Effects of Propofol and Ketamine Anesthesia on Local Temperature Changes Determined in Different Regions by Infrared Thermographic Imaging and Reflexes in Rats

Öz

Objective: This study aimed to investigate Infrared thermography (IRT) temperature measurements in rats administered two different anesthetics in terms of anesthetics and localizations.

Materials and Methods: Twenty Wistar rats were used in the study. After sedation with xylazine hydrochloride, the rats were divided into two groups (n=10). Group 1 was anesthetized with ketamine hydrochloride and Group 2 with propofol. The disappearance of movements and reflexes during the anesthesia and their return times during the awakening period were recorded. IRT recorded local temperatures before, during, and after anesthesia, including the mouth, nose, eye, ear, and rectum regions.

Results: It was determined that the return times in sense, movement, and reflexes were significantly longer in Group 2 than in Group 1 during the awakening period (p<0.05). IRT measurements during anesthesia revealed significant differences between groups (p<0.05). Statistically significant differences were found between all regions of both groups in-group comparison (p<0.05). 

Conclusion: In rats, varying local temperatures and differences were determined during anesthesia and awakening with IRT. Both groups' data showed that the ocular region was the most suitable local IRT area. Further studies are needed to examine different pathological lesions by IRT in the diagnosis and healing processes.  

Anahtar Kelimeler

• Anesthesia
• heat
• infrared thermographic imaging
• rat
• recovery

Ratlarda Propofol ve Ketamin Anestezisinin Kızılötesi Termografik Görüntüleme ile Farklı Bölgelerde Belirlenen Lokal Sıcaklık Değişimlerine ve Reflekslere Etkileri

Öz

Amaç: Bu çalışmada iki farklı genel anestezik uygulanan ratlarda indüksiyon ve uyanma dönemlerinde hareket ve reflekslerin, ayrıca farklı vücut bölgelerinde Kızılötesi termografik görüntüleme (KTG) ile lokal sıcaklık ölçümlerinin anestezikler ve lokalizasyonlar açısından incelenmesi amaçlandı.

Materyal ve Metot: Çalışmada 20 adet Wistar rat kullanıldı. Ksilazin hidroklorür ile sedasyon uygulamasından sonra ratlar iki gruba (n=10) ayrılarak Grup 1 ketamin hidroklorür, Grup 2 ise propofol ile genel anesteziye alındı. Anestezi süresince hareket ve reflekslerin kayboluşu, uyanma döneminde ise bunların dönüş süreleri kaydedildi. KTG incelemesinde ağız, burun, göz, kulak ve rektum bölgelerinde anestezi öncesi, sırası ve sonrasında belirli sürelerde lokal sıcaklıklar kaydedildi.

Bulgular: Uyanma döneminde Grup 2’de duyu, hareket ve reflekslerde dönüş süreleri Grup 1’e göre anlamlı derecede fazla bulundu (p<0,05). KTG ölçümlerinde anestezi sırasında lokal sıcaklıklarda gruplar arasında anlamlı istatistiksel farklılıklar bulundu (p<0,05). Grup içi lokal sıcaklık karşılaştırmasında her iki grupta tüm bölgeler arasında önemli istatistiksel farklar bulundu (p<0,05).

Sonuç: Ratlarda KTG ile anestezi ve uyanma sürecinde değişen lokal sıcaklık dereceleri ve farklılıklar belirlendi. Her iki grup verilerine dayanarak en uygun lokal KTG alanının oküler bölge olduğu değerlendirildi. Gelecek çalışmalarda farklı patolojik lezyonların tanı ve iyileşme süreçlerinde KTG ile incelenmesinin faydalı olacağı düşünüldü. 

Anahtar Kelimeler

• Anestezi
• ısı
• uyanma
• kızılötesi termografik görüntüleme
• rat

Kaynakça

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