Growth Hormone Treatment Indications in Children and Adolescents

Yıl 2017, Cilt: 39 Sayı: 3, 104 - 114, 20.09.2017

Enver Simsek , Tülay Şimşek

https://doi.org/10.20515/otd.307196

Öz

Abstract: Until 1985 growth hormone (GH) was obtained from
pituitary extracts, and was available in limited amounts only to treat severe
growth hormone deficiency. Recombinant human GH has replaced human
pituitary-derived GH, which should no longer be used because of the risk of
contamination with the Jakob Creutzfeld prion. Although with some differences
between different countries, GH treatment is indicated in children with growth
hormone defixiency, Turner syndrome, chronic renal insufficiency, Prader-Willi
syndrome, deletions/mutations of the SHOX gene, as well as in short children
born small for gestational age and with idiopathic short stature. For pediatric
patients, guidelines fort he use of GH have been developed by several
organizations that have identified specific criteria for initiating GH therapy.
In this manuscript, we summarize the growth hormone treatment indications among
pediatric and transition patients. 

Anahtar Kelimeler

growth hormone; turner syndrome, prader-willi syndrome, shox deficiency, small for gestational age

Çocuklarda ve Ergenlerde Büyüme Hormonu Tedavisi Endikasyonları

Öz

Öz: 1985 yılına kadar büyüme hormonu hipofizer
ekstrelerinden elde ediliyordu ve çok sınırlı sayıda ciddi büyüme hormonu
eksikliği (BHE) olan hastalarda kullanılıyordu. Rekombinant DNA teknolojisi ile
BH yeterli miktarda üretilmeye başlandıktan sonra çocuklarda büyüme hormonu
tedavi endikasyonları genişleyerek, büyüme hormonu eksikliği olmayan
hastalıklara bağlı boy kısalıklarında da kullanılmaya başladı. Ülkeler arasında
BH tedavi endikasyonları farklılık göstermekle birlikte, BH tedavi
endikasyonları içerisine BHE, Turner sendromu (TS), kronik böbrek yetmezliği
(KBY), Prader-Willi sendromu (PWS), SHOX geni delsyonu veya mutasyonu,
gestasyon yaşına göre düşük doğum ağırlıklı (SGA) ve boy kısalığı olan çocuklar
ve idiopatik boy kısalıkları girmektedir. Pediatrik hastalar için birçaok
organizasyon tarafından büyüme hormonu tedavisinin başlanması kriterleri
tanımlanmıştır. Biz bu yazıda pediatrik ve adölesan hastalarda büyüme hormonu
tedavisi endikasyonlarını özetledik. 

Anahtar Kelimeler

Büyüme hormonu; boy kısalığı

Kaynakça

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