trombositopenili Genç ve Yaşlı Erişkin Hastaların Klinik Özelliklerinin ve Tedavi Sonuçlarının Karşılaştırılması

Öz

Bu çalışmada, DSÖ'nün yaşlılık tanımı için kesme yaşı olan 60 yaş ve üstü immun trombositopenik purpura hastaları arasında klinik özellikler ve tedavi sonuçları ile ilgili farklılıkları araştırmayı amaçladık. Yöntem: Aralık 2014 ile Şubat 2019 arasında Hematoloji kliniğinde teşhis ve tedavi edilen 67 immun trombositopenik purpura hastasının verilerini geriye dönük olarak analiz ettik. Hastaların ortanca yaşı 44 (aralık, 17-86); hastaların 48'i (%71,6) kadın, 19'u (%28,4) erkekti. ≤ 60 yaşında 50 (%74.6) hasta ve > 60 yaşında 17 (%25.4) hasta vardı. Tedavi özellikleri açısından iki grup karşılaştırıldığında, tedavilere yanıt verme, tedavilere yanıt kaybı ve tedavilere yanıt süresi açısından benzerdi (p>0.05). Yaş için kesme noktası 50 ve 65 olduğunda yine gruplar hastalık ve tedavi özellikleri açısından benzerdi (p>0.05). Yaşlı yetişkinlerin klinik karmaşıklığına ve heterojenliğine rağmen, yaşlı immun trombositopenik purpura hastalarının tedavi sonuçları gençlere benzer görünmektedir.

Anahtar Kelimeler

• ITP
• frajilite
• tedavi sonuçları
• yaşlı erişkinler

Kaynakça

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