Tip 2 Diyabetli Hastalarda Kırılganlık Sendromunun Sıklığı ve Klinik Önemi

Öz

Bu çalışmada tip 2 diyabetes mellitusta (T2DM) kırılganlık sendromunun sıklığını ve kırılganlık ile T2DM arasındaki ilişkiyi değerlendirmeyi amaçladık. Çalışmaya T2DM tanılı yüz yirmi beş hasta dahil edildi. Fried'in kırılganlık ölçeğine göre hastalar kırılgan, pre-kırılgan ve kırılgan olmayan olarak gruplandırıldı ve sıklıkları belirlendi. Gruplar arasında demografik veriler, antropometrik ölçümler ve laboratuvar verileri karşılaştırıldı. Grup büyüklüğü eşit olmadığı için grup büyüklüklerinin harmonik ortalaması kullanılmıştır. Çalışmada kırılgan hasta sayısı 11 (%8), pre-kırılgan hasta sayısı 83 (%66), kırılgan olmayan hasta sayısı 31 (%26) idi. Kırılgan grubun ortanca yaşı 65 (51-88) yıl, pre-kırılgan grubun 61 (50-78) yıl ve kırılgan olmayan grup 61 (50-80) yıl (p=0.15) idi. Gruplar arasında vücut kitle indeksi, diyabet süresi, sistolik ve diyastolik kan basıncı ve komorbidite açısından istatistiksel olarak anlamlı fark yoktu (hepsi için p> 0.05). Açlık plazma glukozu, HbA1c, trigliserit, el kavrama gücü ve yürüme hızı gruplar arasında istatistiksel olarak farklı bulundu (tümü için p< 0.05). Pre-frail T2DM'li hastalarda bozulmuş glukoz regülasyonu, düşük yürüme hızı ve el kavrama gücü saptandı. T2DM'li hastalar daha erken yaşta kırılganlık için adaydır.

Anahtar Kelimeler

• kırılganlık
• yürüme hızı
• el kavrama gücü
• tip 2 diabetes mellitus

Clinical Significance and Prevalence of Frailty Syndrome in Type 2 Diabetes Patients

Öz

In this study, we aimed to evaluate the prevalence of frailty in type 2 diabetes mellitus (T2DM) and to investigate the relations between frailty and T2DM. One hundred twenty-five patients with T2DM diagnosis were included in the study. According to the Fried's frailty scale, the patients were grouped as frail, pre-frail and non-frail, and their prevalence was determined. Demographic data, anthropometric measurements and laboratory data were compared between the groups. The harmonic mean of the group sizes is used as the group size was not equal. The frail patients’ number was 11 (8%), the pre-frail patients’ number was 83 (66%), and the non-frail patients’ number was 31 (26%) in the study. The median age of the frail group was 65 (51-88) years, the pre-frail group was 61 (50-78) years, and the non-frail group was 61 (50-80) years (p = 0.15). There was no statistically significant difference between in body mass index, diabetes duration, systolic and diastolic blood pressure, and co-morbidity between the groups (p> 0.05 for all). Fasting plasma glucose, HbA1c, triglyceride, hand grip strength and gait speed were statistically significantly different between groups (p< 0.05 for all). Impaired glucose regulation, low gait speed and hand grip strength test were detected in patients with pre-frail T2DM. Patients with T2DM are candidates for frailty at an earlier age.

Anahtar Kelimeler

• frailty
• gait speed
• handgrip strength
• type 2 diabetes mellitus

Kaynakça

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