Artriti olmayan Psoriasis Hastalarinda Kemik Mineral Yoğunluğunun Değerlendirilmesi

Yıl 2019, Cilt: 41 Sayı: 4, 353 - 359, 01.10.2019

Senem Şaş Hilal Kaya Erdoğan İşıl Bulur

https://doi.org/10.20515/otd.433038

Öz

Çalışmamızda eklem tutulumu olmayan psoriasis
hastalarında kemik mineral yoğunluğunu (KMY) değerlendirilerek sağlıklı kontrol
grubu ile karşılaştırmayı ve topikal kortikosteroid ve sistemik tedavi kullanımının
KMY üzerine etkisini göstermeyi amaçladık.
Çalışmaya hastanemiz dermatoloji polikliniğine başvuran 40 psoriasis
hastası ve 36 sağlıklı gönüllü dahil edildi. Hasta ve kontrol grubunun lomber
ve femur KMY ölçüldü. Psoriazis ve sağlıklı
kontrol gruplarında KMY açısından istatistiksel olarak anlamlı bir fark
bulunmadı. Topikal ve sistemik tedavi alan psoriasisli hastaların L1-L4
skorları, femur KMY, L1-L4 BMD, femur Z, omurga Z ve kalsiyum değerleri
karşılaştırıldığında, istatistiksel olarak anlamlı fark bulunmadı. Topikal
tedavi alan grupta femur boynu T skoru, sistemik tedavi alan gruba göre anlamlı
olarak daha yüksekti. Hastalık  süresi ve
şiddeti arasında istatistiksel olarak anlamlı fark yoktu. L1-L4 skorları, L1-L4
BMD, omurga Z, kalsiyum değerleri, tırnak tutulumu ve tırnak tutulumu olmayan
gruplar arasında anlamlı farklılık göstermedi. Ancak femur boynu, femur total
ve femur Z skorları tırnak tutulumu olan grupta tırnak tutulumu olmayan gruba
göre anlamlı olarak düşüktü.Bu
çalışma psoriasisli hastalarında, KMY’nin sağlıklı kontrol grubundan farklı
olmadığını göstermektedir.

Anahtar Kelimeler

kemik mineral yoğunluğu, osteoporoz, artrit, sedef

Assessment of Bone Mineral Density in Psoriasis Patients without Arthritis

Öz

In this study, we
aimed to investigate the bone mineral density (BMD) of psoriasis patients,
compare with healthy control group, and to evaluate whether topical corticosteroids
and systemic treatments affect BMD in psoriasis patients. Forty psoriasis
patients admitted to dermatology outpatient clinic and 36 healthy subjects were
included in the study. Lumbar and femur BMD of patient and control groups were
measured. No statistically
significant difference was found with regard to BMD in psoriasis and healthy
control groups. When we compare the L1-L4 scores, femur BMD, L1-L4 BMD, femur
Z, spine Z, and values of the psoriasis patients who receiving topical and
systemic treatments, we did not found statistically significant difference.
Femur neck T score was significantly higher in the group receiving topical
treatment than in the group receiving systemic treatment. There were not
statistically significant difference between disease duration and severity.
The
L1-L4 scores, L1-L4 BMD, spine Z values did not differ significantly between
nail involvement and non-nail involvement groups. But the femur neck, femur
total and femur Z scores were significantly lower in the group with nail
involvement than group without nail involvement. This study shows that BMD of psoriasis patients is not different
from healthy control group.

Anahtar Kelimeler

psoriasis, arhritis, bone mineral density, osteoporosis

Kaynakça

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