Cancer is defined as an uncontrolled proliferation of cells. Periodontitis is a chronic disease and characterized by loss of attachment and alveolar bone destruction caused by inflammatory and immune reactions induced by microbial dental plaque. In this study, we aimed to evaluate the interaction between oral cancer and periodontitis. The literature search was conducted in publications before March 2019, was searched the keywords of "periodontitis" and "oral cancer" in the Pubmed database. Studies that are evaluated according to oral hygiene, do not evaluate head and neck cancer, and whose full text is not available, were excluded. 17 studies investigating the relationship between oral cancers and periodontitis were included in the evaluation. 47.06% of studies were case control, 17.65% were cross-sectional, 11.76% were meta-analysis and 23.53% were in cohort study design. The included studies report that there is a relationship between periodontitis and oral cancer. There are studies indicating that saliva S100P mRNA may be a biomarker for oral squamous cell carcinoma and P. gingivalis may be a microbial marker for the risk of oro-digestive cancer mortality. It has been reported that there may be a relationship between periodontitis and cancer. If the relationship is confirmed, periodontitis patients can be considered high-risk and screened for oral cancer. Therefore, early diagnosis and survival rates can be improved. Prospective studies are needed.
Birincil Dil | Türkçe |
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Konular | Sağlık Kurumları Yönetimi |
Bölüm | DERLEMELER / REVIEWS |
Yazarlar | |
Yayımlanma Tarihi | 28 Eylül 2020 |
Yayımlandığı Sayı | Yıl 2020 Ağız Kanserleri Özel Sayısı |