Çinko Tedavisi Ani İşitme Kaybında Etkili Olabilir mi?

Öz

Ani işitme kaybı (AİK) tedavisinde hem bir anti-inflamatuvar hem de bir antioksidan olan çinkonun etkinliğini araştırmaktır. Bu çalışma etik kurul onayı alındıktan sonra retrospektif olarak üçüncü basamak sağlık kuruluşunda yapılmıştır. Çalışmaya 18- 65 yaş aralığında, AİK tedavisi için sistemik steroid ya da sistemik steroid ile birlikte çinko kullanılan hastalar dahil edilmiştir. Hastalar kullanılan tedavi çeşidine göre iki gruba ayrıldı. Tedavide sistemik steroid kullanılan hastalar Grup 1’e, sistemik steroide ilave olarak çinko kullanılan hastalar ise Grup 2’ye dahil edildi. Tedavi etkinliğini değerlendirmek için işitme geri dönüş yüzdesi, işitme kazancı ve Furuhashi kriterleri kullanıldı. Grup 1 ve Grup 2 tedavi etkinliği açısından karşılaştırıldı. Çalışmaya, dahil edilme kriterlerini sağlayan Grup 1 de 40, Grup 2 de 36 olmak üzere toplam 76 hasta dahil edilmiştir. İki grup demografik verileri (yaş, cinsiyet), işitme kaybı geçirilen kulağın tarafı, işitme kaybına vertigo ve tinnitusun eşlik edip etmemesi, hastaların mevcut sistemik hastalıkları, ÜSYE varlığı ve işitme azlığı şikayetinin başlaması ile tedavi başlangıcı arasında geçen süre açısından karşılaştırıldığında, gruplar arasında istatistiksel olarak anlamlı fark saptanmadı. Grupların tedavi etkinliği; işitme kazançları, işitme geri dönüş yüzdeleri ve Furuhashi kriterleri kullanılarak karşılaştırıldı ve gruplar arasında her üç parametrede de istatistiksel olarak anlamlı fark bulunmadı (sırasıyla p=0,815, p= 0,626, p= 0,853). AİK tedavisinde sistemik steroide çinko eklenmesi sonucunda iyileşme parametrelerinde istatistiksel olarak anlamlı bir değişim saptanmamıştır. Çinkonun AİK tedavisinde günümüz koşullarında kullanımının gerekli olmadığını düşünmekteyiz.

Anahtar Kelimeler

• çinko
• ani işitme kaybı
• tedavi
• antioksidan
• antiinflamatuvar

Can Zinc Treatment Be Effective for Sudden Hearing Loss?

Öz

To investigate the efficacy of zinc, which is both an anti-inflammatory and an antioxidant, in the treatment of sudden sensorineural hearing loss (SSNHL). The present study was carried out retrospectively at a territory reference center upon the approval of the local ethics committee. Patients between the ages of 18-65 who used systemic steroid or zinc with systemic steroids for the treatment of SSNHL were included in the study. The patients were divided into two groups according to the type of treatment used. The patients who used systemic steroids were included in Group 1, and the patients who used zinc in addition to systemic steroids were included in Group 2. Recovery rate, hearing gain, and Furuhashi criteria were used to evaluate the treatment efficacy. Group 1 and Group 2 were compared in terms of treatment efficiency. A total of 76 patients, 40 in Group 1 and 36 in Group 2, who met the inclusion criteria, were included in the study. When the two groups were compared in terms of demographic data (age, gender), side of the ear with hearing loss, whether the disease was accompanied by vertigo and tinnitus, the patients' existing systemic diseases, the presence of upper respiratory tract infection, and the time elapsed between the onset of hearing loss and the beginning of treatment, there was no statistically significant difference between the groups.Treatment efficacies of groups were compared using the hearing gain, recovery rate, and Furuhashi criteria, and there was no statistically significant difference in all three parameters between the groups. (p = 0.815, p = 0.626, p = 0.853, respectively). As a result of the addition of zinc to systemic steroid in SSNHL treatment, no statistically significant change was found in healing parameters. We think that it is not necessary to use zinc in the treatment of SSNHL in today's conditions.

Anahtar Kelimeler

• zinc
• sudden sensorineural hearing loss
• treatment
• antioxidant
• anti-inflammatory

Kaynakça

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