Kronik Venöz Yetmezlik Nedeniyle Endovenoz Lazer Ablasyon Uygulanan Hastalarda İnflamasyon ve Tromboz Risklerinin Araştırılması

Öz

Kronik venöz yetmezlik (KVY) sık görülen bir damar hastalığıdır ve endovenöz lazer ablasyon (EVLA) yaygın olarak kullanılan minimal invaziv bir tedavi yöntemidir. Bu çalışmada, EVLA uygulanan hastalarda perioperatif dönemde inflamatuvar ve trombotik belirteçlerdeki değişimlerin değerlendirilmesi amaçlandı Bu retrospektif çalışmaya, Ocak–Eylül 2025 tarihleri arasında Burdur Devlet Hastanesi’nde KVY nedeniyle EVLA uygulanan hastalar dahil edildi. Fibrinojen, D-dimer, C-reaktif protein (CRP), trombosit sayısı (PLT), ortalama trombosit hacmi (MPV), hemoglobin (Hb) ve hematokrit (Hct) düzeyleri preoperatif, postoperatif 1. gün ve 10. günde kaydedildi. İstatistiksel analizlerde eşleştirilmiş t-testi veya Wilcoxon işaretli sıralar testi kullanıldı. Çalışmaya toplam 24 hasta dahil edildi. Hastaların yaş ortalaması 48.4 ± 11.6 yıl olup (27–72), cinsiyet dağılımı %50 kadın (n=12) ve %50 erkek (n=12) şeklindeydi. D-dimer düzeyleri postoperatif 1. günde anlamlı olarak artarken (p<0,001), 10. günde azalma gösterdi (p<0,001). Fibrinojen düzeylerinde 1. günde anlamlı değişiklik izlenmezken, 10. günde anlamlı artış saptandı (p=0,018). CRP düzeyleri 1. günde yükseldi (p<0,001) ve 10. günde başlangıç değerlerine yaklaştı (p=0,107). MPV 1. günde azalırken (p=0,004), 10. günde artış gösterdi (p=0,047). PLT 1. günde azalmakla birlikte 10. günde normale döndü; Hb ve Hct değerlerinde ise geçici postoperatif düşüş izlendi. EVLA sonrası erken dönemde inflamatuvar ve trombotik belirteçlerde geçici değişiklikler meydana gelmekte olup, bu değişiklikler 10. gün itibarıyla büyük ölçüde normale dönmektedir. Bu bulgular EVLA’nın güvenilirliğini desteklemektedir.

Anahtar Kelimeler

• Kronik venöz yetmezlik
• endovenöz lazer ablasyon
• ortalama trombosit hacmi
• fibrinojen
• D-dimer
• inflamasyon
• tromboz

Evaluation of Inflammatory and Thrombotic Risk after Endovenous Laser Ablation in Patients with Chronic Venous Insufficiency

Öz

Chronic venous insufficiency (CVI) is a common vascular disorder, and endovenous laser ablation (EVLA) is a widely used minimally invasive treatment. This study aimed to evaluate perioperative changes in inflammatory and thrombotic markers following EVLA.This retrospective study included patients who underwent EVLA for CVI at Burdur State Hospital between January and September 2025. Fibrinogen, D-dimer, C-reactive protein (CRP), platelet count (PLT), mean platelet volume (MPV), hemoglobin (Hb), and hematocrit (Hct) were recorded preoperatively and on postoperative days 1 and 10. Statistical analyses were performed using paired t-tests or Wilcoxon signed-rank tests. A total of 24 patients were included in the study. The mean age was 48.4 ± 11.6 years (range: 27–72), with an equal distribution of females (n=12, 50%) and males (n=12, 50%). D-dimer levels increased significantly on postoperative day 1 (p <0.001) and decreased by day 10 (p <0.001). Fibrinogen levels showed no significant change on day 1 but increased by postoperative day 10 (p = 0.018). CRP levels increased on postoperative day 1 (p <0.001) and returned toward baseline by day 10 (p=0.107). MPV decreased on day 1 (p = 0.004) and increased by day 10 (p = 0.047). PLT declined on day 1 (p <0.001) and normalized by day 10, while Hb and Hct showed transient postoperative decreases. EVLA induces transient inflammatory and thrombotic changes that tend to normalize by postoperative day 10, supporting the overall safety of the procedure.

Anahtar Kelimeler

• Chronic venous insufficiency
• endovenous laser ablation
• mean platelet volume
• fibrinogen
• D-dimer
• inflammation
• thrombosis

Kaynakça

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