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Administration of Attenuated Live Vaccines Before and After Liver Transplantation in Childhood: Single Center Experience in Turkey

Yıl 2021, Cilt 43, Sayı 3, 239 - 246, 07.05.2021
https://doi.org/10.20515/otd.809021

Öz

The aim of this study was to evaluate the attenuated live vaccine administration before and after liver transplantation. This study was carried out at the Child Health Surveillance Unit of the Social Pediatrics Department. Besides healthy children, children with special needs are being followed-up at the Unit. Each child has a personal health record in the unit. The health records of patients who had received attenuated live vaccine before liver transplantation under 1 year of age or after liver transplantation were evaluated. Demographic characteristics, data showing immunologic status before vaccination, vaccine related reactions and serologic responses were obtained from health records of each child. Retrospective files of 5 patients who were in follow-up were examined. Four patients at least 2 years after the liver transplantation had attenuated live vaccination (measles-mumps-rubella vaccine and / or chickenpox vaccine). No adverse reaction was noted after the immunization among these 4 children. A 6-month-15-day-old infant who was a candidate for liver transplantation had been vaccinated with measles-mumps-rubella and chickenpox vaccine and it was determined that the serological response after vaccination was not complete in the baby who did not have any adverse reactions after vaccination. Our findings demonstrated that despite the use of immusuppressive therapy, it is safe to apply attenuated live vaccines after the transplantation if appropriate conditions were provided. The timing of the rapid effective immunization before transplantation under one year of age needs to be further investigated

Kaynakça

  • 1. Rubin LG, Levin MJ, Ljungman P, et al. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host Clin Infect Dis. 2014; 58(3): 309–318.
  • 2. Chong PP, Avery RK. A comprehensive review of immunization practices in solid organ transplant and hematopoietic stem cell transplant recipients. Clinical Therapeutics, 2017; 39(8): 1581-1598.
  • 3. Danzinger‐Isakov L, Kumar DA, AST Infectious Diseases Community of Practice. Guidelines for vaccination of solid organ transplant candidates and recipients. American Journal of Transplantation, 2009; 9: S258-S262.
  • 4. Danziger‐Isakov L, Kumar D, AST Infectious Diseases Community of Practice. Vaccination in solid organ transplantation. American Journal of Transplantation, 2013; 13: 311-317.
  • 5. Kim YJ, Kim SI. Vaccination strategies in patients with solid organ transplant: evidences and future perspectives. Clinical and Experimental Vaccine Research 2016; 5: 125-131.
  • 6. Shinjoh M, Miyairi I, Hoshino K, Takahashi T, Nakayama T. Effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation. Vaccine. 2008; 26(52): 6859–686
  • 7. Shinjoh M, Hoshino K, Takahashi T, Nakayama, T. (2015). Updated data on effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation. Vaccine, 2015; 33(5): 701-707.
  • 8. Kawano Y, Suzuki M, Kawada JI, et al. Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients. Vaccine, 2015; 33(12): 1440-1445.
  • 9. Croce E, Hatz C, Jonker EF, Visser LG, Jaeger V, Bühler S. Safety of live vaccinations on immunosuppressive therapy in patients with immune-mediated inflammatory diseases, solid organ transplantation or after bone-marrow transplantation–A systematic review of randomized trials, observational studies and case reports. Vaccine 2017; 35(9): 1216-1226,
  • 10. Posfay-Barbe KM, Pittet LF, Sottas C, et al. Varicella-zoster immunization in pediatric liver transplant recipients: safe and immunogenic. Am J Transplant. 2012;12:2974–2985
  • 11. Suresh S, Upton J, Green M, et al. Live vaccines after pediatric solid organ transplant: Proceedings of a consensus meeting, 2018. Pediatr Transplant. 2019;23(7):e13571. doi:10.1111/petr.13571
  • 12. Lochlainn LMN, de Gier B, van der Maas N et al. Immunogenicity, effectiveness, and safety of measles vaccination in infants younger than 9 months: a systematic review and meta-analysis. The Lancet Infectious Diseases, 2019; 19(11): 1235-1245.
  • 13. Gans HA, Yasukaw, LL, Sung P et al. Measles humoral and cell-mediated immunity in children aged 5–10 years after primary measles immunization administered at 6 or 9 months of age. The Journal of Infectious Diseases, 2013; 207(4): 574-582.
  • 14. Devecioğlu E, Gökçay G, Boran P, Eren T, Yılmaz G, Badur S. İlk Altı Ayda Maternal Kızamık, Kızamıkçık, Kabakulak ve Suçiçeği Antikorlarının Durumu. Mikrobiyol Bul, 2018; 52(3): 324-327.
  • 15. Moini M, Schilsky ML, Tichy EM. Review on immunosuppression in liver transplantation. World Journal of Hepatology, 2015; 7(10), 1355–1368.
  • 16. World Health Organization. Measles- Global stiuation. Erişim: https://www.who.int/csr/don/26-november-2019-measles-global_situation/en/. Son Erşim tarihi: 1.3.2020
  • 17. T.C. Sağlık Bakanlığı Genişletilmiş Bağışılama Programı Genelgesi Erişim: https://asi.saglik.gov.tr/asi-takvimi/ Genişletilmiş Bağışıklama Programı Genelgesi. Son Erişim Tarihi: 1.3.2020
  • 18. Strebel PM, Papania MJ, Gastanaduy PA, Goodson JL. Measles Vaccination. Plotkin AS, Orenstein WA, Offit PA, Edwards KM Ed. Plotkin’s Vaccines. 7. Baskı. 2018, Elsevier, China19. Karaayvaz S, Oğuz MM, Beyazova U, et al. Evaluation of measles immunity in Turkey: is it still a threat?. Turk J Med Sci. 2019; 49(1): 336–340.
  • 20. Lochlainn LMN, de Gier B, van der Maas N, et al. Effect of measles vaccination in infants younger than 9 months on the immune response to subsequent measles vaccine doses: a systematic review and meta-analysis. The Lancet Infectious Diseases, 2019; 19(11): 1246-1254.
  • 21. Principi N, Esposito S. Early vaccination: a provisional measure to prevent measles in infants. The Lancet Infectious Diseases, 2019; 19(11): 1157-1158.

Çocukluk Yaş Grubunda Karaciğer Nakli Öncesi ve Sonrası Zayıflatılmış Canlı Aşı Uygulamaları-Türkiye’den Tek Merkez Deneyimi

Yıl 2021, Cilt 43, Sayı 3, 239 - 246, 07.05.2021
https://doi.org/10.20515/otd.809021

Öz

Karaciğer nakli öncesi ve sonrası çocuklarda canlı aşı uygulamalarının değerlendirilmesidir. Çalışmamız Sosyal Pediatri Bilim Dalı Çocuk Sağlığı İzlem Birimi'nde yapılmıştır. Birimde sağlıklı çocukların yanı sıra özel ihtiyaçları olan çocuklar da takip edilmektedir. Birimde takipli her çocuğun sağlık kaydı bulunmaktadır. 1 yaşın altında karaciğer nakli öncesinde veya karaciğer nakli sonrasında zayıflatılmış canlı aşı almış hastaların sağlık kayıtları değerlendirildi. Her çocuğun sağlık kayıtlarından demografik özellikler, aşılama öncesi immünolojik durumu gösteren veriler, aşı ile ilgili reaksiyonlar ve serolojik yanıtlar kaydedildi. Takipte olan 5 hastanın geriye dönük dosya incelemendi. Bunlardan dördüne nakilden en erken 2 yıl sonra olmak üzere zayıflatılmış canşı aşı (kızamık-kızamıkçık-kabakulak ve/veya suçiçeği aşıları) uygulanmıştır. Bu dört hastanın hiçbirinde aşı sonrası bir sorun gelişmemiştir. Nakil öncesi zayıflatılmış canlı aşı uygulanan 6 ay 15 günlük bebekte kızamık- kızamıkçık-kabakulak ve suçiçeği aşıları uygulanmıştır. Aşı sonrası herhangi bir istenmeyen reaksiyon gözlenmeyen bebekte aşı sonrası serolojik yanıtın tam olmadığı belirlenmiştir. Bulgularımız nakil sonrası immunsüpresif kullanmakta olan çocuklarda gerekli değerlendirmeler sonrasında zayıflatılmış canlı aşı uygulanmasının güvenli olduğunu ortaya koymaktadır. Diğer yandan karaciğer nakli planlanan, acil aşılanması gereken 1 yaş altındaki hastalarda KKK ve suçiçeği aşı uygulamaları sonrası yeterli yanıt oluşması konusunda ayrıntılı değerlendirme gerekmektedir.

Kaynakça

  • 1. Rubin LG, Levin MJ, Ljungman P, et al. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host Clin Infect Dis. 2014; 58(3): 309–318.
  • 2. Chong PP, Avery RK. A comprehensive review of immunization practices in solid organ transplant and hematopoietic stem cell transplant recipients. Clinical Therapeutics, 2017; 39(8): 1581-1598.
  • 3. Danzinger‐Isakov L, Kumar DA, AST Infectious Diseases Community of Practice. Guidelines for vaccination of solid organ transplant candidates and recipients. American Journal of Transplantation, 2009; 9: S258-S262.
  • 4. Danziger‐Isakov L, Kumar D, AST Infectious Diseases Community of Practice. Vaccination in solid organ transplantation. American Journal of Transplantation, 2013; 13: 311-317.
  • 5. Kim YJ, Kim SI. Vaccination strategies in patients with solid organ transplant: evidences and future perspectives. Clinical and Experimental Vaccine Research 2016; 5: 125-131.
  • 6. Shinjoh M, Miyairi I, Hoshino K, Takahashi T, Nakayama T. Effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation. Vaccine. 2008; 26(52): 6859–686
  • 7. Shinjoh M, Hoshino K, Takahashi T, Nakayama, T. (2015). Updated data on effective and safe immunizations with live-attenuated vaccines for children after living donor liver transplantation. Vaccine, 2015; 33(5): 701-707.
  • 8. Kawano Y, Suzuki M, Kawada JI, et al. Effectiveness and safety of immunization with live-attenuated and inactivated vaccines for pediatric liver transplantation recipients. Vaccine, 2015; 33(12): 1440-1445.
  • 9. Croce E, Hatz C, Jonker EF, Visser LG, Jaeger V, Bühler S. Safety of live vaccinations on immunosuppressive therapy in patients with immune-mediated inflammatory diseases, solid organ transplantation or after bone-marrow transplantation–A systematic review of randomized trials, observational studies and case reports. Vaccine 2017; 35(9): 1216-1226,
  • 10. Posfay-Barbe KM, Pittet LF, Sottas C, et al. Varicella-zoster immunization in pediatric liver transplant recipients: safe and immunogenic. Am J Transplant. 2012;12:2974–2985
  • 11. Suresh S, Upton J, Green M, et al. Live vaccines after pediatric solid organ transplant: Proceedings of a consensus meeting, 2018. Pediatr Transplant. 2019;23(7):e13571. doi:10.1111/petr.13571
  • 12. Lochlainn LMN, de Gier B, van der Maas N et al. Immunogenicity, effectiveness, and safety of measles vaccination in infants younger than 9 months: a systematic review and meta-analysis. The Lancet Infectious Diseases, 2019; 19(11): 1235-1245.
  • 13. Gans HA, Yasukaw, LL, Sung P et al. Measles humoral and cell-mediated immunity in children aged 5–10 years after primary measles immunization administered at 6 or 9 months of age. The Journal of Infectious Diseases, 2013; 207(4): 574-582.
  • 14. Devecioğlu E, Gökçay G, Boran P, Eren T, Yılmaz G, Badur S. İlk Altı Ayda Maternal Kızamık, Kızamıkçık, Kabakulak ve Suçiçeği Antikorlarının Durumu. Mikrobiyol Bul, 2018; 52(3): 324-327.
  • 15. Moini M, Schilsky ML, Tichy EM. Review on immunosuppression in liver transplantation. World Journal of Hepatology, 2015; 7(10), 1355–1368.
  • 16. World Health Organization. Measles- Global stiuation. Erişim: https://www.who.int/csr/don/26-november-2019-measles-global_situation/en/. Son Erşim tarihi: 1.3.2020
  • 17. T.C. Sağlık Bakanlığı Genişletilmiş Bağışılama Programı Genelgesi Erişim: https://asi.saglik.gov.tr/asi-takvimi/ Genişletilmiş Bağışıklama Programı Genelgesi. Son Erişim Tarihi: 1.3.2020
  • 18. Strebel PM, Papania MJ, Gastanaduy PA, Goodson JL. Measles Vaccination. Plotkin AS, Orenstein WA, Offit PA, Edwards KM Ed. Plotkin’s Vaccines. 7. Baskı. 2018, Elsevier, China19. Karaayvaz S, Oğuz MM, Beyazova U, et al. Evaluation of measles immunity in Turkey: is it still a threat?. Turk J Med Sci. 2019; 49(1): 336–340.
  • 20. Lochlainn LMN, de Gier B, van der Maas N, et al. Effect of measles vaccination in infants younger than 9 months on the immune response to subsequent measles vaccine doses: a systematic review and meta-analysis. The Lancet Infectious Diseases, 2019; 19(11): 1246-1254.
  • 21. Principi N, Esposito S. Early vaccination: a provisional measure to prevent measles in infants. The Lancet Infectious Diseases, 2019; 19(11): 1157-1158.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm ORİJİNAL MAKALELER / ORIGINAL ARTICLES
Yazarlar

Gonca KESKİNDEMİRCİ (Sorumlu Yazar)
İstanbul Tıp Fakultesi
0000-0003-1797-2802
Türkiye


Zerrin ÖNAL
İstanbul Tıp Fakültesi
0000-0002-7627-7423
Türkiye


Yeşfa Şebnem ÖZBAY Bu kişi benim
İstanbul Üniversitesi
0000-0003-3473-0135
Türkiye


Esra ÖZEK
İstanbul Tıp Fakültesi
0000-0003-3712-2522
Türkiye


Selda HANÇERLİ TÖRÜN Bu kişi benim
İstanbul Tıp Fakültesi
0000-0002-3216-2413
Türkiye


Özlem DURMAZ
İstanbul Tıp Fakültesi
0000-0001-6969-9962
Türkiye


Gülbin GÖKÇAY
İstanbul Üniversitesi Çocuk Sağlığı Enstitüsü
0000-0003-1042-0407
Türkiye

Destekleyen Kurum None
Proje Numarası Noıne
Teşekkür None
Yayımlanma Tarihi 7 Mayıs 2021
Yayınlandığı Sayı Yıl 2021, Cilt 43, Sayı 3

Kaynak Göster

Bibtex @araştırma makalesi { otd809021, journal = {Osmangazi Tıp Dergisi}, issn = {1305-4953}, eissn = {2587-1579}, address = {}, publisher = {Eskişehir Osmangazi Üniversitesi}, year = {2021}, volume = {43}, pages = {239 - 246}, doi = {10.20515/otd.809021}, title = {Administration of Attenuated Live Vaccines Before and After Liver Transplantation in Childhood: Single Center Experience in Turkey}, key = {cite}, author = {Keskindemirci, Gonca and Önal, Zerrin and Özbay, Yeşfa Şebnem and Özek, Esra and Hançerli Törün, Selda and Durmaz, Özlem and Gökçay, Gülbin} }
APA Keskindemirci, G. , Önal, Z. , Özbay, Y. Ş. , Özek, E. , Hançerli Törün, S. , Durmaz, Ö. & Gökçay, G. (2021). Administration of Attenuated Live Vaccines Before and After Liver Transplantation in Childhood: Single Center Experience in Turkey . Osmangazi Tıp Dergisi , 43 (3) , 239-246 . DOI: 10.20515/otd.809021
MLA Keskindemirci, G. , Önal, Z. , Özbay, Y. Ş. , Özek, E. , Hançerli Törün, S. , Durmaz, Ö. , Gökçay, G. "Administration of Attenuated Live Vaccines Before and After Liver Transplantation in Childhood: Single Center Experience in Turkey" . Osmangazi Tıp Dergisi 43 (2021 ): 239-246 <https://dergipark.org.tr/tr/pub/otd/issue/61364/809021>
Chicago Keskindemirci, G. , Önal, Z. , Özbay, Y. Ş. , Özek, E. , Hançerli Törün, S. , Durmaz, Ö. , Gökçay, G. "Administration of Attenuated Live Vaccines Before and After Liver Transplantation in Childhood: Single Center Experience in Turkey". Osmangazi Tıp Dergisi 43 (2021 ): 239-246
RIS TY - JOUR T1 - Administration of Attenuated Live Vaccines Before and After Liver Transplantation in Childhood: Single Center Experience in Turkey AU - Gonca Keskindemirci , Zerrin Önal , Yeşfa Şebnem Özbay , Esra Özek , Selda Hançerli Törün , Özlem Durmaz , Gülbin Gökçay Y1 - 2021 PY - 2021 N1 - doi: 10.20515/otd.809021 DO - 10.20515/otd.809021 T2 - Osmangazi Tıp Dergisi JF - Journal JO - JOR SP - 239 EP - 246 VL - 43 IS - 3 SN - 1305-4953-2587-1579 M3 - doi: 10.20515/otd.809021 UR - https://doi.org/10.20515/otd.809021 Y2 - 2020 ER -
EndNote %0 Osmangazi Tıp Dergisi Administration of Attenuated Live Vaccines Before and After Liver Transplantation in Childhood: Single Center Experience in Turkey %A Gonca Keskindemirci , Zerrin Önal , Yeşfa Şebnem Özbay , Esra Özek , Selda Hançerli Törün , Özlem Durmaz , Gülbin Gökçay %T Administration of Attenuated Live Vaccines Before and After Liver Transplantation in Childhood: Single Center Experience in Turkey %D 2021 %J Osmangazi Tıp Dergisi %P 1305-4953-2587-1579 %V 43 %N 3 %R doi: 10.20515/otd.809021 %U 10.20515/otd.809021
ISNAD Keskindemirci, Gonca , Önal, Zerrin , Özbay, Yeşfa Şebnem , Özek, Esra , Hançerli Törün, Selda , Durmaz, Özlem , Gökçay, Gülbin . "Administration of Attenuated Live Vaccines Before and After Liver Transplantation in Childhood: Single Center Experience in Turkey". Osmangazi Tıp Dergisi 43 / 3 (Mayıs 2021): 239-246 . https://doi.org/10.20515/otd.809021
AMA Keskindemirci G. , Önal Z. , Özbay Y. Ş. , Özek E. , Hançerli Törün S. , Durmaz Ö. , Gökçay G. Administration of Attenuated Live Vaccines Before and After Liver Transplantation in Childhood: Single Center Experience in Turkey. Osmangazi Tıp Dergisi. 2021; 43(3): 239-246.
Vancouver Keskindemirci G. , Önal Z. , Özbay Y. Ş. , Özek E. , Hançerli Törün S. , Durmaz Ö. , Gökçay G. Administration of Attenuated Live Vaccines Before and After Liver Transplantation in Childhood: Single Center Experience in Turkey. Osmangazi Tıp Dergisi. 2021; 43(3): 239-246.
IEEE G. Keskindemirci , Z. Önal , Y. Ş. Özbay , E. Özek , S. Hançerli Törün , Ö. Durmaz ve G. Gökçay , "Administration of Attenuated Live Vaccines Before and After Liver Transplantation in Childhood: Single Center Experience in Turkey", Osmangazi Tıp Dergisi, c. 43, sayı. 3, ss. 239-246, May. 2021, doi:10.20515/otd.809021

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