The Effects of Increased Humidity and Weather Conditions on Inflammatory and Oxidative Stress Markers in Healthy Rats

Yıl 2020, , 75 - 80, 01.01.2020

Cuma Mertoğlu , Murat Günay , Vahdet Gül , Halis Süleyman Taha Abdulkadir Çoban

https://doi.org/10.20515/otd.463787

Öz

Although it is known that the
symptoms of rheumatoid arthritis patients increase in cold, humid and rainy
days but its mechanism is unclear. It was aimed to investigate the effects on
some inflammatory and oxidative stress markers in different weather conditions
in rats. Some inflammatory, oxidant and antioxidant markers were measured in
sera of healthy rats in sunny, cloudy and rainy days. The levels of reduced
glutathione (GSH) and glutathione reductase (GR) were found to be lower in both
cloudy and rainy days with respect to sunny days (p = 0.001 and 0.004
respectively). Similarly, α -glutathione-S-transferase levels were found to be
lower on rainy days than on sunny days (p = 0.017). Malondialdehyde (MDA) was
found to be higher (p = 0.044) in rainy days compared to sunny days.  Nitric oxide (NO) and interleukin-1β (IL-1β)
were found to be higher in cloudy and rainy days compared to sunny days (p =
0.003 and 0.025, respectively). The findings indicate that oxidative
stress-related inflammation is triggered in rainy and cloudy days. 

Anahtar Kelimeler

Inflammatory process. Bad weather condition. Oxidative stress. Chronic rheumatic disease

Nem ve Hava Koşullarının Subklinik İnflamasyon ve Oksidatif Stres Markırları Üzerine Etikileri

Öz

Romatoid artritli hastaların semptomlarının
soğuk, nemli ve yağmurlu günlerde arttığı bilinmekle birlikte, mekanizması açık
değildir. Bu çalışmada, farklı hava koşullarında, bazı inflamatuar ve oksidatif
stres markırlarının üzerine etkilerinin araştırılması hedeflenmiştir. Bazı
inflamatuar,  oksidan ve antioksidan
markırların düzeyleri,  güneşli, bulutlu
ve yağmurlu günlerde sağlıklı ratların serumunda ölçüldü. Glutatyon redüktaz
(GR) ve indirgenmiş glutatyon hem bulutlu hem de yağmurlu günlerde, güneşli
güne kıyasla daha düşük olarak bulundu (p = 0.001 ve 0.004 sırasıyla). α –
glutatyon-S-transferaz yağmurlu günde güneşli güne kıyasla daha düşük olduğu
bulundu (p = 0.017). Malondialdehit (MDA) yağmurlu günde güneşli güne kıyasla
daha yüksek olarak bulunmuştur (p = 0.044). Nitrik oksit ve interlökin-1 β
(IL-1β) bulutlu ve yağmurlu günde güneşli güne kıyasla daha yüksek bulunmuştur
(p = 0.003 ve 0.025, sırasıyla). Bulgular, yağmurlu ve bulutlu günlerde
oksidatif stres ilişkili inflamasyonun tetiklendiğini göstermektedir. 

Anahtar Kelimeler

İnflamatuar süreç; Kötü hava koşulları; Oksidatif stres; Kronik romatizmal hastalık.

Kaynakça

• 1. Timmermans EJ, Schaap LA, Herbolsheimer F, Dennison EM, Maggi S, Pedersen NL, Castell MV, Denkinger MD, Edwards MH, Limongi F, Sánchez-Martínez M, Siviero P, Queipo R, Peter R, Van Der Pas S, Deeg DJH. The influence of weather conditions on joint pain in older people with osteoarthritis: Results from the European project on osteoarthritis. J Rheumatol. 2015;42(10):1885–92. 2. Smedslund G, Hagen KB. Does rain really cause pain? A systematic review of the associations between weather factors and severity of pain in people with rheumatoid arthritis. Eur J Pain. 2011;15(1):5–10.3. Aikman H. The association between arthritis and the weather. Int J Biometeorol. 1997;40(4):192–9. 4. Guedj D, Weinberger A. Effect of weather conditions on rheumatic patients. Ann Rheum Dis. 1990;49(3):158–9. 5. Suleyman H, Cadirci E, Albayrak A, Halici Z, Polat B, Hacimuftuoglu A, Alp HH. Reason for the aggravation of diseases caused by inflammation and the ineffectiveness of NSAIDs on these diseases in rainy weather. Pharmacol Reports. 2009;61(3):514–9. 6. Tak PP, Zvaifler NJ, Firestein GS, Greene DR. Rheumatoid arthritis and p53: How oxidative stress, might alter the course of inflammatory diseases. Vol. 21, Immunology Today. 2000. p. 78–82. 7. Mateen S, Moin S, Khan AQ, Zafar A, Fatima N. Increased reactive oxygen species formation and oxidative stress in rheumatoid arthritis. PLoS One. 2016;11(4):1–15. 8. Smolen JS, Beaulieu A, Rubbert-roth A, Ramos-remus C, Rovensky J, Alecock E, Woodworth T, Alten R. Eff ect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis ( OPTION study ): a double-blind , placebo-controlled , randomised trial. Lancet. 2008;371:987–97. 9. Steiner G, Tohidast-Akrad M, Witzmann G, Vesely M, Studnicka-Benke A, Gal A, Kunaver M, Zenz P, Smolen JS. Cytokine production by synovial T cells in rheumatoid arthritis. Rheumatology (Oxford). 1999;38(3):202–13. 10. Nakachi S, Sumitomo S, Tsuchida Y, Tsuchiya H, Kono M, Kato R, Sakurai K, Hanata N, Nagafuchi Y, Tateishi S, Kanda H, Okamura T, Yamamoto K, Fujio K. Interleukin-10-producing LAG3 + regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis. Arthritis Res Ther. 2017;19. 11. Shoda H, Nagafuchi Y, Tsuchida Y, Sakurai K, Sumitomo S, Fujio K, Yamamoto K. Increased serum concentrations of IL-1 beta, IL-21 and Th17 cells in overweight patients with rheumatoid arthritis. Arthritis Res Ther. 2017;19(1):111. 12. Biswas SK. Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? Oxid Med Cell Longev. 2016;2016:17–9. 13. Hitchon CA, El-Gabalawy HS. Oxidation in rheumatoid arthritis. Arthritis Res Ther. 2004;6(6):265.14. Frei B. Reactive oxygen species and antioxidant vitamins: mechanisms of action. Am J Med. 1994;97(3A):5S–13S; discussion 22S–28S. 15. Baskol G, Demir H, Baskol M, Kilic E, Ates F, Karakukcu C, Ustdal M. Investigation of protein oxidation and lipid peroxidation in patients with rheumatoid arthritis. Cell Biochem Funct. 2006;24(4):307–11. 16. Kamanli a, Naziroglu M, Aydilek N, Hacievliyagil C. Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid arthritis. Cell Biochem Funct. 2004;22(January 2003):53–7. 17. El-barbary AM, Khalek MAA, Elsalawy AM, Hazaa SM. Assessment of lipid peroxidation and antioxidant status in rheumatoid arthritis and osteoarthritis patients. Egypt Rheumatol. 2011;33(4):179–85. 18. Mulherin DM, Thurnham DI, Situnayake RD. Glutathione reductase activity, riboflavin status, and disease activity in rheumatoid arthritis. Ann Rheum Dis. 1996;55(11):837–40. 19. Ali AM, Habeeb RA, El-Azizi NO, Khattab DA, Abo-Shady RA, Elkabarity RH. [Higher nitric oxide levels are associated with disease activity in Egyptian rheumatoid arthritis patients]. Rev Bras Reumatol. 2014;54(6):446–51. 20. Savage EM, McCormick D, McDonald S, Moore O, Stevenson M, Cairns AP. Does rheumatoid arthritis disease activity correlate with weather conditions? Rheumatol Int. 2015;35(5):887–90. 21. Abasolo L, Tobías A, Leon L, Carmona L, Fernandez-Rueda JL, Rodriguez AB, Fernandez-Gutierrez B, Jover JA. Weather conditions may worsen symptoms in rheumatoid arthritis patients: The possible effect of temperature. Reumatol Clínica (English Ed. 2013;9(4):226–8.22. Verges J, Montell E, Tomas E, Cumelles G, Castaneda G, Marti N, Moller I. Weather conditions can influence rheumatic diseases. Proc West Pharmacol Soc. 2004;47(February 2004):134–6. 23. Dorleijn DMJ, Luijsterburg PAJ, Burdorf A, Rozendaal RM, Verhaar JAN, Bos PK, Bierma-Zeinstra SMA. Associations between weather conditions and clinical symptoms in patients with hip osteoarthritis: A 2-year cohort study. Pain. 2014;155(4):808–13. 24. Falkenbach A, Schuh A, Wigand R. Pain in ankylosing spondylitis- the impact of the weather. Int J Environ Health Res. 1998;8(1):85–9.25. Ng J, Scott D, Taneja A, Gow P, Gosai A. Weather changes and pain in rheumatology patients. APLAR J Rheumatol. 2004;7(3):204–6. 26. Jamison RN, Anderson KO, Slater MA. Weather changes and pain: perceived influence of local climate on pain complaint in chronic pain patients. Pain. 1995;61(2):309–15.