Palmoplantar Dermatozlarda Lokal Psoralen-UVA Tedavisinin Etkinliği ve Güvenliği: Tek Merkezli Retrospektif Bir Çalışma

Öz

Lokal PUVA palmoplantar dermatozlarda dirençli vakalarda kullanılan tedavilerden biridir. Bu çalışmada palmoplantar dermatozların tedavisinde lokal PUVA'nın etkinliğini ve güvenilirliğini değerlendirmeyi amaçladık. Palmoplantar dermatoz (palmoplantar psoriasis, kontakt dermatit, palmoplantar keratoderma, dishidrotik ekzema) tanısıyla lokal PUVA ile tedavi edilen toplam 115 hasta çalışmaya dahil edildi. Ortalama maksimum doz 4.83 ± 2.55 ve ortalama kümülatif UVA dozu 171.30 ± 176.77 idi. Tedavi yanıtı değerlendirildiğinde 58 (%74.35) hastada tam yanıt, 15 (%19.23) hastada kısmi yanıt alınırken, 5 (%6.41) hastada yanıt alınamadı. Gruplar arasında cinsiyet, yaş dağılımı, hastalık süresi, ortalama tedavi süresi, seans sayısı ve tedaviye yanıt açısından hastalıklar arasında anlamlı fark yoktu. En sık görülen yan etki eritemdi ve hastaların 16'sında (%13.9) görüldü. Sonuç olarak lokal PUVA tedavisi palmoplantar dermatozlarda topikal steroid ve sistemik tedavi ihtiyacını azaltan etkili ve güvenli bir tedavi seçeneğidir.

Anahtar Kelimeler

• Fototerapi
• PUVA
• psoriasis
• ekzema

Efficacy and Safety of Local Psoralen-UVA Treatment in Palmoplantar Dermatoses: A Single-Center Retrospective Study

Öz

Local PUVA is one of the treatments used for resistant cases in palmoplantar dermatoses. In this study, we aimed to evaluate the efficacy and safety of local PUVA in the treatment of palmoplantar dermatoses. A total of 115 patients who were treated with local PUVA with the diagnosis of palmoplantar dermatosis (palmoplantar psoriasis, contact dermatitis, palmoplantar keratoderma, dyshidrotic eczema) were included in the study. The mean maximum single dose was 4.83 ± 2.55 and the mean cumulative UVA dose was 171.30 ± 176.77. Treatment response was evaluated in 78 (67.8%) of the patients; 37 (32.2%) patients were lost to follow up. When the treatment response was evaluated, 58 (74.35%) patients achieved a complete response; 15 (19.23%) patients achieved a partial response, and 5 (6.41%) patients had no response to the treatment. There was no significant difference between diseases in terms of gender and age distribution, disease duration, mean duration of treatment, number of sessions and response to treatment between groups. Erythema was the most common adverse effect and was observed in 16 (13.9%) of the patients. In conclusion, local PUVA treatment is an effective and safe treatment option in palmoplantar dermatoses that reduces the need for topical steroids and other systemic treatments.

Anahtar Kelimeler

• Phototherapy
• PUVA
• psoriasis
• eczema

Kaynakça

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