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Stem Cell Studies of Professor Doctor Sureyya Tahsin Aygun

Yıl 2024, Cilt: 46 Sayı: 4, 656 - 665, 16.07.2024
https://doi.org/10.20515/otd.1495919

Öz

Kök hücreler insan vücudundaki özelleşmemiş hücrelerdir. Organizmanın herhangi bir hücresine farklılaşabilirler ve kendilerini yenileme yeteneğine sahiptirler. Böylece vücuttaki tüm olgun hücrelerin oluşumuna katkıda bulunurlar ve her hücre, doku ve organın temelini oluştururlar. Bir kök hücre hem kendini yenilemeyi hem de farklılaşmayı sağlayabilir.
Süreyya Tahsin Aygün, doktorasını 1926 yılında Berlin Veteriner Fakültesi'nden aldı. Hücre kültürü üzerine yoğunlaştı ve kalp kök hücreleri üzerine çalışmalar yaptı. Kalp kök hücrelerinin rejeneratif ve proliferatif kapasitesini gözlemledi. Aygün, genç, olgunlaşmamış, homojen insan hücrelerinin beklenmedik bir tıbbi etkiye sahip olduğu sonucuna vardı çünkü hayvan hücreleri hayvan organizması için, insan hücreleri ise insan organizması için uygundu. Aygün'ün insan hücre kültürleri ile tedavisi kalp, böbrek, karaciğer ve dolaşım hastalıkları, felç, tümörler, şizofreni ve multipl skleroz gibi birçok hastalık için kullanılabilir. Patofizyolojik olarak yaşlanan hücreler gerileyip yerlerini genç, canlı insan kültür hücrelerine bıraktıkça, fizyolojik yaşın ve yaşam süresinin uzatılması ve gözle görülür bir gençleşme bile mümkün hale gelmiştir.
Süreyya Tahsin Aygün, kök hücreler üzerinde çalışan ilk Türk bilim insanıdır. Süreyya Tahsin Aygün'ün Almanya ve Türkiye'de yaptığı çalışmalar, kök hücre ve rejeneratif tıbba yaptığı katkıları ortaya koymaktadır. Aygün'ün diğer çalışmalarına bakıldığında veteriner hekimlik ile tıp arasındaki ortak araştırmaların önemi daha iyi anlaşılıyor. Ord. prof. Aygün'ün “Die Human-Zellkultur-Therapie, Neue erfolgreiche Möglichkeiten zur Therapie des Mongolismus und anderer Krankheiten” adlı eseri ve diğer eserleri günümüz tıbbındaki gelişmelere katkıları açısından yeniden yayınlanmalıdır.

Teşekkür

We would like to thank Mrs Aylin Hermann who obtained this book from Germany and sent it to us.

Kaynakça

  • 1. Charitos IA, Ballini A, Cantore S, Boccellino M, Di Domenico M, Borsani E, et al. Stem Cells: A Historical Review about Biological, Religious, and Ethical Issues. Mascitti M, editor. Stem Cells International. 2021 Apr 29;2021:1–11.
  • 2. Zakrzewski W, Dobrzyński M, Szymonowicz M, Rybak Z. Stem cells: past, present, and future. Stem Cell Res Ther. 2019 Dec;10(1):68.
  • 3. Chia WK, Cheah FC, Abdul Aziz NH, Kampan NC, Shuib S, Khong TY, et al. A Review of Placenta and Umbilical Cord-Derived Stem Cells and the Immunomodulatory Basis of Their Therapeutic Potential in Bronchopulmonary Dysplasia. Front Pediatr. 2021 Mar 9;9:615508.
  • 4. Ebrahimi A, Ahmadi H, Pourfraidon Ghasrodashti Z, Tanide N, Shahriarirad R, Erfani A, et al. Therapeutic effects of stem cells in different body systems, a novel method that is yet to gain trust: A comprehensive review. Bosn J of Basic Med Sci [Internet]. 2021 Jul 13 [cited 2024 Jun 4]; Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/5508
  • 5. Brunt KR, Weisel RD, Li RK. Stem cells and regenerative medicine — future perspectives. Can J Physiol Pharmacol. 2012 Mar;90(3):327–35.
  • 6. Aru B, Gürel G, Yanikkaya Demirel G. Mesenchymal Stem Cells: History, Characteristics and an Overview of Their Therapeutic Administration. TJI. 2022 Aug 16;10(2):56–68.
  • 7. Hoang DM, Pham PT, Bach TQ, Ngo ATL, Nguyen QT, Phan TTK, et al. Stem cell-based therapy for human diseases. Sig Transduct Target Ther. 2022 Aug 6;7(1):272.
  • 8. Çınar EN, Vatanoğlu-Lutz E. Dünyada Kök Hücre Üzerine Çalışan İlk Bilim İnsanı. Nobel Med. 2018;14(13):55–7.
  • 9. Ferruh D. Ord. Prof. Dr. Sureyya Tahsin Aygyün’ün Hayatı ve Bilimsel Çalışmaları. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 1982;50(1):1–1.
  • 10. Süreyya Tahsin Aygün. Die Human Zelkultur Therapie. Germany; 1976.
  • 11. Avci M. Kök Hücre; Tanımı ve Genel Özellikleri, Kullanım Alanları, Tarihi, Yüzey Belirteçleri. Arşiv Kaynak Tarama Dergisi. 2022 Jun 30;31(2):87–93.
  • 12. Durdu S, Deniz GC, Dogan A, Zaim C, Karadag A, Dastouri MR, et al. Stem cell mediated cardiovascular repair. Can J Physiol Pharmacol. 2012 Mar;90(3):337–51.
  • 13. Cassino TR, Drowley L, Okada M, Beckman SA, Keller B, Tobita K, et al. Mechanical Loading of Stem Cells for Improvement of Transplantation Outcome in a Model of Acute Myocardial Infarction: The Role of Loading History. Tissue Engineering Part A. 2012 Jun;18(11–12):1101–8.
  • 14. Shum-Tim D, Ridwan K, Alrefai M, Connell J, Paul A, Murali D. Cardiac tissue engineering and regeneration using cell-based therapy. SCCAA. 2015 May;81.
  • 15. Fisher SA, Zhang H, Doree C, Mathur A, Martin-Rendon E. Stem cell treatment for acute myocardial infarction. Cochrane Heart Group, editor. Cochrane Database of Systematic Reviews [Internet]. 2015 Sep 30 [cited 2024 Jun 4];2015(9). Available from: http://doi.wiley.com/10.1002/14651858.CD006536.pub4
  • 16. O’Donoghue K, Fisk NM. Fetal stem cells. Best Practice & Research Clinical Obstetrics & Gynaecology. 2004 Dec;18(6):853–75.
  • 17. Fauza D. Amniotic fluid and placental stem cells. Best Practice & Research Clinical Obstetrics & Gynaecology. 2004 Dec;18(6):877–91.
  • 18. Gurer F, Ozden H, Muslumanoglu H, Baycu C, Cilingir O, Hassa H. Therapeutic Use of Cloning: Osmangazi Turk Identical Embryonic Stem Cells and Embryonic Stem Cell Transfer to Diabetic Mice. JOURNAL OF HEALTH SCIENCE. 2009;55(4):503–15.

Stem Cell Studies of Professor Doctor Sureyya Tahsin Aygun

Yıl 2024, Cilt: 46 Sayı: 4, 656 - 665, 16.07.2024
https://doi.org/10.20515/otd.1495919

Öz

Stem cells are unspecialized cells in the human body. They can differentiate into any cell of the organism and have the ability to renew themselves. Thus, they contribute to the formation of all mature cells in the body and form the basis of every cell, tissue and organ. A stem cell can ensure both self-renewal and differentiation.
Süreyya Tahsin Aygün received his Ph.D. from the Berlin School of Veterinary Medicine in 1926. He focused on cell culture and conducted studies on cardiac stem cells. He observed the regenerative and proliferative capacity of cardiac stem cells. Aygün concluded that young, immature, homogeneous human cells have an unexpected medical effect because animal cells are suitable for animal organism and human cells are suitable for human organism. Aygün's treatment with human cell cultures can be used for many diseases such as heart, kidney, liver and circulatory diseases, stroke, tumors, schizophrenia and multiple sclerosis. Even prolongation of physiological age and life expectancy combined with visible rejuvenation has come into the realm of possibility as pathophysiologically aging cells regress and are replaced by young, viable human cultured cells.
Süreyya Tahsin Aygün is the first Turkish scientist to work on stem cells. Süreyya Tahsin Aygün's studies in Germany and Turkey demonstrate his contribution to stem cell and regenerative medicine. Looking at Aygün's other studies, one better understands the importance of joint research between veterinary medicine and medicine. Ord. prof. Aygün's work "Die Human-Zellkultur-Therapie, Neue erfolgreiche Möglichkeiten zur Therapie des Mongolismus und anderer Krankheiten" and other works should be reissued in view of their contribution to today's medical developments.

Kaynakça

  • 1. Charitos IA, Ballini A, Cantore S, Boccellino M, Di Domenico M, Borsani E, et al. Stem Cells: A Historical Review about Biological, Religious, and Ethical Issues. Mascitti M, editor. Stem Cells International. 2021 Apr 29;2021:1–11.
  • 2. Zakrzewski W, Dobrzyński M, Szymonowicz M, Rybak Z. Stem cells: past, present, and future. Stem Cell Res Ther. 2019 Dec;10(1):68.
  • 3. Chia WK, Cheah FC, Abdul Aziz NH, Kampan NC, Shuib S, Khong TY, et al. A Review of Placenta and Umbilical Cord-Derived Stem Cells and the Immunomodulatory Basis of Their Therapeutic Potential in Bronchopulmonary Dysplasia. Front Pediatr. 2021 Mar 9;9:615508.
  • 4. Ebrahimi A, Ahmadi H, Pourfraidon Ghasrodashti Z, Tanide N, Shahriarirad R, Erfani A, et al. Therapeutic effects of stem cells in different body systems, a novel method that is yet to gain trust: A comprehensive review. Bosn J of Basic Med Sci [Internet]. 2021 Jul 13 [cited 2024 Jun 4]; Available from: https://www.bjbms.org/ojs/index.php/bjbms/article/view/5508
  • 5. Brunt KR, Weisel RD, Li RK. Stem cells and regenerative medicine — future perspectives. Can J Physiol Pharmacol. 2012 Mar;90(3):327–35.
  • 6. Aru B, Gürel G, Yanikkaya Demirel G. Mesenchymal Stem Cells: History, Characteristics and an Overview of Their Therapeutic Administration. TJI. 2022 Aug 16;10(2):56–68.
  • 7. Hoang DM, Pham PT, Bach TQ, Ngo ATL, Nguyen QT, Phan TTK, et al. Stem cell-based therapy for human diseases. Sig Transduct Target Ther. 2022 Aug 6;7(1):272.
  • 8. Çınar EN, Vatanoğlu-Lutz E. Dünyada Kök Hücre Üzerine Çalışan İlk Bilim İnsanı. Nobel Med. 2018;14(13):55–7.
  • 9. Ferruh D. Ord. Prof. Dr. Sureyya Tahsin Aygyün’ün Hayatı ve Bilimsel Çalışmaları. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 1982;50(1):1–1.
  • 10. Süreyya Tahsin Aygün. Die Human Zelkultur Therapie. Germany; 1976.
  • 11. Avci M. Kök Hücre; Tanımı ve Genel Özellikleri, Kullanım Alanları, Tarihi, Yüzey Belirteçleri. Arşiv Kaynak Tarama Dergisi. 2022 Jun 30;31(2):87–93.
  • 12. Durdu S, Deniz GC, Dogan A, Zaim C, Karadag A, Dastouri MR, et al. Stem cell mediated cardiovascular repair. Can J Physiol Pharmacol. 2012 Mar;90(3):337–51.
  • 13. Cassino TR, Drowley L, Okada M, Beckman SA, Keller B, Tobita K, et al. Mechanical Loading of Stem Cells for Improvement of Transplantation Outcome in a Model of Acute Myocardial Infarction: The Role of Loading History. Tissue Engineering Part A. 2012 Jun;18(11–12):1101–8.
  • 14. Shum-Tim D, Ridwan K, Alrefai M, Connell J, Paul A, Murali D. Cardiac tissue engineering and regeneration using cell-based therapy. SCCAA. 2015 May;81.
  • 15. Fisher SA, Zhang H, Doree C, Mathur A, Martin-Rendon E. Stem cell treatment for acute myocardial infarction. Cochrane Heart Group, editor. Cochrane Database of Systematic Reviews [Internet]. 2015 Sep 30 [cited 2024 Jun 4];2015(9). Available from: http://doi.wiley.com/10.1002/14651858.CD006536.pub4
  • 16. O’Donoghue K, Fisk NM. Fetal stem cells. Best Practice & Research Clinical Obstetrics & Gynaecology. 2004 Dec;18(6):853–75.
  • 17. Fauza D. Amniotic fluid and placental stem cells. Best Practice & Research Clinical Obstetrics & Gynaecology. 2004 Dec;18(6):877–91.
  • 18. Gurer F, Ozden H, Muslumanoglu H, Baycu C, Cilingir O, Hassa H. Therapeutic Use of Cloning: Osmangazi Turk Identical Embryonic Stem Cells and Embryonic Stem Cell Transfer to Diabetic Mice. JOURNAL OF HEALTH SCIENCE. 2009;55(4):503–15.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri (Diğer)
Bölüm DERLEMELER / REVIEWS
Yazarlar

Hakan Ay 0000-0003-4638-0750

Abdullah Ortadeveci 0000-0001-6575-5699

Burak Küçük 0000-0002-0162-4742

Hilmi Özden 0000-0003-2466-2757

Yayımlanma Tarihi 16 Temmuz 2024
Gönderilme Tarihi 4 Haziran 2024
Kabul Tarihi 4 Temmuz 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 46 Sayı: 4

Kaynak Göster

Vancouver Ay H, Ortadeveci A, Küçük B, Özden H. Stem Cell Studies of Professor Doctor Sureyya Tahsin Aygun. Osmangazi Tıp Dergisi. 2024;46(4):656-65.


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