Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis

Emine Yağcı; Hasan Veysi Güneş

doi:10.20515/otd.287890

Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis

Öz

Notch sinyal yolağı, gelişim döneminde hücre kaderinin belirlenmesinde rol oynayan bir mekanizmadır. Notch reseptörü boyunca komşu hücreler arasındaki sinyal alışverişi artar. Notch aktivitesi organ oluşumu ve morfogenezde rol oynayarak farklılaşma, çoğalma ve apoptozu etkiler. Son çalışmalar Notch sinyalinin hücre farklılaşması ve proliferasyonu ile apoptotik olaylarda rol oynadığını kanıtlanmıştır. Ayrıca kanserli hücrelerde Notch aktivasyonunun anormal hücre çoğalmasına neden olduğu görülmüştür. Notch ile hücre çoğalması arasında önemli bir bağlantı olduğu birçok çalışmada gösterilmiştir. Bu derlemede Notch sinyal yolağı elementleri, aktivasyonu ve kanseri hangi mekanizmalarla etkilediği ele alınmaktadır.

Anahtar Kelimeler

Notch sinyal yolağı,Kanser,Apoptoz

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Derleme

Yazarlar

Emine Yağcı
ESKISEHIR OSMANGAZI UNIV
Türkiye

Hasan Veysi Güneş
ESKISEHIR OSMANGAZI UNIV
Türkiye

Yayımlanma Tarihi

15 Mart 2017

Gönderilme Tarihi

25 Ocak 2017

Kabul Tarihi

15 Mart 2017

Yayımlandığı Sayı

Yıl 2017 Cilt: 39 Sayı: 1

DOI

https://doi.org/10.20515/otd.287890

IZ

https://izlik.org/JA97SK63KD

Kaynak Göster

RIS / Bibtex

APA

Yağcı, E., & Güneş, H. V. (2017). Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis. Osmangazi Tıp Dergisi, 39(1), 109-116. https://doi.org/10.20515/otd.287890

AMA

1.Yağcı E, Güneş HV. Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis. Osmangazi Tıp Dergisi. 2017;39(1):109-116. doi:10.20515/otd.287890

Chicago

Yağcı, Emine, ve Hasan Veysi Güneş. 2017. “Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis”. Osmangazi Tıp Dergisi 39 (1): 109-16. https://doi.org/10.20515/otd.287890.

EndNote

Yağcı E, Güneş HV (01 Ocak 2017) Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis. Osmangazi Tıp Dergisi 39 1 109–116.

IEEE

[1]E. Yağcı ve H. V. Güneş, “Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis”, Osmangazi Tıp Dergisi, c. 39, sy 1, ss. 109–116, Oca. 2017, doi: 10.20515/otd.287890.

ISNAD

Yağcı, Emine - Güneş, Hasan Veysi. “Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis”. Osmangazi Tıp Dergisi 39/1 (01 Ocak 2017): 109-116. https://doi.org/10.20515/otd.287890.

JAMA

1.Yağcı E, Güneş HV. Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis. Osmangazi Tıp Dergisi. 2017;39:109–116.

MLA

Yağcı, Emine, ve Hasan Veysi Güneş. “Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis”. Osmangazi Tıp Dergisi, c. 39, sy 1, Ocak 2017, ss. 109-16, doi:10.20515/otd.287890.

Vancouver

1.Emine Yağcı, Hasan Veysi Güneş. Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis. Osmangazi Tıp Dergisi. 01 Ocak 2017;39(1):109-16. doi:10.20515/otd.287890