Long-Term Effects of Positive Airway Pressure Treatment on Restless Legs Syndrome Severity in Obstructive Sleep Apnea Syndrome

Öz

To research how long-term positive airway pressure (PAP) therapy affects the severity of restless legs syndrome in patients with obstructive sleep apnea syndrome (OSASThe study included 320 individuals that were diagnosed with moderate and severe OSAS using polysomnography (PSG) and under PAP treatment. Among these patients, the demographic data of 72 patients who met the diagnostic criteria of restless legs syndrome (RLS) were analyzed. The patients were evaluated with the International RLS Study Group rating scale (IRLS) before and at the 12th month after PAP in the treatment of OSAS. The mean body mass index of the 72 patients with OSAS and RLS was 31.2 (±5.8), and their mean apnea-hypopnea index was 44.9±27.7. The prevalence of RLS in moderate and severe OSAS was 24%. There was a negative correlation between the IRLS score and mean oxygen saturation all night (r: -0.075), minimum oxygen saturation all night (r: -0.125), time spent below <90% saturation (r: -0.172), and sleep efficiency (r: 0.087) on PSG performed before PAP treatment, as well as a negative correlation between the IRLS score and weekly PAP use hours at the 12th month after PAP treatment (r: -0.316; p<0.001). The data obtained from this study suggest that the coexistence of OSAS and RLS is common and should not be overlooked in the diagnosis of comorbid diseases. Long-term PAP treatment is effective in reducing RLS symptoms. Further studies are needed on this subject.

Anahtar Kelimeler

• Restless legs syndrome
• obstructive sleep apnea syndrome
• positive airway pressure treatment.

Obstrüktif Uyku Apne Sendromunda Pozitif Havayolu Basıncı Tedavisinin Huzursuz Bacak Sendromu Şiddeti Üzerindeki Uzun Dönem Etkileri

Öz

Obstrüktif uyku apne sendromunda (OUAS) pozitif hava yolu basıncı (PAP) tedavisinin huzursuz bacak sendromu şiddeti üzerindeki uzun vadeli etkilerini araştırmak. Çalışmaya polisomnografi (PSG) ile orta ve ağır OUAS tanısı konulan ve PAP tedavisi alan 320 kişi dahil edildi. Bu hastalardan huzursuz bacak sendromu (HBS) tanı kriterlerini karşılayan 72 hastanın demografik verileri analiz edildi. OUAS tedavisinde PAP öncesi ve sonrası 12. ayda hastalar Uluslararası HBS Çalışma Grubu Derecelendirme Ölçeği (IRLS) ile değerlendirildi. OUAS ve HBS olan 72 hastanın ortalama vücut kitle indeksi 31,2 (±5,8), ortalama apne-hipopne indeksi 44,9±27,7 idi. Orta ve şiddetli OUAS'ta HBS prevalansı %24 idi. IRLS skoru ile tüm gece ortalama oksijen satürasyonu (r: -0.075), tüm gece minimum oksijen satürasyonu (r: -0.125), <%90 satürasyonun altında geçirilen süre (r: -0.172) ve uyku arasında negatif korelasyon vardı. etkinliği (r: 0,087) ve PAP tedavisi sonrası 12. ayda IRLS skoru ile haftalık PAP kullanım saati arasında negatif korelasyon (r: -0,316; p<0,001) saptandı. Bu çalışmadan elde edilen veriler OUAS ve HBS birlikteliğinin yaygın olduğunu ve yandaş hastalıkların tanısında göz ardı edilmemesi gerektiğini düşündürmektedir. Uzun süreli PAP tedavisi HBS semptomlarını azaltmada etkilidir. Bu konuda ileri çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Huzursuz bacak sendromu
• obstrüktif uyku apne sendromu
• pozitif hava yolu basıncı tedavisi.

Kaynakça

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