Comparison of Skin Prick Test Results Performed With Raw, Pasteurized and Commercial Cow’s Milk

Öz

Skin prick tests are the most commonly used method of diagnosing IgE-mediated reactions because of the high sensitivity and specificity of laboratory tests for allergic diseases, low cost and rapid response. Although many allergens have an extract to the commercial standard, skin prick tests made with standardized extracts are negative in a group of patients who describe reactions with foods, while positivity was determined by tests of the same foods with natural raw extracts. In this study, the reactions of raw, pasteurized and commercial extracts were compared in a skin prick test with children who applied with asthma, allergic rhinitis, atopic dermatitis and urticaria. Skin prick test was performed with raw, pasteurized and commercial extracts of the infected cow's cigarette with allergic disease in our policlinic. The files were reviewed retrospectively. Presenting symptoms, family history, and  laboratory findings were obtained from regular medical record. 245 female (49%) and 255 male (51%) children aged between 0 and 18 years were included in the study. The mean age was 6.28 ±4.31 years. Of the 500 patients, 46 (9.2%) had a positive skin prick test positive for raw milk. Skin prick test positivity was detected in 31 children (6.2%)  with  pasteurized milk and 20 children with commercial extracts.  There was no statistically significant difference between the prick test induration diameters of the children (p> 0.05). According to the pasteurized and commercial milk extracts, the skin prick tests performed with raw milk extracts showed more positivity and the positivity in the asthmatic patient group was found to be higher than the other patient groups.

Anahtar Kelimeler

• skin prick test; raw cow’s milk; pasteurized cow’s milk; commercial milk; allergic diseases

Çiğ, Pastörize ve Ticari İnek Sütü Deri Prik Testlerinin Karşılaştırılması

Öz

Birçok alerjenin ticari standardize ekstresi bulunmasına karşın, besinlerle reaksiyon tarifleyen bir grup hastada, standardize ekstrelerle yapılan deri prik testleri negatif iken, aynı besinlerin doğal çiğ ekstreleriyle yapılan testlerinde pozitiflik saptanmıştır. Bu çalışmada, astım, alerjik rinit, atopik dermatit ve ürtiker tanısı ile başvuran çocuklara inek sütü ile yapılan deri prik testinde çiğ, pastörize ve ticari ekstrelerin reaksiyonları karşılaştırılmıştır. Polikliniğimize alerjik hastalık öyküsüyle başvuran  hastalara inek sütünün çiğ, pastörize ve ticari ekstreleri ile deri prik testi yapıldı. Hastaların başvuru şikayetleri, aile öyküleri ve laboratuvar bulguları dosyalarından incelendi. Çalışmaya yaşları 0 ile 18 yaş arasında değişen 245 kız (%49), 255 erkek (%51) çocuk alındı. Ortalama yaş  6,284,31 yıl olarak saptandı. 500 hastanın, 46’sında   (%9,2) deri prik testinde çiğ süte karşı pozitiflik saptandı. 31 çocukta  (%6,2) pastörize süte,  20 çocukta (%4) standart ekstre  süte karşı pozitiflik saptandı.  Çocukların prik test endurasyon çapları arasında istatistiksel fark saptanmadı (p>0,05). Pastörize ve ticari süt ekstrelerine göre çiğ süt ekstreleriyle yapılan  deri prik testlerinde daha fazla pozitiflik saptanmış olup,  astımlı hasta grubundaki pozitiflik, diğer hasta gruplarına göre daha fazla bulunmuştur. 

Anahtar Kelimeler

• Deri prik test; çiğ inek sütü; pastörize inek sütü; ticari süt;

Kaynakça

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