Association Between IFN-λ4 rs12979860 And rs11322783 Polymorphisms with Spontaneous Clearance In Chronic Hepatitis B

Öz

Many studies have been published on the association between IFN-λ3 and IFN-λ4 polymorphisms and treatment related or spontaneous clearance of chronic hepatitis C. To date there is little known about the impact of IFN-λ4 polymorphisms on the natural history of chronic hepatitis B(CHB). This study aimed to investigate the role of IFN-λ4 polymorphisms on the course of CHB and to influence the presence of spontaneous clearance (SC) in CHB patients. One hundred and twenty-two patients who had CHB, and 81 subjects who had spontaneous resolution of HBV were analyzed regarding IFN-λ4 rs12979860 and rs11322783 single‑nucleotide polymorphisms. We couldn’t found any significant difference between CHB groups and SC groups in terms of IFN-λ4 rs12979860 polymorphisms and, the CC, C/T and TT genotypes represented 49%, 45% and 5% of CHB patients and, %46, 43% and 11% of SC group respectively (p=0.65). On the other hand, in IFN-λ4 rs11322783 polymorphisms analysis, recessive G/G allele was more common in SC group compared to CHB group (5% vs 16%, p=0.04; OR: 3,55). Moreover, non-G/G genotypes had significantly higher in CHB patients compared to SC group (95% vs 84%, p=0.013; OR:3.55). Our results suggest that IFN-λ4 rs11322783 polymorphism may be a predictor of spontaneous clearance in HBV infected patients. The role of IFN-λ4 polymorphisms needs to be investigated in the natural history of HBV.

Anahtar Kelimeler

• Interferon-λ4
• Hepatitis B virus
• Single nucleotide polymorphism
• Spontaneous clearance

Kronik Hepatit B'de IFN-λ4 rs12979860 ve rs11322783 Polimorfizmlerinin Spontan Klirens ile İlişkisi

Öz

IFN-λ3 ve IFN-λ4 polimorfizmleri ile kronik hepatit C'nin tedaviye bağlı veya spontan klirensi arasındaki ilişki hakkında birçok çalışma yayınlanmıştır. Bugüne kadar IFN-λ4 polimorfizmlerinin kronik hepatit B'nin (KHB) doğal seyri üzerindeki etkisi hakkında çok az şey bilinmektedir. Bu çalışma, IFN-λ4 polimorfizmlerinin KHB'nin seyri üzerindeki rolünü ve KHB hastalarında spontan klirens (SK) mevcudiyeti üzerine etkisini araştırmayı amaçlamıştır. Yüz yirmi iki KHB hastası ve spontan HBV rezolüsyonu olan 81 birey IFN-λ4 rs12979860 ve rs11322783 tek nükleotid polimorfizmleri açısından analiz edilmiştir. IFN-λ4 rs12979860 polimorfizmleri açısından KHB ve SK grupları arasında anlamlı bir fark bulunamamış olup, CC, C/T ve TT genotipleri sırasıyla KHB hastalarının %49, %45 ve %5'ini, SK grubunun ise %46, %43 ve %11'ini temsil etmiştir (p=0.65). Öte yandan, IFN-λ4 rs11322783 polimorfizm analizinde, resesif G/G alleli KHB grubuna kıyasla SK grubunda daha sıktı (%5'e karşı %16, p=0,04; OR: 3,55). Ayrıca, G/G olmayan genotipler KHB hastalarında SK grubuna kıyasla anlamlı derecede daha yüksekti (%95'e karşı %84, p=0,013; OR:3,55). Sonuçlarımız, IFN-λ4 rs11322783 polimorfizminin HBV ile enfekte hastalarda spontan klirensin bir belirleyicisi olabileceğini düşündürmektedir. IFN-λ4 polimorfizmlerinin HBV'nin doğal seyrindeki rolünün araştırılması gerekmektedir.

Anahtar Kelimeler

• İnterferon-λ4
• Hepatit B virüsü
• Tek nükleotid polimorfizmi
• Spontan klirens

Kaynakça

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