Erken Evre Mikozis Fungoides Hastalarında Psikolojik Belirtiler ve Yaşam Kalitesinin Değerlendirilmesi: Bir Vaka-Kontrol Çalışması

Yıl 2025, Cilt: 47 Sayı: 1, 95 - 101, 17.01.2025

Esra Ağaoğlu , Hanife Merve Akça , Niyazi Kürşat Çayır , Hilal Kaya Erdogan , Ersoy Acer

https://doi.org/10.20515/otd.1578873

Öz

Mikozis fungoides (MF) en sık görülen kutanöz T hücreli lenfoma türüdür. Bu çalışma erken evre MF hastalarında psikolojik belirtiler ve sağlıkla ilişkili yaşam kalitesini ölçmek ve sonuçları kontrollerle karşılaştırmak amacıyla tasarlanmıştır. Çalışmaya erken evre MF tanılı 40 hasta ve yaş ve cinsiyete uygun 40 sağlıklı kontrol dahil edildi. Tüm katılımcıların sosyodemografik özellikleri kaydedildi ve depresyon, anksiyete ve stres düzeylerini ölçmek için Depresyon, Anksiyete ve Stres Ölçeği-21 (DASÖ-21) uygulandı. Ayrıca, MF hastalarında yaşam kalitesini değerlendirmek için Skindex-29 uygulandı. MF'li hasta ve kontrol grubu arasında DASS-21 alt ölçek puanları ve toplam puanlar açısından anlamlı bir fark saptanmadı. Skindex-29'un semptom ve duygu alt ölçek puanları kadın MF hastalarında istatistiksel olarak daha yüksek bulundu. Skindex-29'a göre ileri yaş MF hastalarının daha kötü semptomları ve işlevsel bozuklukları bulunmaktaydı. DASS-21 ölçeği toplam puanları MF hastalarında tüm Skindex-29 alt ölçek puanlarıyla pozitif korelasyon gösterdi. Sonuç olarak erken evre MF'te yaşam kalitesi ileri yaş ve kadın hastalarda olumsuz olarak etkilenebilmektedir. Depresyon, anksiyete ve stres düzeyleri yüksek hastalarda sağlıkla ilişkili yaşam kalitesinin daha fazla etkilendiği görüldü. MF hastalarının psikolojik sağlıklarının iyileştirilmesiyle yaşam kaliteleri artırılabilir.

Anahtar Kelimeler

Mikozis fungoides, depresyon, anksiyete, stres, yaşam kalitesi

Etik Beyan

Çalışmamızın yürütülebilmesi için Eskişehir Osmangazi Üniversitesi Girişimsel Olmayan Klinik Araştırmalar Etik Kurulundan onay alınmıştır.

Evaluation of Psychological Symptoms and Quality of Life in Patients with Early-Stage Mycosis Fungoides: A Case-Control Study

Öz

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma. This study was designed to measure psychological symptoms and health-related quality of life in patients with early-stage MF and compare the results with controls. Forty patients with early-stage MF and 40 age- and gender-matched healthy controls were included in the study. The sociodemographic characteristics of all participants were recorded and Depression, Anxiety and Stress Scale-21 (DASS-21) was administered to measure depression, anxiety and stress levels. Additionally, Skindex-29 was applied to assess the quality of life in MF patients. No significant difference was detected between patient and control groups of MF regarding DASS-21 subscales scores and the total scores. Both symptom and emotion subscale scores of Skindex-29 were found to be statistically higher in female MF patients. Older MF patients had worse symptoms and functional impairment according to Skindex-29. The DASS-21 total scores were positively correlated with all Skindex-29 subscale scores in MF patients. In conclusion, this study demonstrated that quality of life in early-stage MF may be negatively affected in elderly and female patients. Health-related quality of life was more affected in patients with increased levels of depression, anxiety and stress. The quality of life of MF patients can be increased by improving their psychological health.

Anahtar Kelimeler

Mycosis fungoides, depression, anxiety, stress, quality of life

Kaynakça

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