Farklı Migren Alt Tiplerinde Willis Poligonu Varyasyonları ve Beyaz Cevher Lezyonları Arasındaki İlişki

Yıl 2024, Cilt: 46 Sayı: 4, 551 - 559, 16.07.2024

Asli Yaman Kula Serdar Balsak

https://doi.org/10.20515/otd.1478774

Öz

Migrende Willis Poligonu varyasyonlarının ve beyaz cevher lezyonlarının sık gözlendiği bilinmektedir. Bu retrospektif çalışma aurasız migren (n=38) ve auralı migren (n=40) hastalarında Willis Poligonu varyasyonları ile beyaz cevher hiperintensiteleri arasındaki ilişkiyi araştırmayı amaçlamıştır. Hastaların demografik, klinik ve radyolojik bulguları (Willis Poligonu varyasyonları ve beyaz cevher hiperintensite yükleri) kaydedildi ve değişkenler arasındaki ilişki her iki grupta değerlendirildi. Herhangi bir Willis Poligon varyasyonu varlığı, Willis Poligonu’nun anterior ya da vertebrobaziler kısmında varyasyon olması veya fetal PCA varlığı aurasız migren ve auralı migren grupları arasında anlamlı fark göstermedi (p > 0.05). Willis Poligonu’nun posterior kısmında varyasyon varlığı auralı migren grubunda aurasız migren grubuna göre anlamlı derecede yüksek bulundu (p=0,034). Auralı migren grubunda, herhangi bir Willis Poligon varyasyonuna sahip hastaların %72'sinde görsel aura mevcuttu ve bu varyasyonların tümü Willis Poligonu’nun posterior kısım varyasyonlarıydı. Aurasız ve auralı migren gruplarında beyaz cevher lezyon yükü karşılaştırıldığında, gruplar arasında anlamlı farklılık görülmedi (p > 0,05). Aurasız migren grubunda, Willis Poligonu varyasyonuna sahip olan hastalar arasında beyaz cevher lezyonu olmayan hastaların oranı anlamlı olarak daha yüksekti (p = 0,030). Auralı migren grubunda, Willis Poligon varyasyonları ile beyaz cevher lezyon yükü arasında anlamlı bir fark gözlenmedi (p > 0,05). Çalışma sonuçlarımıza göre auralı migrende Willis Poligonu’nun posterior kısım varyasyonları sık görülmüştür ve bu varyasyon görsel aura ile ilişkili, beyaz cevher lezyon yükü ile ilişkisiz bulunmuştur.

Anahtar Kelimeler

Auralı migren, Aurasız migren, Willis Poligonu

The Relationship Between the Circle of Willis Variations and White Matter Hyperintensities in Different Migraine Subtypes

Öz

It is known that the Circle of Willis (CoW) variations and white matter hyperintensities (WMHs) are common in migraine. This retrospective study aims to investigate the relationship between the CoW variations and WMHs in migraine without aura (MWoA) (n=38) and migraine with aura (MWA) (n=40) patients. Demographic, clinical and radiological findings (the CoW variations and WMH burden) of the patients were recorded, and the relationship between the variables was evaluated in both groups. The overall incomplete COW, incomplete anterior or vertebrobasilar portion of the CoW, or the presence of fetal PCA showed no significant difference between the MWoA and MWA groups (p > 0.05). An incomplete posterior portion of the CoW was significantly higher in the MWA group than in the MWoA group (p = 0.034). In the MWA group, the visual aura was present in 72% of patients with the overall incomplete CoW; all of these were posterior portion variations of the CoW. When the WMH burden was compared, no significant difference was seen between the MWoA and MWA groups (p > 0.05). Among patients with the CoW variations in the MWoA group, the rate of patients without WMHs was significantly higher (p = 0.030). No significant difference was observed between the variations and WMH burden in the MWA group (p > 0.05). According to our study results, variations in the posterior portion of the CoW are common in MWA, and while this variation is associated with visual aura, it was found to be unrelated to WMH burden.

Anahtar Kelimeler

Migraine with aura, Migraine without aura, Circle of Willis

Kaynakça

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