The Association of Body Mass Index with Platelets, Leukocytes and C-reactive Protein Values in Postmenopausal Women

Öz

To evaluate the association of body mass index with the inflammatory markers such as platelets, leukocytes and C-reactive protein levels in postmenopausal women. The present retrospective study was performed among postmenopausal women who admitted to Eskisehir Osmangazi University. The clinical and laboratory findings were analyzed retrospectively. The body mass index values were categorized as three groups. Demographic characteristics, clinical and laboratory datas were analyzed with parametric or non-parametric tests according to the distribution of the datas.  The correlation analysis was carried out to determine the relationship between body mass index and clinical findings. One thousand three hundred and sixty-nine patients were evaluated, women who did not met inclusion criterias were excluded. After exclusion criterias, totally 782 patients were analyzed. Mean age(years) and age of menopause(years) were 49.8±5.4 and 46.0±4.9 respectively. Women were divided into three groups according to the body mass index(kg/m2) as <25, 25-30 and >30. The blood pressure values were increased with higher body mass index significantly(p=0.001). Although the platelet counts were not different between groups, we determined that leukocytes and C-reactive protein levels were higher in obese subjects compared to normal body weight. Menopausal status is a period which is accompanied by many chronic diseases and can be seen with serious morbidity such as obesity. In the postmenopausal women, complete blood count and especially inflammatory markers can be evaluated as a routine and easy examination method. In the present study that was related with the triggering of an inflammatory process by obesity, it was observed that the inflammatory markers such as the platelet, leukocyte counts and C-reactive protein levels increased with the increase in body mass index.

Anahtar Kelimeler

• menopause,obesity,platelet,leukocyte

Postmenopozal Kadınlarda Vücut Kitle İndeksi ile Trombosit, Lökosit ve C-reaktif Protein Seviyesinin İlişkisi

Öz

Postmenopozal dönemdeki kadınlarda inflamatuar belirteçler olan trombosit, lökosit ve C-reaktif protein değerlerinin vücut kitle indeksi ile ilişkisinin belirlenmesi. Araştırmamız retrospektif olarak Eskişehir Osmangazi Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Polikliniğine başvuran menopozal döneminde olan kadınların değerlendirilen klinik ve laboratuar bulgularının incelenmesi şeklinde planlanmıştır. Bu bulgular vücut kitle indeksi değerlerinin kategorizasyonu ile üç grup halinde karşılaştırılmıştır. Demografik veriler, klinik ve laboratuar bulguları parametrik ve non-parametrik testler ile analiz edilmiştir. Vücut kitle indeksi ile laboratuar ve kan basıncı değerlerinin korelasyon analizleri gerçekleştirilmiştir. Retrospektif analizde 1369 hasta değerlendirilmiş, dışlanma kriterleri sonrası ve verilerine ulaşılamayan hastalar çalışma dışı bırakıldıktan sonra toplamda 782 hasta çalışma grubu olarak belirlenerek analizler gerçekleştirilmiştir. Hastaların ortalama yaş ve menopoz yaşı sırasıyla 49.8±5.4 ve 46.0±4.9 olarak tespit edilmiştir. Vücut kitle indeksi(kg/m2) değerlerine göre üç ayrı grup olarak analizler gerçekleştirilmiştir(<25, 25-30 ve >30). Kan basıncı ölçümlerinin vücut kitle indeksi artışı ile istatistiksel olarak anlamlı düzeyde artış gösterdiği tespit edilmiştir(p=0.001). Trombosit değerlerinde gruplar arası anlamlılık tespit edilemezken, lökosit ve C-reaktif protein düzeyleri vücut kitle indeksinin artışı ile yükseldiği gözlenmiştir. Menopozal dönem bir çok kronik hastalığın eşlik ettiği ve özellikle obezite gibi ciddi morbidite ile seyredebilecek bir dönemdir. Bu dönemde rutin ve kolay inceleme yöntemi olarak tam kan sayımı ile özellikle inflamatuar belirteçlerin değerlendirmesi yapılabilmektedir. Obezitenin inflamatuar bir süreci tetiklemesi ile ilişkili çalışmamızda da trombosit, lökosit ve C-reaktif protein gibi inflamatuar belirteçlerin vücut kitle indeksi artışı ile korele şekilde yükseldiği gözlenmiştir.

Anahtar Kelimeler

• menopoz,obezite,trombosit,lökosit,c-reaktif protein

Kaynakça

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