Could the First Trimester Complete Blood Cell Indices Be Used to Predict Adverse Outcomes in Pregnant Women with Asthma?

Öz

The objective of this study was to investigate the efficacy of complete blood cell indices, specifically the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and systemic immune-response index (SIRI), in predicting composite adverse outcomes in pregnant women with asthma. This study employed a retrospective cohort design, enrolling 307 low-risk pregnant women and 97 pregnant women with asthma. The neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and systemic immune-response index (SIRI) were compared between pregnant women with asthma and the low-risk pregnancy group in the first trimester. A significant difference was observed in the first trimester SII between pregnant women with asthma and the low-risk pregnancy group (p=0.034). The neutrophil-to-lymphocyte ratio (NLR) and systemic immune response index (SIRI) demonstrated no significant differences between the groups. Moreover, pregnant women with asthma had significantly higher eosinophil count values as expected. The first trimester white blood cell count (WBC) and platelet count (PLT) were found to be significantly higher in the asthma group (p=0.014 and p=0.031, respectively). In the asthma group, no significant difference was found between the composite adverse pregnancy outcomes due to SII, SIRI, and NLR. Pregnant women with asthma exhibited significantly elevated values for SII, WBC, PLT and eosinophils. In our study, we observed no association between groups in complete blood cell indices due to the composite adverse effects of pregnancy. Further studies with larger groups are required to evaluate the efficacy of complete blood cell indices in pregnant women with asthma.

Anahtar Kelimeler

• Asthma
• pregnancy
• complete blood cell indices
• perinatology
• immune system

Astımlı gebe kadınlarda birinci trimester tam kan sayımı indeksleri olumsuz sonuçları tahmin etmek için kullanılabilir mi?

Öz

Bu çalışmanın amacı, astımlı gebelerde tam kan sayımı indekslerinin, özellikle nötrofil-lenfosit oranı (NLR), sistemik immün-inflamasyon indeksi (SII) ve sistemik immün-yanıt indeksinin (SIRI) bileşik olumsuz sonuçları öngörmedeki etkinliğini araştırmaktır. Bu çalışmada retrospektif bir kohort tasarımı kullanılmış ve 307 düşük riskli gebe ile 97 astımlı gebe çalışmaya dahil edilmiştir. Nötrofil-lenfosit oranı (NLR), sistemik immün-inflamasyon indeksi (SII) ve sistemik immün-yanıt indeksi (SIRI) ilk trimesterde astımlı gebeler ile düşük riskli gebelik grubu arasında karşılaştırıldı. Astımlı gebeler ile düşük riskli gebelik grubu arasında ilk trimester SII açısından anlamlı bir fark gözlendi (p=0.034). Nötrofil-lenfosit oranı (NLR) ve sistemik inflamasyon yanıt indeksi (SIRI) gruplar arasında anlamlı farklılık göstermedi. Ayrıca, astımlı gebelerde eozinofil sayısı beklendiği gibi anlamlı derecede yüksekti. İlk trimester beyaz küre sayısı (WBC) ve trombosit sayısı (PLT) astım grubunda anlamlı olarak daha yüksek bulunmuştur (sırasıyla p=0,014 ve p=0,031). Astım grubunda, SII, SIRI ve NLR'ye bağlı bileşik olumsuz gebelik sonuçları arasında anlamlı bir fark bulunmamıştır. Astımlı gebelerde SII, WBC, PLT ve eozinofil değerleri anlamlı derecede yüksek bulunmuştur. Çalışmamızda, gebeliğin bileşik yan etkilerine bağlı olarak tam kan hücresi indekslerinde gruplar arasında bir ilişki gözlenmemiştir. Astımlı gebelerde tam kan hücresi indekslerinin etkinliğini değerlendirmek için daha büyük gruplarla yapılacak ileri çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• Astım
• gebelik
• tam kan sayımı indeksleri
• perinatoloji
• immün sistem

Kaynakça

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