Testis Kanserinde Hematolojik Parametrelerin Tani Yöntemleri İle Olan İlişkisi

Öz

Testis kanseri, genç yetişkin erkeklerde en sık görülen solid malignitedir. Bu çalışmanın amacı testis tümörlerindeki meydana gelen hematolojik parametrelerin, tanıda kullanılan geleneksel yöntemler ile ilişkisini araştırmaktadır. Testis tümörü nedeniyle radikal orşiektomi uygulanan 68 hasta retrospektif olarak incelendi. Hastaların yaş, başvuru şikayeti, tümör tarafı, radyolojik tümör boyutu, patolojik tümör boyutu, preoperatif tümör belirteçleri (AFP, β-hCG. LDH) kaydedildi. Ayrıca hastaların preoperatif hemogram parametrelerinden; WBC, nötrofil, lenfosit, monosit, bazofil, eozinofil, hemoglobin, platelet, ortalama korpüsküler hacim, ortalama trombosit hacmi, platelet dağılım genişliği değerleri kaydedildi. Ayrıca hemogram parametrelerinden elde edilen sistemik inflamatuvar belirteçler olan nötrofil lenfosit oranı, platelet lenfosit oranı, monosit lenfosit oranı, monosit platelet oranı, sistemik immün-inflamatuar indeks, sistemik inflamatuar response indeks, sistemik inflamatuar agregat indeks değerleri hesaplandı ve kaydedildi. Hematolojik parametreler incelendiğinde; lenfosit sayısı seminom grubunda 2,26±0,58 ×103/μL olarak saptanmış olup, non-seminom grubuna göre anlamlı yüksekti (p=0,020). WBC, MCV, MPV, PDW, nötrofil, monosit bazofil, eozinofil ve hemoglobin ve platelet değerleri her iki grupta benzerdi (hepsi p>0,05). NLR, PLR, SII değerleri non-seminom grubunda, MPR değeri ise seminom grubunda yüksek izlenmiştir (sırasıyla; p=0,03, p=0,004, p=0,01, p=0,04). Tam kan sayımından türetilen inflamasyon indeksleri ek tetkik gerektirmeyen maliyet düşük, güvenilir ve kolayca erişilebilir parametrelerdir. Bu indeksler ameliyat önce germ hücreli testis tümörlerinin histolojik alt gruplarını öngörme ve patolojik tanıyı destekleme amacıyla kullanılabilir.

Anahtar Kelimeler

• Testis tümörü
• Nötrofil
• Germ hücreli tümörler

Relationship Between Diagnostic Methods And Hematological Parameters In Testicular Cancer

Öz

Testicular cancer is the most common solid malignancy in young adult males. The aim of this study is to investigate the relationship between hematological parameters in testicular tumors and traditional methods used in diagnosis. Sixty-eight patients who underwent radical orchiectomy due to testicular tumor were retrospectively analyzed. Age, presenting complaint, tumor side, radiological tumor size, pathological tumor size, preoperative tumor markers (AFP, β-hCG, LDH) of the patients were recorded. In addition preoperative hemogram parameters of the patients; WBC, neutrophil, lymphocyte, monocyte, basophil, eosinophil, hemoglobin, platelet, mean corpuscular volume , mean platelet volume, platelet distribution width were recorded. In addition, systemic inflammatory markers obtained from hemogram parameters such as neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, monocyte-lymphocyte ratio, monocyte-platelet ratio, systemic immune-inflammatory index, systemic inflammatory response index, systemic inflammatory aggregate index were calculated and recorded. When hematological parameters were examined; lymphocyte count was determined as 2.26±0.58 ×103/μL in the seminoma group and was significantly higher than in the non-seminoma group (p=0.020). WBC, MCV, MPV, PDW, neutrophil, monocyte basophil, eosinophil and hemoglobin and platelet values were similar in both groups (all p>0.05). NLR, PLR, SII values were observed to be higher in the non-seminoma group and MPR value was observed to be higher in the seminoma group (p=0.03, p=0.004, p=0.01, p=0.04, respectively). Inflammation indices derived from complete blood count are low-cost, reliable and easily accessible parameters that do not require additional examination. These indices can be used to predict histological subgroups of germ cell testicular tumors before surgery and to support pathological diagnosis.

Anahtar Kelimeler

• Testicular Tumor
• Neutrophil
• Germ Cell Tumors

Kaynakça

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