Endokrinoloji Pratiğinde Serebral Kalsifikasyon/Cerebral Calcification In General Endocrine Practice

Yıl 2017, Cilt: 39 Sayı: 1, 21 - 25, 07.01.2017

Güven Barış Cansu , Bengür Taşkıran Eylem Bahadır

https://doi.org/10.20515/otd.69389

Öz

Özet: Bazal ganglion kalsifikasyonu bilgisayarlı
beyin tomografisinde sıklıkla rastlanan bir durum olup birçok etiyolojik nedeni
vardır. İdyopatik olanları Fahr hastalığı olarak bilinir. Paratiroid
hastalıkları, sekonder nedenlerin başını çeker. Bu retrospektif çalışmada
bilateral bazal ganglion kalsifikasyonu saptanan hastalarda paratiroid
hastalıkları değerlendirilmiştir. Ocak 2013-Nisan 2016 tarihleri arasında
Endokrinoloji ve Metabolizma Hastalıkları polikliniğine serebral kalsifikasyon
nedeni ile başvurup endokrinolojik hastalıklar açısından tetkik edilmiş
hastalar geriye dönük olarak taranmıştır. Hastaların klinik, laboratuvar ve
radyolojik görüntüleme sonuçları dosyalarından ve elektronik kayıt sisteminden
elde edilmiştir. Çalışmaya toplam 14 hasta alınmıştır. Bu hastalardan çalışmaya
alınma kriterlerine uyan 6 hastanın 3’ünde etyolojik neden saptanmazken
(idyopatik), 3’ünde tiroid cerrahisine sekonder gelişen iyatrojenik
hipoparatiriodizm saptandı. Tipik radyolojik görünümü olmayan hastalarda D
vitamini eksikliği ve buna bağlı sekonder hiperparatiroidizm dışında ek bulgu
saptanmadı. Bilateral bazal ganglion kalsifikasyonlarının idyopatik olanları
dışında, kalsifikasyona neden olan durumlar içerisinde paratiroid hastalıklarının
(idyopatik ya da iyatrojenik hipoparatiroidizm) önemli bir yer tuttuğu
bilinmeli ve hastalar mutlaka endokrinolojik açıdan değerlendirilmelidir.

Anahtar Kelimeler: Bazal
gangliyon kalsifikasyonu, Fahr hastalığı, hipoparatiroidizm

 

 

Abstract: Basal ganglion calcification is a common incidental
finding in computed tomography of brain. There is a number of causes for
etiology. Idiopathic cases are named as Fahr disease. Parathyroid diseases
leads the secondary causes. In this retrospective evaluation, we evaluated
parathyroid diseases in patients with basal ganglion calcification. We
evaluated retrospectively medical records of patients who were referred to
endocrinology outpatient clinic between January 2013 to April 2016 due to
cerebral calcification. Clinical features, laboratory data, and imaging were
evaluated. Fourteen patients were evaluated. Three out of 6, who met inclusion
criteria, were idiopathic cases and 3 had iatrogenic hypoparathyroidism which
developed as a complication after thyroid surgery. In the remaining 7 patients,
typical radiologic findings were absent and secondary hyperparathyroidism due
to vitamin D deficiency was evident as the sole endocrinopathology. Aside from
idiopathic cases, it should be kept in mind that parathyroid diseases (either
idiopathic or iatrogenic hypoparathyroidism) play an important role in basal
ganglion calcification and the patients should be sought for it.

Keywords: Basal
ganglion calcification, Fahr’sdisease, hypoparathyroidism

Anahtar Kelimeler

Bazal gangliyon kalsifikasyonu, Fahr hastalığı

Kaynakça

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