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The Relationship of Oral Cancer and Periodontal Disease

Yıl 2020, Ağız Kanserleri Özel Sayısı, 241 - 248, 28.09.2020
https://doi.org/10.20515/otd.771917

Öz

Cancer is defined as an uncontrolled proliferation of cells. Periodontitis is a chronic disease and characterized by loss of attachment and alveolar bone destruction caused by inflammatory and immune reactions induced by microbial dental plaque. In this study, we aimed to evaluate the interaction between oral cancer and periodontitis. The literature search was conducted in publications before March 2019, was searched the keywords of "periodontitis" and "oral cancer" in the Pubmed database. Studies that are evaluated according to oral hygiene, do not evaluate head and neck cancer, and whose full text is not available, were excluded. 17 studies investigating the relationship between oral cancers and periodontitis were included in the evaluation. 47.06% of studies were case control, 17.65% were cross-sectional, 11.76% were meta-analysis and 23.53% were in cohort study design. The included studies report that there is a relationship between periodontitis and oral cancer. There are studies indicating that saliva S100P mRNA may be a biomarker for oral squamous cell carcinoma and P. gingivalis may be a microbial marker for the risk of oro-digestive cancer mortality. It has been reported that there may be a relationship between periodontitis and cancer. If the relationship is confirmed, periodontitis patients can be considered high-risk and screened for oral cancer. Therefore, early diagnosis and survival rates can be improved. Prospective studies are needed.

Kaynakça

  • 1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA: a cancer journal for clinicians. 2011;61(2):69-90.
  • 2. Schwartz LH, Ozsahin M, Zhang GN, et al. Synchronous and metachronous head and neck carcinomas. Cancer. 1994;74(7):1933-8.
  • 3. Karin M, Lawrence T, Nizet V. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell. 2006;124(4):823-35.
  • 4. Lax AJ, Thomas W. How bacteria could cause cancer: one step at a time. Trends in microbiology. 2002;10(6):293-9.
  • 5. Loesche WJ, Grossman NS. Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment. Clin Microbiol Rev. 2001;14(4):727-52
  • 6. Divaris K, Olshan AF, Smith J, et al. Oral health and risk for head and neck squamous cell carcinoma: the Carolina Head and Neck Cancer Study. Cancer Causes Control. 2010;21(4):567-75.
  • 7. Laprise C, Shahul HP, Madathil SA, et al. Periodontal diseases and risk of oral cancer in Southern India: Results from the HeNCe Life study. Int J Cancer. 2016;139(7):1512-9.
  • 8. Heikkila P, But A, Sorsa T, Haukka J. Periodontitis and cancer mortality: Register-based cohort study of 68,273 adults in 10-year follow-up. Int J Cancer. 2018;142(11):2244-53.
  • 9. Tezal M, Sullivan MA, Reid ME, et al. Chronic periodontitis and the risk of tongue cancer. Archives of Otolaryngology–Head & Neck Surgery. 2007;133(5):450-4.
  • 10. Tezal M, Sullivan MA, Hyland A, et al. Chronic periodontitis and the incidence of head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2009;18(9):2406-12.
  • 11. Tezal M, Grossi SG, Genco RJ. Is periodontitis associated with oral neoplasms? J Periodontol. 2005;76(3):406-10.
  • 12. Rezende CP, Ramos MB, Daguila CH, et al. Oral health changes in with oral and oropharyngeal cancer. Braz J Otorhinolaryngol. 2008;74(4):596-600.
  • 13. Ahn J, Segers S, Hayes RB. Periodontal disease, Porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality. Carcinogenesis. 2012;33(5):1055-8.
  • 14. Moergel M, Kammerer P, Kasaj A, et al. Chronic periodontitis and its possible association with oral squamous cell carcinoma - a retrospective case control study. Head Face Med. 2013;9:39.
  • 15. Eliot MN, Michaud DS, Langevin SM, et al. Periodontal disease and mouthwash use are risk factors for head and neck squamous cell carcinoma. Cancer Causes Control. 2013;24(7):1315-22.
  • 16. Wen B-W, Tsai C-S, Lin C-L, et al. Cancer risk among gingivitis and periodontitis patients: a nationwide cohort study. QJM: An International Journal of Medicine. 2014;107(4):283-90.
  • 17. Chung SD, Tsai MC, Huang CC, et al. A population-based study on the associations between chronic periodontitis and the risk of cancer. Int J Clin Oncol. 2016;21(2):219-23.
  • 18. Moraes RC, Dias FL, Figueredo CM, et al. Association between Chronic Periodontitis and Oral/Oropharyngeal Cancer. Braz Dent J. 2016;27(3):261-6.
  • 19. Cheng YL, Jordan L, Chen HS, et al. Chronic periodontitis can affect the levels of potential oral cancer salivary mRNA biomarkers. J Periodontal Res. 2017;52(3):428-37.
  • 20. Shin YJ, Choung HW, Lee JH, et al. Association of Periodontitis with Oral Cancer: A Case-Control Study. J Dent Res. 2019;98(5):526-33.
  • 21. Yao QW, Zhou DS, Peng HJ, et al. Association of periodontal disease with oral cancer: a meta-analysis. Tumour Biol. 2014;35(7):7073-7.
  • 22. Zeng XT, Deng AP, Li C, et al. Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies. PLoS One. 2013;8(10):e79017.
  • 23. Bueno AC, Ferreira RC, Cota LO, et al. Comparison of different criteria for periodontitis case definition in head and neck cancer individuals. Support Care Cancer. 2015;23(9):2599-604.
  • 24. Ord RA, Blanchaert Jr RH. Oral cancer: The dentist’s role in diagnosis, management, rehabilitation, and prevention: Chicago; 2000.
  • 25. Homann N, Tillonen J, Rintamäki H, et al. Poor dental status increases acetaldehyde production from ethanol in saliva: a possible link to increased oral cancer risk among heavy drinkers. Oral oncology. 2001;37(2):153-8.

Oral Kanser ve Periodontal Hastalık İlişkisi Disease

Yıl 2020, Ağız Kanserleri Özel Sayısı, 241 - 248, 28.09.2020
https://doi.org/10.20515/otd.771917

Öz

Hücrelerin kontrolsüz çoğalmasından oluşan hastalık grupları kanser olarak tanımlanmaktadır. Periodontitis mikrobiyal dental plak tarafından uyarılan enflamatuar ve immun reaksiyonlar sonucu oluşan ataçman kaybı ve alveol kemik yıkımı ile karakterize kronik bir hastalıktır. Bu literatür incelemesinde, oral kanser ve periodontitis arasındaki etkileşimin bilimsel bulgular ışığında değerlendirilmesi amaçlanmıştır. Pubmed veritabanında, “periodontitis” ve “oral kanser” anahtar kelimeleri kullanılarak Mart 2019'dan önceki yayınlarda literatür taraması yapılmıştır. Ağız hijyenine göre değerlendirilen, baş-boyun kanserini değerlendirmeyen ve tam metinine ulaşılamayan çalışmalar çıkarılmıştır. Oral kanserler ile periodontitis ilişkisini araştıran 17 çalışma değerlendirmeye katılmıştır. Dahil edilen araştırmaların %47,06’sı vaka kontrol, %17,65’i kesitsel, %23,53’ü kohort ve %11,76’sı meta-analiz çalışma tasarımındadır. Dahil edilen çalışmalar periodontitis ile oral kanser arasında ilişki olduğunu bildirmektedir. Oral skuamöz hücreli karsinoma için tükürük S100P mRNA'sının biyobelirteç olarak kullanılabileceği belirtilmiştir. Orodigestive kanser mortalite riski için P.gingivalis'in mikrobiyal belirteç olarak kullanılabileceği bildirilmiştir. Literatürde varolan kısıtlı çalışmalar, periodontitis ile kanser arasında ilişki olabileceğini bildirmişlerdir. Oral kanser-periodontitis arasındaki ilişki doğrulanırsa, periodontitis hastaları kanser açısından taranabilir ve erken tanı ile sağ-kalım oranları iyileştirilebilir. Periodontitis ile kanser ilişkisini doğrulamak ve sebep-sonuç ilişkisini daha net tanımlayabilmek için histolojik inceleme yapılan prospektif çalışmalara ihtiyaç vardır.

Kaynakça

  • 1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA: a cancer journal for clinicians. 2011;61(2):69-90.
  • 2. Schwartz LH, Ozsahin M, Zhang GN, et al. Synchronous and metachronous head and neck carcinomas. Cancer. 1994;74(7):1933-8.
  • 3. Karin M, Lawrence T, Nizet V. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell. 2006;124(4):823-35.
  • 4. Lax AJ, Thomas W. How bacteria could cause cancer: one step at a time. Trends in microbiology. 2002;10(6):293-9.
  • 5. Loesche WJ, Grossman NS. Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment. Clin Microbiol Rev. 2001;14(4):727-52
  • 6. Divaris K, Olshan AF, Smith J, et al. Oral health and risk for head and neck squamous cell carcinoma: the Carolina Head and Neck Cancer Study. Cancer Causes Control. 2010;21(4):567-75.
  • 7. Laprise C, Shahul HP, Madathil SA, et al. Periodontal diseases and risk of oral cancer in Southern India: Results from the HeNCe Life study. Int J Cancer. 2016;139(7):1512-9.
  • 8. Heikkila P, But A, Sorsa T, Haukka J. Periodontitis and cancer mortality: Register-based cohort study of 68,273 adults in 10-year follow-up. Int J Cancer. 2018;142(11):2244-53.
  • 9. Tezal M, Sullivan MA, Reid ME, et al. Chronic periodontitis and the risk of tongue cancer. Archives of Otolaryngology–Head & Neck Surgery. 2007;133(5):450-4.
  • 10. Tezal M, Sullivan MA, Hyland A, et al. Chronic periodontitis and the incidence of head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2009;18(9):2406-12.
  • 11. Tezal M, Grossi SG, Genco RJ. Is periodontitis associated with oral neoplasms? J Periodontol. 2005;76(3):406-10.
  • 12. Rezende CP, Ramos MB, Daguila CH, et al. Oral health changes in with oral and oropharyngeal cancer. Braz J Otorhinolaryngol. 2008;74(4):596-600.
  • 13. Ahn J, Segers S, Hayes RB. Periodontal disease, Porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality. Carcinogenesis. 2012;33(5):1055-8.
  • 14. Moergel M, Kammerer P, Kasaj A, et al. Chronic periodontitis and its possible association with oral squamous cell carcinoma - a retrospective case control study. Head Face Med. 2013;9:39.
  • 15. Eliot MN, Michaud DS, Langevin SM, et al. Periodontal disease and mouthwash use are risk factors for head and neck squamous cell carcinoma. Cancer Causes Control. 2013;24(7):1315-22.
  • 16. Wen B-W, Tsai C-S, Lin C-L, et al. Cancer risk among gingivitis and periodontitis patients: a nationwide cohort study. QJM: An International Journal of Medicine. 2014;107(4):283-90.
  • 17. Chung SD, Tsai MC, Huang CC, et al. A population-based study on the associations between chronic periodontitis and the risk of cancer. Int J Clin Oncol. 2016;21(2):219-23.
  • 18. Moraes RC, Dias FL, Figueredo CM, et al. Association between Chronic Periodontitis and Oral/Oropharyngeal Cancer. Braz Dent J. 2016;27(3):261-6.
  • 19. Cheng YL, Jordan L, Chen HS, et al. Chronic periodontitis can affect the levels of potential oral cancer salivary mRNA biomarkers. J Periodontal Res. 2017;52(3):428-37.
  • 20. Shin YJ, Choung HW, Lee JH, et al. Association of Periodontitis with Oral Cancer: A Case-Control Study. J Dent Res. 2019;98(5):526-33.
  • 21. Yao QW, Zhou DS, Peng HJ, et al. Association of periodontal disease with oral cancer: a meta-analysis. Tumour Biol. 2014;35(7):7073-7.
  • 22. Zeng XT, Deng AP, Li C, et al. Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies. PLoS One. 2013;8(10):e79017.
  • 23. Bueno AC, Ferreira RC, Cota LO, et al. Comparison of different criteria for periodontitis case definition in head and neck cancer individuals. Support Care Cancer. 2015;23(9):2599-604.
  • 24. Ord RA, Blanchaert Jr RH. Oral cancer: The dentist’s role in diagnosis, management, rehabilitation, and prevention: Chicago; 2000.
  • 25. Homann N, Tillonen J, Rintamäki H, et al. Poor dental status increases acetaldehyde production from ethanol in saliva: a possible link to increased oral cancer risk among heavy drinkers. Oral oncology. 2001;37(2):153-8.
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm DERLEMELER / REVIEWS
Yazarlar

Ebru Sağlam 0000-0002-7329-8085

Zeliha Betül Özsağır 0000-0001-7067-5263

Yayımlanma Tarihi 28 Eylül 2020
Yayımlandığı Sayı Yıl 2020 Ağız Kanserleri Özel Sayısı

Kaynak Göster

Vancouver Sağlam E, Özsağır ZB. Oral Kanser ve Periodontal Hastalık İlişkisi Disease. Osmangazi Tıp Dergisi. 2020;42(5):241-8.

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