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COVID-19 Vaccines Can Initiate or Exacerbate A Rheumatic Disease; A Report of 4 Cases

Yıl 2022, Cilt: 44 Sayı: 4, 576 - 579, 19.07.2022
https://doi.org/10.20515/otd.1035188

Öz

Vaccination has been playing an anchor role in controlling the COVID-19 pandemic. Notably, mRNA-based novel vaccines against SARS-CoV2 have increased some speculations among rheumatologists and patients with autoimmune disorders, whether they may reactivate the presenting disease or unveil a new autoimmune disease because of the absence of randomized controlled tirals pioneering their effects in this specific population. Despite these theoretical concerns on immune hyperactivation, vaccination has been performed widespreadly because benefits outweigh mortality risks in this population. Recent observational studies showed that disease flares are seen in rheumatic diseases after vaccination. On the other hand, case reports and case series have been increasingly published that autoimmune disorders may be emerged following vaccination. Herein, we report 4 cases including flares and an occurence of rheumatic disease after mRNA vaccination.

Kaynakça

  • 1-Terracina KA, Tan FK. A flare of rheumatoid arthritis after COVID-19 vaccination. Lancet Rheumatol 2021; 7: e469-70.
  • 2-Magliulo D, Narayan S, Ue F, et al. Adult-onset Still's disease after mRNA COVID-19 vaccine. Lancet Rheumatol 2021 Jul 22. doi: 10.1016/S2665-9913(21)00219-8.
  • 3-Obeid M, Fenwick C, Pantaleo G. Reactivation of IgA vasculitis after COVID-19 vaccination. Lancet Rheumatol 2021; 9: e617.
  • 4-AlGhoozi DA, AlKhayyat HM. A child with Henoch-Schonlein purpura secondary to a COVID-19 infection. BMJ Case Rep 2021; 14: e239910.
  • 5-Kreuter A, Licciardi-Fernandez MJ, Burmann SN, et al. Induction, and exacerbation of subacute cutaneous lupus erythematosus following messenger-RNA or adenoviral-vector based SARS-CoV-2 vaccination. Clin Exp Dermatol 2021 Jul 22. doi: 10.1111/ced.14858. Epub ahead of print. PMID: 34291477.
  • 6-Shakoor MT, Birkenbach MP, Lynch M. ANCA-Associated Vasculitis Following Pfizer-BioNTech COVID-19 Vaccine. Am J Kidney Dis 2021 Jul 17:S0272-6386(21)00742-3. 7-Connolly CM, Ruddy JA, Boyarsky BJ, et al. Disease Flare and Reactogenicity in Patients with Rheumatic and Musculoskeletal Diseases Following Two-Dose SARS-CoV-2 Messenger RNA Vaccination. Arthritis Rheumatol 2021 Aug 4. doi: 10.1002/art.41924. Epub ahead of print. PMID: 34346185.
  • 8-Sattui SE, Liew JW, Kennedy K, et al. Early experience of COVID-19 vaccination in adults with systemic rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey. RMD Open 2021; 7: e001814.
  • 9-Arts RJW, Moorlag SJCFM, Novakovic B, et al. BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. Cell Host Microbe 2018; 23: 89-100.
  • 10-Teijaro JR, Farber DL. COVID-19 vaccines: modes of immune activation and future challenges. Nat Rev Immunol 2021; 21: 195-97.

COVİD-19 Aşıları Romatizmal Hastalığı Tetikleyebilir veya Alevlendirebilir; 4 Vakalık Derleme

Yıl 2022, Cilt: 44 Sayı: 4, 576 - 579, 19.07.2022
https://doi.org/10.20515/otd.1035188

Öz

Aşılama, COVİD-19 pandemisinin kontrol altına alınmasında önemli bir köşe taşı rolü oynamıştır. Özellikle SARS-CoV2’ye karşı geliştirilen mRNA bazlı yeni aşılar, romatizmal hastalığı olan populasyonda yeterli randomize kontrollü çalışmaları olmaması sebebiyle, hem romatologlar hem de otoimmun hastalığı olanlarda hastalığın alevlenmesi, ya da ek bir otoimmun hastalığın ortaya çıkması hususunda endişelere yol açmıştır. Teorik olarak immun hiperaktivasyona yol açabileceği düşünülse de pandeminin bu hasta grubundaki riski göz önüne alınarak aşılama uygulamalarına devam edilmiştir. Literatürde romatizmal hastalığı olanlarda aşı sonrası aktivasyon olduğuna dair gözlemsel veriler mevcuttur. Öte yandan aşı ilişkili olduğu düşünülen yeni tanı otoimmun hastalıklar olgu bildirileri şeklinde yayınlanmaktadır. Burada romatoloji kliniğimizde mRNA aşısı sonrası ortaya çıkan ve alevlenme ile başvuran 4 hasta sunduk.

Kaynakça

  • 1-Terracina KA, Tan FK. A flare of rheumatoid arthritis after COVID-19 vaccination. Lancet Rheumatol 2021; 7: e469-70.
  • 2-Magliulo D, Narayan S, Ue F, et al. Adult-onset Still's disease after mRNA COVID-19 vaccine. Lancet Rheumatol 2021 Jul 22. doi: 10.1016/S2665-9913(21)00219-8.
  • 3-Obeid M, Fenwick C, Pantaleo G. Reactivation of IgA vasculitis after COVID-19 vaccination. Lancet Rheumatol 2021; 9: e617.
  • 4-AlGhoozi DA, AlKhayyat HM. A child with Henoch-Schonlein purpura secondary to a COVID-19 infection. BMJ Case Rep 2021; 14: e239910.
  • 5-Kreuter A, Licciardi-Fernandez MJ, Burmann SN, et al. Induction, and exacerbation of subacute cutaneous lupus erythematosus following messenger-RNA or adenoviral-vector based SARS-CoV-2 vaccination. Clin Exp Dermatol 2021 Jul 22. doi: 10.1111/ced.14858. Epub ahead of print. PMID: 34291477.
  • 6-Shakoor MT, Birkenbach MP, Lynch M. ANCA-Associated Vasculitis Following Pfizer-BioNTech COVID-19 Vaccine. Am J Kidney Dis 2021 Jul 17:S0272-6386(21)00742-3. 7-Connolly CM, Ruddy JA, Boyarsky BJ, et al. Disease Flare and Reactogenicity in Patients with Rheumatic and Musculoskeletal Diseases Following Two-Dose SARS-CoV-2 Messenger RNA Vaccination. Arthritis Rheumatol 2021 Aug 4. doi: 10.1002/art.41924. Epub ahead of print. PMID: 34346185.
  • 8-Sattui SE, Liew JW, Kennedy K, et al. Early experience of COVID-19 vaccination in adults with systemic rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey. RMD Open 2021; 7: e001814.
  • 9-Arts RJW, Moorlag SJCFM, Novakovic B, et al. BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. Cell Host Microbe 2018; 23: 89-100.
  • 10-Teijaro JR, Farber DL. COVID-19 vaccines: modes of immune activation and future challenges. Nat Rev Immunol 2021; 21: 195-97.
Toplam 9 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm OLGU SUNUMLARI / CASE REPORTS
Yazarlar

Reşit Yıldırım 0000-0003-4040-0212

Döndü Üsküdar Cansu 0000-0001-6543-3905

Mustafa Dinler 0000-0002-8133-8278

Cengiz Korkmaz 0000-0003-2679-0699

Yayımlanma Tarihi 19 Temmuz 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 44 Sayı: 4

Kaynak Göster

Vancouver Yıldırım R, Üsküdar Cansu D, Dinler M, Korkmaz C. COVID-19 Vaccines Can Initiate or Exacerbate A Rheumatic Disease; A Report of 4 Cases. Osmangazi Tıp Dergisi. 2022;44(4):576-9.


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