The effect of initiation of antihypertensive medication on MPV level in newly diagnosed hypertensive patients

Öz

Platelet activation is a factor involved in the pathogenesis of hypertension. It also contributes to the development of thrombotic events and target organ damage due to hypertension. Mean platelet volume is an easily measurable parameter indicating platelet activation. To evaluate whether there is any change in MPV levels after starting antihypertensive medication in newly diagnosed hypertensive patients. 79 patients who were started on antihypertensive medication were evaluated retrospectively. 24.1% of the patients had microalbuminuria. MPV values before and after (5.8±3.6 months) the start of the antihypertensive drug were compared statistically. A statistically significant decrease in mean MPV value was found after starting antihypertenive medication (8.92±1.76 fL vs. 8.38±1.60 fL, p<0.001). The mean MPV value was higher in the microalbuminuric group than in the normoalbuminuric group (9.24±1.10 fL vs. 8.49±1.75 fL, p=0.028). A significant decrease in mean MPV level was detected in the first year following the initiation of antihypertensive medication in newly diagnosed hypertensive patients.

Anahtar Kelimeler

• hypertension
• mean platelet volume
• microalbuminuria

Yeni tanı konulan hipertansif hastalarda antihipertansif ilaç başlanmasının MPV düzeyine etkisi

Öz

Trombosit aktivasyonu hipertansiyon patogenezinde rol oynayan bir faktördür. Ayrıca, trombotik olayların gelişimine ve hipertansiyona bağlı hedef organ hasarına katkıda bulunur. Mean platelet volume, platelet aktivasyonunu gösteren kolay ölçülebilir bir parametredir. Bu çalışmanın amacı, yeni tanı almış hipertansif hastalarda antihipertansif ilaç tedavisine başlandıktan sonra MPV düzeylerinde herhangi bir değişiklik olup olmadığını değerlendirmektir. Antihipertansif ilaç tedavisine başlanan 79 hasta retrospektif olarak değerlendirildi. Hastaların% 24.1'inde mikroalbüminüri vardı. Antihipertansif ilacın başlamasından önceki ve sonraki MPV değerleri (5.8=3.6 ay) istatistiksel olarak karşılaştırıldı. Antihipertansif ilaç tedavisine başlandıktan sonra ortalama MPV değerinde istatistiksel olarak anlamlı azalma saptandı (8.92=1.76 fl'ye karşılık 8.38=1.60 fL, p<0.001). Ortalama MPV değeri mikroalbüminürik grupta normoalbüminürik gruba göre daha yüksekti (9.24=1.10 fLvs. 8.49 = 1.75 fL, p = 0.028). Yeni tanı konulan hipertansif hastalarda antihipertansif ilaç başlanmasını takip eden ilk yıl içinde ortalama MPV düzeyinde anlamlı bir azalma tespit edildi.

Anahtar Kelimeler

• hipertansiyon
• mean platelet volum
• mikroalbuminuri

Kaynakça

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