The aim of this study was to evaluate the prognostic relevance of fascin-1 and galectin-3 that are actin proteins in laryngeal cancer. Informatios and documents of 58 patients diagnosed with advanced laryngeal squamous cell carcinoma and treated surgically were included in the study. Surgical specimen slides were stained immunohistochemically at Benchmark staining platform by Ventana Universal DAB detection kit. For each marker, least 1000 cells were counted at light microscope. For galectin-3; more than 5% staining was considered as positive, %5 and less was accepted as negative. For fascin-1; staining intensity was categorized in 4 groups; 0: no staining; 1: weak staining; 2: moderate staining; 3: strong staining,and the percentage of positive cells was grouped from 1 to 4 as follows; 1: ≤ 10 %; 2:10-50 %; 3: 50-75 %; 4: ≥75. Then, two scores gathered and final score 4 and less accepted as low staining; 5 and more accepted as high staining. Fascin-1 expression was found high in 41(70.68 %); and galectin-3 expression was found positive in 36 (62.06 %) patients. Fascin-1 and galectin-3 expressions showed no correlation with conventional prognostic factors, disease free survival and disease related death, statistically. Prognostic value of fascin-1 and galectin-3 in laryngeal cancer could not be demonstrated in this study. However, this study may contribute to the literature in this respect, as these two markers have not been studied together in any study of laryngeal cancer until now. Therefore, more studies are needed on this subject.
Birincil Dil | İngilizce |
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Konular | Sağlık Kurumları Yönetimi |
Bölüm | ORİJİNAL MAKALELER / ORIGINAL ARTICLES |
Yazarlar | |
Yayımlanma Tarihi | 7 Mayıs 2021 |
Yayımlandığı Sayı | Yıl 2021 Cilt: 43 Sayı: 3 |