Meme Kanserinde Oksidatif Stresin Prognostik Değeri ve Önemi

Öz

Amaç: Meme kanseri hastalarında Total Antioksidan Status (TAS), Total Oksidan Status (TOS), Oksidatif Stres İndeks (OSI) düzeylerini araştırmak ve bunları sağlıklı kadınlarla karşılaştırmaktır.

Materyal ve Metot: Çalışmaya 45 meme kanseri hastası ve sağlıklı 46 kadın dahil edildi. Bu hastaların serumlarında TAS ve TOS değerleri ölçülerek OSİ değerleri hesaplandı. Veriler IBM SPSS 21.0 paket programında değerlendirildi.

Bulgular: Hasta ve sağlıklı kadınların ortalama TOS değerleri karşılaştırıldığında, kontrol grubunun TOS değeri 3,44 µmIU/L, hasta grubunun TOS değeri 11,93 µmIU/L bulundu. TAS’ın ortalama değeri kontrol grubunda 1,74 µmIU/L, hasta grubunda ise 1,63 m/mol/L olarak bulundu. OSİ, meme kanserli hastalarda ortalama 7,23 iken sağlıklı kadınlarda 1,99 olarak belirlendi. Meme kanserli kadın hastalarda, sağlıklı kadınlara göre TOS değeri yüksek, TAS değeri düşük, OSİ değeri anlamlı düzeyde yüksek bulundu (p<0,01).

Sonuç: TOS, TAS ve OSİ değerleri meme kanserli hastalar ile sağlıklı kadınların ayrımında kullanılabilecek bir belirteç olabilir.

Anahtar Kelimeler

• Meme kanseri
• oksidatif stres indeks
• prognostik faktör
• total antioksidan status
• total oksidan status

Proje Numarası

Project Number: 2017-08-06-004

Prognostic Value and Significance of Oxidative Stress in Breast Cancer

Öz

Objective: The aims of this study were to investigate Total Antioxidative Status (TAS), Total Oxidative Status (TOS), and Oxidative Stress Index (OSI) levels in breast cancer patients and compare them to levels in healthy women.

Materials and Methods: In the study, 45 breast cancer patients and 46 healthy women participated. The OSI value was calculated as the % ratio of the TAS and TOS values. The data were analyzed on IBM SPSS 21.0 package software.

Results: When the mean TOS values in patients and healthy women were compared, the control group had a TOS of 3.44 µ mIU/L and the patient group had a TOS of 11.93 µ mIU/L. TAS was found to have a mean value of 1.74 µ mIU/L in the control group and 1.63 m/mol/L in the patient group. OSI was determined to have a mean value of 7.23 in patients with breast cancer and 1.99 in healthy women. In female patients with breast cancer, TOS value was higher, TAS value was lower, and OSI value was significantly higher than healthy women (p<0.01).

Conclusion: TOS, TAS and OSI values ​​can be a marker that can be used to differentiate patients with breast cancer and healthy women. 

Anahtar Kelimeler

• Breast cancer
• TAS
• TOS
• OSI
• prognostic factor.

Destekleyen Kurum

Sakarya University Scientific Research Projects Support Fund

Proje Numarası

Project Number: 2017-08-06-004

Teşekkür

The authors would like to special thanks to general surgery and clinical microbiology laboratory sections of Sakarya University, Training and Research Hospital for their help in this research.

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