Akut Pankreatit Hastalarında Nötrofil/Lenfosit ve Trombosit/Lenfosit Oranlarının Tanısal ve Prognostik Değeri

Öz

Amaç: Bu çalışmada, pankreatit hastalarının hastalık şiddetinin izlenmesinde nötrofil-lenfosit oranı (NLO) ve trombosit-lenfosit oranlarının (TLO) bir parametre olarak kullanılıp kullanılamayacağını göstermeyi amaçladık.
Materyal ve Metot: Akut pankreatit tanısı ile gastroenteroloji servisinde yatan ve takip edilen, dosyaları retrospektif olarak incelenen toplam 200 hasta çalışmaya dahil edildi. Akut pankreatitin şiddeti ve prognozu Atlanta sınıflaması ile değerlendirildi.
Bulgular: NLO ortalaması hasta grubunda 9,84±9,60, kontrol grubunda ise 2,00±0,86 idi. Hasta grubunda NLO düzeyi yüksek saptandı ve cut-off değeri 2,85 olarak bulundu (Duyarlılık: %86 ve özgüllük: %81). Hastalık şiddetine göre NLO ortalamasında anlamlı bir değişiklik bulunmamakla birlikte, gruplar arasında NLO ortalamasındaki düşüş 48 saatte anlamlı bulundu.
Sonuç: Sadece ilk 48 saatteki NLO düzeyindeki değişikliğin hastalık şiddeti ile ilişkili olabileceğini bulduk. NLO'nun kullanılabilecek, uygulanabilecek ve kolay ulaşılabilecek bir parametre olduğunu gördük. 

Anahtar Kelimeler

• Akut pankreatit
• Nötrofil/Lenfosit Oranı
• Platelet/Lenfosit Oranı
• prognostik faktörler

Diagnostic and Prognostic Value of Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratios on Acute Pancreatitis Patients

Abstract

Objective: In this study, we aim at demonstrating whether we can use neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratios (PLR) as a parameter in monitoring the disease severity of Pancreatitis Patients.
Materials and Methods: A total of 200 patients diagnosed with acute pancreatitis, hospitalized and monitored in gastroenterology service, whose files had retrospectively been studied, were included in the study. The severity and prognosis of acute pancreatitis were evaluated with the Atlanta classification.
Results: The average of NLR was 9.84±9.60 in the patient group but 2.00±0.86 in the control group. The NLR level was found higher in the patient group. The cut-off value was found as 2.85 (Sensitivity: 86% and specificity: 81%). Although no significant change was found in terms of the average of NLR concerning the disease severity, the decrease in the average of NLR among the groups was found significant in 48 hours.
Conclusion: We have found that only the change in NLR level in the first 48th-hour could be associated with the disease severity. We found NLR as a parameter that can be used, applied, and accessed easily.

Keywords

• Acute pancreatitis
• neutrophil / lymphocyte ratio
• platelet / lymphocyte ratio
• prognostic factors

Kaynakça

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