Endoplazmik Retikulum Stresi ve İlişkili Hastalıklar

Yıl 2019, Cilt: 41 Sayı: 3, 294 - 303, 01.07.2019

Musa Tatar , Tuğba Tatar

https://doi.org/10.20515/otd.417682

Cited By: 1

Öz

Endoplazmik retikulum, lipid ve
protein sentezi, protein katlanması, kalsiyum homeostazı gibi çeşitli
fonksiyonları gerçekleştiren bir organeldir. Bu organelde katlanmamış veya
yanlış katlanmış proteinlerin artması ve birikimi sonucu, organel homeostazında
değişiklikler meydana gelmektedir. Bu durum organelin fonksiyonlarını bozarak
endoplazmik retikulum stresine neden olmaktadır. Katlanmamış proteinler,
protein kümelerini oluşturmaya eğilimli olan ve protein içerisinde bulunan
hidrofobik aminoasit kalıntılarını ortaya çıkarmaktadır. Oldukça toksik olan bu
protein kümelerinin birçok hastalıkla ilişkisinin olduğu bilinmektedir.
Endoplazmik retikulum stresi nörodejeneratif hastalıklar, metabolik
hastalıklar, arteriosklerozis, diabetes mellitus ve obezitede ortaya
çıkmaktadır. Endoplazmik retikulum stresi ayrıca kanserle de
ilişkilendirilmiştir. Bu derlemede endoplazmik retikulum stresinin çeşitli
hastalıklar ile ilişkisi irdelenmiştir.

Anahtar Kelimeler

Endoplazmik retikulum stresi, Nörodejeneratif hastalıklar, Metabolik hastalıklar, kanser

Endoplasmic Reticulum Stress and Related Diseases

Öz

Endoplasmic reticulum is an
organelle that performs various functions such as lipid and protein synthesis,
protein folding, calcium homeostasis. In this organelle, an increase and
accumulation in unfolded or misfolded proteins result in changes in homeostasis
of the organelle. This disrupts functions of the organelle and causes
endoplasmic reticulum stress. Unfolded proteins reveal hydrophobic amino acid
residues in the protein that are prone to form protein clusters. It is known
that these protein clusters, which are highly toxic, are related to many
diseases. Endoplasmic reticulum stress is seen in neurodegenerative diseases,
metabolic diseases, arteriosclerosis, diabetes mellitus and obesity.
Endoplasmic reticulum stress is also associated with cancer. In this review,
the relationship between endoplasmic reticulum stress and various diseases has
been examined.

Anahtar Kelimeler

Endoplasmic reticulum stress, Neurodegenerative diseases, Metabolic diseases, Cancer

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