Metafizyal Şok Dalga Uygulamasının Femurun Longitudinal Büyümesi Üzerindeki Etkisi: Rat Modeli

Yıl 2025, Cilt: 47 Sayı: 2, 303 - 308, 27.02.2025

Hilal Yağar , Kadir Eren Biçer , Emin Kürşat Bulut , Levent Ediz , Mehmet Ceylan

Öz

Ekstrakorporeal şok dalga tedavisinin (ESWT) artan kan akışını indüklediği ve fizyolojik kemik büyüme sürecini uyardığı düşüncesi oluşmuştur. Ayrıca, son çalışmalar ESWT'nin büyüme plağında kondrogenezi ve tavşanlarda longitudinal kemik büyümesini arttırdığını göstermiştir. Bu çalışmanın amacı, rat modelinde distal metafizyal bölgeye ESWT uygulaması sonrası femur kemiğinin longitudinal büyümesini araştırmaktır. Bu çalışmada, fizisleri kapanmamış otuz immatür rat için üriner taş tedavisi için tasarlanmış Multimed 2001- ELMED litotriptör cihazı kullanıldı. Ratlar her grupta 10’ar denek olmak üzere 3 gruba ayrıldı. Ratların yaşı 4 ile 6 hafta arasında değişmekteydi. Birinci gruba tek doz 0.3 mJ/mm2, 1000 şok dalgası; ikinci gruba tek doz 0.7 mJ/mm2, 1000 şok dalgası; üçüncü gruba ise 3 doz (haftalık periyotlarla 1 seans) 0.3 mJ/mm2, 1000 şok dalgası ketamin anestezisi altında sağ distal femur metafizyal bölgesine uygulandı. Ratların sol femurları kontrol olarak kabul edildi. Radyolojik ölçümler NetCAD 4.0 mühendislik programı ile dijital olarak yapıldı. Metafizyal şok dalgası uygulaması erken dönemde longitudinal kemik büyümesini etkilemedi (3 grupta da p>0.05). Bu sonuçlar, femurun distal metafizine uygulanan ESWT'nin ratlarda radyolojik ölçümlere dayalı olarak erken dönemde longitudinal kemik büyümesi üzerinde etkisi olmadığını göstermektedir. Yine de bu alanda daha ileri histolojik ve radyolojik çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

Anahtar kelimeler: Metafiz, şok dalga tedavisi, longitudinal kemik büyümesi, rat modeli

The Effect Of Metaphyseal Shock Wave Application On The Longitudinal Growth Of Femur: A Rat Model

Öz

There is an idea that extracorporeal shock wave therapy (ESWT) induces increased blood flow and stimulates the physiological process of bone growth on physis. Also, recent studies have shown that ESWT promotes growth plate chondrogenesis and longitudinal bone growth in rabbits. The aim of the study was to investigate the longitudinal growth of femur bone on a rat model after ESWT application on distal metaphyseal region. The present study used the Multimed 2001- ELMED lithotripter designed for urinary stone treatment on thirty immature rats with unclosed physes. Rats were divided into 3 groups consisting of 10 rats in each group. The age of the rats was ranged from 4 to 6 weeks. To the first group, single dose 0.3 mJ/mm2, 1000 shock wave; to the second group single dose 0.7 mJ/mm2, 1000 shock wave; and to the third group 3 doses (1 session weekly period) 0.3mJ/mm2, 1000 shock wave were applied on the right distal femur metaphyseal region under ketamine anesthesia. The left femurs of the same animals were accepted as controls. Radiological measurements were made digitally with the NetCAD 4.0 engineering program. Metaphyseal shock wave application did not affect the longitudinal bone growth in the early stage (p>0.05 in all 3 groups). These results indicate that ESWT applied to the distal metaphysis of the femur had no effect on early longitudinal bone growth based on radiological measurements in rats. Still there is need to further histologic and radiologic studies in this area

Anahtar Kelimeler

Metaphysis, shock wave therapy, longitudinal bone growth, rat model.

Etik Beyan

The animals were treated in accordance with the guidelines of the Yüzüncü Yıl University animal researches local ethic committee (2018/1).

Destekleyen Kurum

None

Teşekkür

None

Kaynakça

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