The Relationship Between Orthostatic Hypotension and Vitamin D Deficiency in Patients with Uncontrolled Type 2 Diabetes Mellitus

Abstract

Objective: Vitamin D deficiency is common in diabetic patients, and studies showed that it could lead to neuropathy. Therefore, we aimed to determine relationship between 25-hydroxyvitamin D (25(OH)D) levels and orthostatic hypotension (OH) which is a component of autonomic neuropathy in diabetic patients.

Materials and Methods: A total of 118 patients with Type 2 diabetes mellitus and aged 50-65 years were included. Patients were divided into two groups as OH present and OH not present. 25(OH)D and other variable parameters were evaluated between these two groups.

Results: A total of 118 patients, 66 female and 52 male, were included in this cross-sectional study. The mean age of the patients was 56.2±3.2 years. 25(OH)D levels were found to be significantly lower in the group with OH (p<0.026). Age and sex-adjusted regression analysis were performed to examine the relationship between 25(OH)D level and OH. It was found that 25(OH)D didn’t predict the presence of OH in the univariate and multivariate analyses (p >0.05).

Conclusion: 25(OH)D levels are significantly lower in diabetic patients with OH. Although an independent relationship between them has not been demonstrated, it can be thought that correcting Vitamin D deficiency will be beneficial in the treatment of OH. 

Keywords

• Orthostatic Hypotension
• Type 2 Diabetes Mellitus
• Vitamin D Deficiency

Kontrolsüz Tip 2 Diabetes Mellitus Tanılı Hastalarda Ortostatik Hipotansiyon ile D Vitamini Eksikliği Arasındaki İlişki

Öz

Amaç: D vitamini eksikliği diyabetik hastalarda sık görülmekte ve çalışmalarda nöropatiye yol açabileceği gösterilmiştir. Bu çalışmada diyabetik hastalarda otonom nöropatinin bir bileşeni olan ortostatik hipotansiyon (OH) ile 25-hidroksivitamin D (25(OH)D) seviyesi arasındaki ilişkiyi belirlemeyi amaçladık.

Materyal ve Metot: Çalışmaya 50-65 yaş arası diyabetik toplam 118 hasta dahil edildi. Hastalar OH varlığına göre iki gruba ayrıldı. 25(OH)D ve diğer değişken parametreler bu iki grup arasında değerlendirildi.

Bulgular: Bu kesitsel çalışmaya 66 kadın ve 52 erkek olmak üzere toplam 118 hasta dahil edildi. Hastaların yaş ortalaması 56,2±3,2 yıl idi. 25(OH)D düzeyleri OH olan grupta anlamlı olarak daha düşük bulundu (p <0,026). 25(OH)D düzeyi ile OH arasındaki ilişkiyi incelemek için yaş ve cinsiyete göre ayarlanmış regresyon analizi yapıldı. Tek değişkenli ve çok değişkenli analizlerde 25(OH)D'nin OH varlığını öngörmediği bulundu (p >0,05).

Sonuç: OH'li diyabetik hastalarda 25(OH)D düzeyleri anlamlı olarak daha düşüktür. Aralarında bağımsız bir ilişki gösterilemese de OH tedavisinde D vitamini eksikliğinin düzeltilmesinin faydalı olacağı düşünülebilir. 

Anahtar Kelimeler

• D Vitamini Eksikliği
• Ortostatik Hipotansiyon
• Tip 2 Diabetes Mellitus

Kaynakça

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