To investigate the role of HPV(Human papillomaVirus) positivity alone in defining preinvasive/invasive disease in patients with negative cervical cytology for malignancy and positive HPVDNA screening. Patients aged 30-65 years, who were screened with primary HPV test and reflex cytology by the National Cancer Early Diagnosis, Screening and Education Center (KETEM), and who underwent colposcopic evaluation between July 2021 and March 2022, were retrospectively screened. 234 patients with negative cervical cytology and positive HPV were included in the study. The patients were divided into 4 groups according to HPV results; HPV 16 and/or 18, HPV 16/18 together with other high-risk HPV, only other high-risk HPV, low-risk HPV. Groups were compared in terms of demographic data and colposcopic results. The median age was 44(38-52). While 82(35%) of the patients were postmenopausal, 152(65%) were premenopausal. There was no difference between the groups in terms of age, body mass index, gravida, parity, menopausal status, smoking, the rate of abnormal findings in colposcopic examination, and the number of biopsies performed. The frequencies of HPV types were HPV16 (29.6%), HPV31 (17.5%), HPV52 (9.8%), HPV51 (9.4%) and HPV18 (8.1%). According to colposcopic biopsies, the rate of precancerous lesion in HPV 16 and/or 18 positivity was higher than other groups(p=0.007). According to endocervical curettage, invasive cancer was detected in two patients. High-risk oncogenic HPV subtypes (HPV 16-18) should be referred to colposcopy. With the spread of vaccination programs, other high-risk subtypes such as HPV type 31 may gain clinical importance in the upcoming years.
|Konular||Sağlık Kurumları Yönetimi|
|Bölüm||ORİJİNAL MAKALELER / ORIGINAL ARTICLES|
|Yayımlanma Tarihi||15 Mart 2023|
|Yayımlandığı Sayı||Yıl 2023 Cilt: 45 Sayı: 2|